Advertisement

Fatal posture in anaphylactic shock

      Since 1992, I have studied details of 214 deaths associated with anaphylaxis. For 196 of these deaths there is sufficient information from the descriptions of events during the reactions and autopsy findings to determine that 88 were from shock (in 38 of these, shock was combined with difficulty breathing), 96 were from asphyxia (lower airway, 49; upper airway, 22; upper and lower airways or airway unspecified, 25), 7 were from complications of disseminated intravascular coagulation, and 5 were from the effects of epinephrine overdose.
      • Pumphrey RSH.
      Lessons for the management of anaphylaxis from a study of fatal reactions.
      To read this article in full you will need to make a payment

      Subscribe:

      Subscribe to Journal of Allergy and Clinical Immunology
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Pumphrey RSH.
        Lessons for the management of anaphylaxis from a study of fatal reactions.
        Clin Exp Allergy. 2000; 30: 1144-1150
        • Boulain T
        • Achard JM
        • Teboul JL
        • Richard C
        • Perrotin D
        • Ginies G.
        Changes in BP induced by passive leg raising predict response to fluid loading in critically ill patients.
        Chest. 2002; 121: 1245-1252
        • Ceyhan C
        • Ercan E
        • Tekten T
        • Kirilmaz B
        • Onder R.
        Myocardial infarction following a bee sting.
        Int J Cardiol. 2001; 80: 251-253
        • Levine HD.
        Acute myocardial infarction following wasp sting. Report of two cases and critical survey of the literature.
        Am Heart J. 1976; 91: 365-374
        • Schiano P
        • Bourgeois B
        • Richard P
        • Belaouchi F
        • Monsegu J
        • Allouch P
        • et al.
        Allergic reaction to iodine-containing contrast medium complicated by occlusive coronary vasospasm during coronary arteriography.
        Ann Cardiol Angiol. 2002; 51 (French): 382-385
        • Vigorito C
        • Giordano A
        • De Caprio L
        • Vitale DF
        • Maurea N
        • Silvestri P
        • et al.
        Effects of histamine on coronary hemodynamics in humans: role of H1 and H2 receptors.
        J Am Coll Cardiol. 1987; 10: 1207-1213
        • Vigorito C
        • Giordano A
        • Cirillo R
        • Genovese A
        • Regno F
        • Marone G.
        Metabolic and hemodynamic effects of peptide leukotriene C4 and D4 in man.
        Int J Clin Lab Res. 1997; 27: 178-184
        • Bautista E
        • Simons FE
        • Simons KJ
        • Becker AB
        • Duke K
        • Tillett M
        • et al.
        Epinephrine fails to hasten hemodynamic recovery in fully developed canine anaphylactic shock.
        Int Arch Allergy Immunol. 2002; 128: 151-164
        • Tsuda A
        • Tanaka KA
        • Huraux C
        • Szlam F
        • Sato N
        • Yamaguchi K
        • et al.
        The in vitro reversal of histamine-induced vasodilation in the human internal mammary artery.
        Anesth Analg. 2001; 93: 1453-1459
        • Smith P
        • Kagey-Sobotka A
        • Bleecker ER
        • Traystman R
        • Kaplan AP
        • Gralnick H
        • et al.
        Physiologic manifestations of human anaphylaxis.
        J Clin Invest. 1980; 66: 1072-1080