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Allergic skin diseases

Published:November 25, 2009DOI:https://doi.org/10.1016/j.jaci.2009.05.039
      The skin is one of the largest immunologic organs and is affected by both external and internal factors, as well as innate and adaptive immune responses. Many skin disorders, such as atopic dermatitis, contact dermatitis, urticaria, angioedema, psoriasis, and autoimmune blistering disorders, are immune mediated. Most of these diseases are chronic, inflammatory, and proliferative, in which both genetic and environmental factors play important roles. These immunologic mechanisms might have implications for potential targets of future therapeutic interventions.

      Key words

      Abbreviations used:

      ACD (Allergic contact dermatitis), AD (Atopic dermatitis), AMP (Antimicrobial peptide), ASST (Autologous serum skin test), BHR (Basophil histamine release), BP (Bullous pemphigoid), CAPB (Cocoamidopropyl betaine), CD (Contact dermatitis), CIU (Chronic idiopathic urticaria), CU (Chronic urticaria), DC (Dendritic cell), EH (Eczema herpeticum), FDA (US Food and Drug Administration), HBD (Human β-defensin), ICD (Irritant contact dermatitis), IDEC (Inflammatory dendritic epidermal cell), IVIG (Intravenous immunoglobulin), LC (Langerhans cell), NACDG (North American Contact Dermatitis Group), PDC (Plasmacytoid dendritic cell), PPD (Paraphenylenediamine), PV (Pemphigus vulgaris), ROAT (Repeat open application test), SCD (Systemic contact dermatitis), TLR (Toll-like receptor), T.R.U.E. TEST (Thin layer rapid use epicutaneous test), TSLP (Thymic stromal lymphopoietin)
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