Plasma Cytokine/Chemokine Profiles in Non-IgE-Mediated Gastrointestinal Food Allergy

      Reports of non-IgE-mediated gastrointestinal food allergy (non-IgE-GI-FA) cases have increased in recent decades. We previously reported that the antigen-specific cytokine secretion profile of PBMCs from non-IgE-GI-FA patients is Th2-predominant. Also, massive eosinophilia was observed in approximately 70% of biopsy specimens from those non-IgE-GI-FA patients. However, it remains unclear how lymphocytes are recruited to the GI tract in those patients and to the skin in IgE-mediated food allergy (IgE-FA) patients. We examined plasma cytokine/chemokine levels in order to elucidate the Th2-predominant pathogenesis shared by non-IgE-GI-FA and IgE-FA and to identify differences in lymphocyte recruiting factors between non-IgE-mediated and IgE-mediated allergies.
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