Advertisement

Adverse reactions during peanut oral immunotherapy home dosing

Published:November 13, 2009DOI:https://doi.org/10.1016/j.jaci.2009.09.042
      Oral immunotherapy (OIT) is increasingly being investigated as a potential treatment for peanut and other food allergies, with a recent study demonstrating evidence of clinical desensitization and immunologic changes suggesting the development of long-term tolerance.
      • Jones S.M.
      • Pons L.
      • Roberts J.L.
      • Scurlock A.M.
      • Perry T.T.
      • Kulis M.
      • et al.
      Clinical efficacy and immune regulation with peanut oral immunotherapy.
      Unlike traditional subcutaneous immunotherapy for inhalant allergens, peanut OIT is administered daily, with the vast majority of doses given at home. In our peanut OIT protocols, subjects are seen in the research unit for observed dose escalations every 2 weeks, and subsequent doses are given at home. In the open-label study of peanut OIT, home doses were generally well tolerated.
      • Hofmann A.M.
      • Scurlock A.M.
      • Jones S.M.
      • Palmer K.P.
      • Lokhnygina Y.
      • Steele P.H.
      • et al.
      Safety of a peanut oral immunotherapy protocol in children with peanut allergy.
      The incidence of allergic reactions with any home dose was 3.5%, with mild upper respiratory and skin symptoms being the most common complaints.
      To read this article in full you will need to make a payment

      Subscribe:

      Subscribe to Journal of Allergy and Clinical Immunology
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Jones S.M.
        • Pons L.
        • Roberts J.L.
        • Scurlock A.M.
        • Perry T.T.
        • Kulis M.
        • et al.
        Clinical efficacy and immune regulation with peanut oral immunotherapy.
        J Allergy Clin Immunol. 2009; 124 (e1-97): 292-300
        • Hofmann A.M.
        • Scurlock A.M.
        • Jones S.M.
        • Palmer K.P.
        • Lokhnygina Y.
        • Steele P.H.
        • et al.
        Safety of a peanut oral immunotherapy protocol in children with peanut allergy.
        J Allergy Clin Immunol. 2009; 124 (e1-6): 286-291
        • Cox L.
        • Li J.T.
        • Nelson H.
        • Lockey R.
        Allergen immunotherapy: a practice parameter second update.
        J Allergy Clin Immunol. 2007; 120: S25-S85
        • Staden U.
        • Rolinck-Werninghaus C.
        • Brewe F.
        • Wahn U.
        • Niggemann B.
        • Beyer K.
        Specific oral tolerance induction in food allergy in children: efficacy and clinical patterns of reaction.
        Allergy. 2007; 62: 1261-1269
        • Meglio P.
        • Bartone E.
        • Plantamura M.
        • Arabito E.
        • Giampietro P.G.
        A protocol for oral desensitization in children with IgE-mediated cow's milk allergy.
        Allergy. 2004; 59: 980-987
        • Skripak J.M.
        • Nash S.D.
        • Rowley H.
        • Brereton N.H.
        • Oh S.
        • Hamilton R.G.
        • et al.
        A randomized, double-blind, placebo-controlled study of milk oral immunotherapy for cow's milk allergy.
        J Allergy Clin Immunol. 2008; 122: 1154-1160