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Omalizumab is effective in cold urticaria—results of a randomized placebo-controlled trial

Published:April 04, 2017DOI:https://doi.org/10.1016/j.jaci.2017.01.043
      Cold urticaria, a common and dangerous form of chronic inducible urticaria, is characterized by itchy wheals, angioedema, or both that typically occur within minutes at cold-exposed skin and mucosal sites.
      • Magerl M.
      • Altrichter S.
      • Borzova E.
      • Gimenez-Arnau A.
      • Grattan C.E.
      • Lawlor F.
      • et al.
      The definition, diagnostic testing, and management of chronic inducible urticarias—the EAACI/GA(2) LEN/EDF/UNEV consensus recommendations 2016 update and revision.
      Cold urticaria accounts for one-third of all cases of physical urticaria, and it is the most dangerous urticaria disease with potential loss of consciousness and death due to extensive cold contact.
      • Abajian M.
      • Mlynek A.
      • Maurer M.
      Physical urticaria.
      Up to 72% of patients with cold urticaria experience systemic reactions after extensive cold contact.
      • Abajian M.
      • Mlynek A.
      • Maurer M.
      Physical urticaria.
      The underlying cause of cold urticaria is as of yet largely unknown. However, at least in some patients, IgE has been shown to be a relevant factor.
      • Kaplan A.P.
      • Garofalo J.
      • Sigler R.
      • Hauber T.
      Idiopathic cold urticaria: in vitro demonstration of histamine release upon challenge of skin biopsies.
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