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      Eosinophilic esophagitis (EoE) is associated with atopic diseases. Although there is a strong genetic basis, most EoE genetic risk factors appear to result in a modest increased risk. Martin et al (p 1690) investigated whether carrying combinations of genetic variants would increase disease risk. Because atopy is in EoE patients, the focus of the investigation was to see the effect of co-existence of risk factors for EoE and atopy. Previous research identified thymic stromal lymphopoietin (TSLP) as a genetic risk factor for EoE and a locus harboring 2 closely spaced genes (IL4/KIF3A) as an atopy risk factor. Martin et al showed the following (see Figure):
      • If either (TSLP or IL4/KIF3A) genetic risk factor was found without the other, there was only a modest EoE risk.
      • Having both genetic risk factors markedly increased EoE risk.
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