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The Significance of Clonality and Affinity of Individual Allergen-Specific IgE Antibodies for the Activation of Human Basophils

      RATIONALE: In allergic individuals symptoms arise from activation of effector cells through allergen-mediated cross-linking of FcεRI-bound IgE. The allergen-specific IgE response is polyclonal, but only little is known to what extent the clonality of the IgE-response and affinity of the individual IgE molecules affect the allergic response. Here we test a panel of well characterized recombinant IgE antibodies with varying affinities toward the major house dust mite allergen Derp2 in a human basophil degranulation assay.
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