Effects of a Novel Symbiotic, ImmuBalance, as a Food Supplement in Relieving Clinical Symptoms of Japanese Cedar Pollonosis: A Pilot Study

      RATIONALE: Japanese cedar polinosis (JCP) is a common allergic disease with morbidity of approximately 20% in the Japanese population and increasing. Our previous study showed that a novel symbiotic - a koji fungus (Aspergillus oryzae) and lactobacillus soybean fermentation product (ImmuBalance, Nichimo, Japan) - could be used as a kind of allergen-specific immunotherapy to downregulate peanut-specific response in peanut-allergic mice. In the current study, we determined the effect of ImmuBalance on prevention and treatment of allergic reactions in JCP during the pollen season.
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