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GITR cosignal in ILC2s controls allergic lung inflammation

Published:February 07, 2018DOI:https://doi.org/10.1016/j.jaci.2018.01.028
      Group 2 innate lymphoid cells (ILC2s) produce large amounts of type 2 effector cytokines such as IL-5 and IL-13, which cause allergy.
      • Spits H.
      • Cupedo T.
      Innate lymphoid cells: emerging insights in development, lineage relationships, and function.
      • Klose C.S.N.
      • Artis D.
      Innate lymphoid cells as regulators of immunity, inflammation and tissue homeostasis.
      • Eberl G.
      • Colonna M.
      • Di Santo J.P.
      • McKenzie A.N.
      Innate lymphoid cells. Innate lymphoid cells: a new paradigm in immunology.
      • Morita H.
      • Moro K.
      • Koyasu S.
      Innate lymphoid cells in allergic and nonallergic inflammation.
      ILC2s in the lung highly express glucocorticoid-induced TNFR-related protein (GITR),
      • Moro K.
      • Yamada T.
      • Tanabe M.
      • Takeuchi T.
      • Ikawa T.
      • Kawamoto H.
      • et al.
      Innate production of T(H)2 cytokines by adipose tissue-associated c-Kit(+)Sca-1(+) lymphoid cells.
      • Kamachi F.
      • Isshiki T.
      • Harada N.
      • Akiba H.
      • Miyake S.
      ICOS promotes group 2 innate lymphoid cell activation in lungs.
      and thus we hypothesized that GITR plays an important role in ILC2s.
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      References

        • Spits H.
        • Cupedo T.
        Innate lymphoid cells: emerging insights in development, lineage relationships, and function.
        Annu Rev Immunol. 2012; 30: 647-675
        • Klose C.S.N.
        • Artis D.
        Innate lymphoid cells as regulators of immunity, inflammation and tissue homeostasis.
        Nat Immunol. 2016; 17: 765-774
        • Eberl G.
        • Colonna M.
        • Di Santo J.P.
        • McKenzie A.N.
        Innate lymphoid cells. Innate lymphoid cells: a new paradigm in immunology.
        Science. 2015; 348: aaa6566
        • Morita H.
        • Moro K.
        • Koyasu S.
        Innate lymphoid cells in allergic and nonallergic inflammation.
        J Allergy Clin Immunol. 2016; 138: 1253-1264
        • Moro K.
        • Yamada T.
        • Tanabe M.
        • Takeuchi T.
        • Ikawa T.
        • Kawamoto H.
        • et al.
        Innate production of T(H)2 cytokines by adipose tissue-associated c-Kit(+)Sca-1(+) lymphoid cells.
        Nature. 2010; 463: 540-554
        • Kamachi F.
        • Isshiki T.
        • Harada N.
        • Akiba H.
        • Miyake S.
        ICOS promotes group 2 innate lymphoid cell activation in lungs.
        Biochem Biophys Res Commun. 2015; 463: 739-745
        • Wilhelm C.
        • Hirota K.
        • Stieglitz B.
        • Van Snick J.
        • Tolaini M.
        • Lahl K.
        • et al.
        An IL-9 fate reporter demonstrates the induction of an innate IL-9 response in lung inflammation.
        Nat Immunol. 2011; 12: 1071-1077
        • Turner J.E.
        • Morrison P.J.
        • Wilhelm C.
        • Wilson M.
        • Ahlfors H.
        • Renauld J.C.
        • et al.
        IL-9-mediated survival of type 2 innate lymphoid cells promotes damage control in helminth-induced lung inflammation.
        J Exp Med. 2013; 210: 2951-2965
        • Mohapatra A.
        • Van Dyken S.J.
        • Schneider C.
        • Nussbaum J.C.
        • Liang H.E.
        • Locksley R.M.
        Group 2 innate lymphoid cells utilize the IRF4-IL-9 module to coordinate epithelial cell maintenance of lung homeostasis.
        Mucosal Immunol. 2016; 9: 275-286

      References

        • Ronchetti S.
        • Nocentini G.
        • Riccardi C.
        • Pandolfi P.P.
        Role of GITR in activation response of T lymphocytes.
        Blood. 2002; 100: 350-352
        • Murata K.
        • Nose M.
        • Ndhlovu L.C.
        • Sato T.
        • Sugamura K.
        • Ishii N.
        Constitutive OX40/OX40 ligand interaction induces autoimmune-like diseases.
        J Immunol. 2002; 169: 4628-4636
        • McKenzie G.J.
        • Emson C.L.
        • Bell S.E.
        • Anderson S.
        • Fallon P.
        • Zurawski G.
        • et al.
        Impaired development of Th2 cells in IL-13-deficient mice.
        Immunity. 1998; 9: 423-432
        • Moro K.
        • Ealey K.N.
        • Kabata H.
        • Koyasu S.
        Isolation and analysis of group 2 innate lymphoid cells in mice.
        Nat Protoc. 2015; 10: 792-806
        • Mizushima S.
        • Nagata S.
        pEF-BOS, a powerful mammalian expression vector.
        Nucleic Acids Res. 1990; 18: 5322
        • Suda T.
        • Nagata S.
        Purification and characterization of the Fas-ligand that induces apoptosis.
        J Exp Med. 1994; 179: 873-879
        • Matute-Bello G.
        • Downey G.
        • Moore B.B.
        • Groshong S.D.
        • Matthay M.A.
        • Slutsky A.S.
        • et al.
        An official American Thoracic Society Workshop report: features and measurements of experimental acute lung injury in animals.
        Am J Respir Cell Mol Biol. 2011; 44: 715-738