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Accelerated T-cell activation and differentiation of polar subsets characterizes early atopic dermatitis development

      Infancy is a crucial period for immune development. Cellular immune responses are immature at birth, with decreased natural killer cell activity and regulatory responses.
      • Gasparoni A.
      • Ciardelli L.
      • Avanzini A.
      • Castellazzi A.M.
      • Carini R.
      • Rondini G.
      • et al.
      Age-related changes in intracellular TH1/TH2 cytokine production, immunoproliferative T lymphocyte response and natural killer cell activity in newborns, children and adults.
      Little is known about T-cell activation and subset differentiation in patients with atopic dermatitis (AD) during disease initiation in the first years of life.
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