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American Academy of Allergy, Asthma & Immunology Work Group Report: Exercise-induced asthma

Published:April 13, 2007DOI:https://doi.org/10.1016/j.jaci.2007.02.041
      It has long been recognized, even during biblical times, that physical exercise may induce asthma symptoms in susceptible individuals.
      • Chan-Yeung M.
      • Malo J.L.
      • Tarlo S.M.
      • Bernstein L.
      • Gautrin D.
      • Mapp C.
      • et al.
      Proceedings of the first Jack Pepys Occupational Asthma Symposium.
      Nevertheless, the term exercise-induced asthma (EIA) only became popular in the 1960s and 1970s when several reports addressed the pattern of airway response to exercise and the influence of drugs on EIA, particularly in children.
      • Jones R.S.
      • Buston M.H.
      • Wharton M.J.
      The effect of exercise on ventilatory function in the child with asthma.
      • Godfrey S.
      Exercise testing in children.
      Subsequently, reports of studies of the mechanisms causing EIA
      • Anderson S.D.
      • Daviskas E.
      The mechanism of exercise-induced asthma is….
      often asserted that EIA represents a distinct clinical category of asthma. In fact, most if not all patients with asthma develop symptoms of asthma after a suitable exercise challenge.
      • Crapo R.O.
      • Casaburi R.
      • Coates A.L.
      • Enright P.L.
      • Hankinson J.L.
      • Irvin C.G.
      • et al.
      Guidelines for methacholine and exercise challenge testing: 1999.
      Moreover, even cases of asthma in which exercise appears to be the only trigger of bronchial obstruction (pure EIA) may be manifestations of chronic inflammation of the airways.
      • Karjalainen E.M.
      • Laitinen A.
      • Sue-Chu M.
      • Altraja A.
      • Bjermer L.
      • Laitinen L.A.
      Evidence of airway inflammation and remodeling in ski athletes with and without bronchial hyperresponsiveness to methacholine.
      • Verges S.
      • Flore P.
      • Blanchi M.P.
      • Wuyam B.
      A 10-year follow-up study of pulmonary function in symptomatic elite cross-country skiers: athletes and bronchial dysfunctions.
      • Helenius I.
      • Lumme A.
      • Haahtela T.
      Asthma, airway inflammation and treatment in elite athletes.

      Key words

      Abbreviations used:

      EIA (Exercise-induced asthma), EIAna (Exercise-induced anaphylaxis), EIB (Exercise-induced bronchospasm), EILD (Exercise-induced laryngeal dysfunction), EVH (Eucapnic voluntary hyperventilation), FDEIAna (Food-dependent exercise-induced anaphylaxis), GERD (Gastroesophageal reflux disease)
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