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Enhanced CD46-induced regulatory T cells suppress allergic inflammation after Dermatophagoides pteronyssinus–specific immunotherapy

      Induction of CD4+ naturally occurring regulatory T (Treg) cells was associated with successful allergen-specific immunotherapy (SIT).
      • Akdis C.A.
      • Akdis M.
      Mechanisms of allergen-specific immunotherapy: multiple suppressor factors at work in immune tolerance to allergens.
      Adaptive regulatory T (TR1) cells, which secrete immunosuppressive cytokines, might play an important role in the pathogenesis of asthma to maintain immune tolerance.
      • Akdis C.A.
      • Akdis M.
      Mechanisms of allergen-specific immunotherapy: multiple suppressor factors at work in immune tolerance to allergens.
      • Tsai Y.G.
      • Chiou Y.L.
      • Chien J.W.
      • Wu H.P.
      • Lin C.Y.
      Induction of IL-10+ CD4+CD25+ regulatory T cells with decreased NF-kappaB expression during immunotherapy.
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        Induction of IL-10+ CD4+CD25+ regulatory T cells with decreased NF-kappaB expression during immunotherapy.
        Pediatr Allergy Immunol. 2010; 21: e166-e173
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      References

        • Tsai Y.G.
        • Chiou Y.L.
        • Chien J.W.
        • Wu H.P.
        • Lin C.Y.
        Induction of IL-10+ CD4+CD25+ regulatory T cells with decreased NF-kappaB expression during immunotherapy.
        Pediatr Allergy Immunol. 2010; 21: e166-e173
        • Tsai Y.G.
        • Niu D.M.
        • Yang K.D.
        • Hung C.H.
        • Yeh- Y.J.
        • Lee C.Y.
        • et al.
        Functional defects of CD46-induced regulatory T cells to suppress airway inflammation in mite allergic asthma.
        Lab Invest. 2012; 92: 1260-1269