Abbreviations used:AR (Allergic rhinitis), B58C (British 1958 Birth Cohort), ECRHS (European Community Respiratory Health Survey), GWAS (Genome-wide association study), NFBC1966 (Northern Finland Birth Cohort of 1966), NOD1 (Nucleotide-binding oligomerization domain containing 1), SAPALDIA (Swiss Study on Air Pollution and Lung Disease in Adults), SLC25A46 (Solute carrier family 25 member 46), SNP (Single nucleotide polymorphism), STAT6 (Signal transducer and activator of transcription 6), TLR6 (Toll-like receptor 6), TMEM232 (Transmembrane protein 232), TSLP (Thymic stromal lymphopoietin)
- Changes in asthma prevalence: two surveys 15 years apart.Arch Dis Child. 1989; 64: 1452-1456
- Respiratory symptoms and atopy in Aberdeen schoolchildren: evidence from two surveys 25 years apart.BMJ. 1992; 304: 873-875
- Discovering susceptibility genes for asthma and allergy.Nat Rev Immunol. 2008; 8: 169-182
- Major genes regulating total serum immunoglobulin E levels in families with asthma.Am J Hum Genet. 2000; 67: 1163-1173
- Asthma genetics 2006: the long and winding road to gene discovery.Genes Immun. 2006; 7: 95-100
- STAT6 as an asthma candidate gene: polymorphism-screening, association and haplotype analysis in a Caucasian sib-pair study.Hum Mol Genet. 2002; 11: 613-621
- Genome-wide scan on total serum IgE levels identifies FCER1A as novel susceptibility locus.PLoS Genet. 2008; 4: e1000166
- A large-scale, consortium-based genomewide association study of asthma.N Engl J Med. 2010; 363: 1211-1221
- A genome-wide association study to identify genetic determinants of atopy in subjects from the United Kingdom.J Allergy Clin Immunol. 2011; 127 (e1-3): 223-231
- Hay fever, hygiene, and household size.BMJ. 1989; 299: 1259-1260
- Family size, infection and atopy: the first decade of the “hygiene hypothesis.”.Thorax. 2000; 55: S2-S10
- Does a higher number of siblings protect against the development of allergy and asthma? A review.J Epidemiol Community Health. 2002; 56: 209-217
- Lifecourse influences on health among British adults: effects of region of residence in childhood and adulthood.Int J Epidemiol. 2007; 36: 522-531
- The European Community Respiratory Health Survey.Eur Respir J. 1994; 7: 954-960
- The association of family size with atopy and atopic disease.Clin Exp Allergy. 1997; 27: 240-245
- Genes for asthma? An analysis of the European Community Respiratory Health Survey.Am J Respir Crit Care Med. 1997; 156: 1773-1780
- Groups at risk in low birth weight infants and perinatal mortality.Acta Paediatr Scand. 1969; 193 (1+)
- Reduced exposure to PM10 and attenuated age-related decline in lung function.N Engl J Med. 2007; 357: 2338-2347
- Follow-up of the Swiss Cohort Study on Air Pollution and Lung Diseases in Adults (SAPALDIA 2) 1991-2003: methods and characterization of participants.Soz Praventivmed. 2005; 50: 245-263
R Development Core Team (2008). R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria. ISBN 3-900051-07-0. Available at: http://www.R-project.org. Accessed September 29, 2011.
HuGE Literature Finder. HuGE navigator. Available at: http://www.hugenavigator.net/HuGENavigator/startPagePubLit.do. Accessed September 9, 2010.
- BioMart Central Portal—unified access to biological data.Nucleic Acids Res. 2009; 37: W23-W27
- Gene-environment interaction in genome-wide association studies.Am J Epidemiol. 2009; 169: 219-226
- Gene-environment interaction for childhood asthma and exposure to farming in Central Europe.J Allergy Clin Immunol. 2011; 127: 138-144
- A common variant on chromosome 11q13 is associated with atopic dermatitis.Nat Genet. 2009; 41: 596-601
- Chromosome 11q13.5 variant associated with childhood eczema: an effect supplementary to filaggrin mutations.J Allergy Clin Immunol. 2010; 125 (e1-2): 170-174
- The eczema risk variant on chromosome 11q13 (rs7927894) in the population-based ALSPAC cohort: a novel susceptibility factor for asthma and hay fever.Hum Mol Genet. 2011; 20: 2443-2449
- The role of thymic stromal lymphopoietin in allergic inflammation and chronic obstructive pulmonary disease.Arch Immunol Ther Exp (Warsz). 2010; 58: 81-90
- International variations in associations of allergic markers and diseases in children: ISAAC Phase Two.Allergy. 2010; 65: 766-775
- Ragweed hay fever: genetic control and linkage to HL-A haplotypes.Science. 1972; 178: 1201-1203
- A genome-wide association study of global gene expression.Nat Genet. 2007; 39: 1202-1207
Genome-wide evaluation of validity and efficiency of genotype imputation [database on the Internet]. Available at: http://www.sph.umich.edu/csg/liang/imputation/. Accessed September 9, 2010.
- Pollen seasons: forecasts of the most important allergenic plants in Finland.Allergy. 1986; 41: 233-242
- TSLP polymorphisms are associated with asthma in a sex-specific fashion.Allergy. 2010; 65: 1566-1575
- Unifying candidate gene and GWAS approaches in asthma.PLoS One. 2010; 5: e13894
- Elder siblings enhance the effect of filaggrin mutations on childhood eczema: results from the 2 birth cohort studies LISAplus and GINIplus.J Allergy Clin Immunol. 2010; 125 (e5): 1254-1260
Details of the many charities, governmental bodies, and scientific funding organizations that supported the epidemiologic study, including phenotyping, DNA collection, and genotyping for the British 1958 Birth Cohort (B58C), the European Community Respiratory Health Survey (ECRHS2), the Northern Finland Birth Cohort of 1966 (NFBC1966), and the Swiss Study on Air Pollution and Lung Disease in Adults (SAPALDIA), can be found in this article’s Online Repository at www.jacionline.org. A. R. has received research support from the European Commission (through project GABRIEL, contract no. 018996 under the Integrated Program LSH-2004-1.2.5-1) and the Department of Health, United Kingdom . U. S. was supported by Medical Research Council studentship grant G0500539 .
Disclosure of potential conflict of interest: M. Wjst receives research support from the Helmholtz Center and EU Project European . T. Rochat receives research support from the Swiss National Foundation for Scientific Research . The rest of the authors have declared that they have no conflict of interest.