Advertisement

Nitric oxide induces human CLA+CD25+Foxp3+ regulatory T cells with skin-homing potential

      Ultraviolet (UV) phototherapy is widely used to treat inflammatory skin diseases. Side effects include skin burning and photo-aging as well as an increase in the risk of skin cancer. Identification of the molecular mechanisms involved in disease improvement may provide alternative treatments without side effects. Although vitamin D is known to contribute to phototherapy-induced immunoregulation, this still occurs independently of vitamin D, suggesting that alternative key mechanisms are involved.
      • Hart P.H.
      • Gorman S.
      • Finlay-Jones J.J.
      Modulation of the immune system by UV radiation: more than just the effects of vitamin D?.
      To read this article in full you will need to make a payment

      References

        • Hart P.H.
        • Gorman S.
        • Finlay-Jones J.J.
        Modulation of the immune system by UV radiation: more than just the effects of vitamin D?.
        Nat Rev Immunol. 2011; 11: 584-596
        • Mowbray M.
        • McLintock S.
        • Weerakoon R.
        • Lomatschinsky N.
        • Jones S.
        • Rossi A.G.
        • et al.
        Enzyme-independent NO stores in human skin: quantification and influence of UV radiation.
        J Invest Dermatol. 2009; 129: 834-842
        • Devenney I.
        • Norrman G.
        • Forslund T.
        • Falth-Magnusson K.
        • Sundqvist T.
        Urinary nitric oxide excretion in infants with eczema.
        Pediatr Allergy Immunol. 2010; 21: e229-e234
        • Kuchel J.M.
        • Barnetson R.S.C.
        • Halliday G.M.
        Nitric oxide appears to be a mediator of solar-simulated ultraviolet radiation-induced immunosuppression in humans.
        J Invest Dermatol. 2003; 121: 587-593
        • Mestas J.
        • Hughes C.C.
        Of mice and not men: differences between mouse and human immunology.
        J Immunol. 2004; 172: 2731-2738
        • Jayaraman P.
        • Alfarano M.G.
        • Svider P.F.
        • Parikh F.
        • Lu G.
        • Kidwai S.
        • et al.
        iNOS expression in CD4+ T cells limits Treg induction by repressing TGFβ1: combined iNOS inhibition and Treg depletion unmask endogenous antitumor immunity.
        Clin Cancer Res. 2014; 20: 6439-6451
        • Niedbala W.
        • Cai B.
        • Liu H.
        • Pitman N.
        • Chang L.
        • Liew F.Y.
        Nitric oxide induces CD4+ CD25+ Foxp3− regulatory T cells from CD4+ CD25− T cells via p53, IL-2, and OX40.
        Proc Natl Acad Sci U S A. 2007; 104: 15478-15483
        • Clark R.A.
        • Kupper T.S.
        IL-15 and dermal fibroblasts induce proliferation of natural regulatory T cells isolated from human skin.
        Blood. 2007; 109: 194-202
        • Loser K.
        • Beissert S.
        Regulatory T cells: banned cells for decades.
        J Invest Dermatol. 2012; 132: 864-871

      References

        • Loser K.
        • Beissert S.
        Regulatory T cells: banned cells for decades.
        J Invest Dermatol. 2012; 132: 864-871
        • Mowbray M.
        • McLintock S.
        • Weerakoon R.
        • Lomatschinsky N.
        • Jones S.
        • Rossi A.G.
        • et al.
        Enzyme-independent NO stores in human skin: quantification and influence of UV radiation.
        J Invest Dermatol. 2009; 129: 834-842
        • Feelisch M.
        • Rassaf T.
        • Mnaimneh S.
        • Singh N.
        • Bryan N.S.
        • Jourd'Heuil D.
        • et al.
        Concomitant S-, N-, and heme-nitros(yl)ation in biological tissues and fluids: implications for the fate of NO in vivo.
        FASEB J. 2002; 16: 1775-1785