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Filaggrin gene defects are associated with eczema, wheeze, and nasal disease during infancy: Prospective study

Published:April 27, 2020DOI:https://doi.org/10.1016/j.jaci.2020.02.036
      The protein filaggrin (FLG) is present in the skin and nasal epithelium and helps maintain the skin barrier while performing other functional roles.
      • Kezic S.
      • Jakasa I.
      Filaggrin and skin barrier function.
      • Miwa M.
      • Hasan S.
      • Miwa M.
      • Okubo K.
      Filaggrin exists in human nose.
      • Palmer C.N.
      • Irvine A.D.
      • Terron-Kwiatkowski A.
      • Zhao Y.
      • Liao H.
      • Lee S.P.
      • et al.
      Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis.
      Many studies have related the presence of common, loss-of-function filaggrin (FLG) gene defects to the incidence and severity of eczema
      • Palmer C.N.
      • Irvine A.D.
      • Terron-Kwiatkowski A.
      • Zhao Y.
      • Liao H.
      • Lee S.P.
      • et al.
      Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis.
      and the severity of asthma
      • Palmer C.N.
      • Ismail T.
      • Lee S.P.
      • Terron-Kwiatkowski A.
      • Zhao Y.
      • Liao H.
      • et al.
      Filaggrin null mutations are associated with increased asthma severity in children and young adults.
      ,
      • Basu K.
      • Palmer C.N.A.
      • Lipworth B.J.
      • McLean W.H.I.
      • Terron-Kwiatkowski A.
      • Zhao Y.
      • et al.
      Filaggrin null mutations are associated with increased asthma exacerbations in children and young adults.
      during childhood.
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