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Long-term follow-up of oral immunotherapy for cow's milk allergy

      Oral immunotherapy (OIT) for food allergy is currently under active investigation, and its use in clinical practice is spreading despite important concerns.
      • Wasserman R.L.
      • Sugerman R.W.
      • Mireku-Akomeah N.
      • Mansfield L.
      • Baker J.W.
      Office-based oral immunotherapy for food allergy is safe and effective.
      • Sampson H.A.
      Peanut oral immunotherapy: is it ready for clinical practice?.
      Among the many reasons for caution is the paucity of data on long-term outcomes. One study in Italy found that although 18 (86%) of 21 subjects were initially partially or completely desensitized to cow's milk (CM) with OIT, this decreased to 14 (70%) of 20 after 4½ years.
      • Meglio P.
      • Giampietro P.G.
      • Gianni S.
      • Galli E.
      Oral desensitization in children with immunoglobulin E-mediated cow's milk allergy—follow-up at 4 yr and 8 months.
      Other studies have generally reported limited or no follow-up data. Here we report follow-up of 2 studies of CM OIT after up to 5 years to evaluate ongoing CM consumption, symptoms, and potential predictors of long-term outcomes.
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