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Abstract
Rationale
The aim of this study was to establish the connection between concentration of LTC4 and histamine and occurrence of IgG against Candida albicans in serum from patients with bronchial asthma.
Methods
19 patients with bronchial asthma aged 1 to 56 were examined, in whom high concentration of IgG against Candida albicans were established, comparing to the control group (19 patients), in which concentration of IgG against Candida albicans were low. Concentration of histamine (EIA method-Immunotech, France) and LTC4 (EIA method-Amersham, G. Britain) and IgG against Candida albicans (EIA method-Allergopharma, Germany) were estimated.
Results
In examined group average concentration of IgG against Candida albicans was 32,1IU/ml, of histamine-5,376nM, and of LTC4- 41,58pg/ml. However in the control group average concentration of IgG against Candida albicans was low-0,76IU/ml, of histamine-1,8nM and LTC4-16,2pg/ml.
Conclusions
High concentration of LTC4 and histamine in serum correlate with high concentration of antibodies IgG against Candida albicans.
Article Info
Footnotes
☆Funding: Self-funded
Identification
Copyright
© 2004 Published by Elsevier Inc.
