Association Of Ige Serum Concentration, Total Eosinophil Count With Symptom Severity In Children With House Dust Mite Allergic Rhinitis

      RATIONALE: Elevated levels of serum total immunoglobulin E (IgE), serum allergen-specific IgE, blood eosinophil count are considered to be associated with allergic rhinitis (AR), but the relationships between these allergic inflammatory markers and the clinical severity of AR remain controversial.
      METHODS: Ninety-two children aged 4 to 16 years old were selected, including 70 with HDM AR and 22 with non-AR as controls. The total nasal symptom score was calculated for each patient from a questionnaire and was analyzed for association with blood total eosinophil count(TEC), total serum IgE, and serum allergen-specific IgE.
      RESULTS: Levels of all allergic inflammatory markers in children with HDM AR were significantly different from those in non-allergic children. All of the markers were related to the severity of HDM AR in bivariate correlation analysis. On multiple linear regression analysis, TEC (p<0.05) and serum allergen-specific IgE (p=0.001) were independent predictors.
      CONCLUSIONS: These results suggest that TEC and serum allergen-specific IgE, systemic allergic inflammatory marker, are correlated with the severity of HDM AR in children. Our data suggest that TEC and specific IgE can be used as a parameter for severity of symptoms of AR in children. Further study in larger populations is needed to confirm our findings.