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Allergy to green coffee

Failure of patients allergic to green coffee to react to chlorogenic acid, roasted coffee, or orange
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      Abstract

      Clinical skin tests upon twenty-nine French patients and allergic human serum transfer tests in monkeys indicate that primary allergy to green coffee does not involve chlorogenic acid or its known isomers. Allergy to green coffee appears to be a typical example of atopic hypersensitivity to proteins specific, in this allergy, to the green coffee bean. There were no cross-reactions to castor beans or oranges, nor were there any reaginic reactions to roasted coffee or to coffee beverage.

      References

        • Freedman S.O.
        • Krupey J.
        • Sehon A.H.
        Chlorogenic Acid: An Allergen in Green Coffee Bean.
        Nature. 1961; 192: 241
        • Freedman S.O.
        • Siddiqi A.I.
        • Krupey J.
        • Sehon A.H.
        Identification of a Simple Chemical Compound (Chlorogenic Acid) as an Allergen in Plant Materials Causing Human Atopic Disease.
        Am. J. M. Sc. 1962; 244: 548
        • Siddiqi A.I.
        • Freedman S.O.
        Identification of Chlorogenic Acid in Castor Bean and Oranges.
        Canad. J. Biochem. & Physiol. 1963; 41: 947
        • Freedman S.O.
        • Shulman R.
        • Krupey J.
        • Sehon A.H.
        Antigenic Properties of Chlorogenic Acid.
        J. Allergy. 1964; 35: 97
        • Freedman S.O.
        • Shulman R.
        • Krupey J.
        Loss of Allergenicity of Chlorogenic Acid in the Gastrointestinal Tract.
        J. Allergy. 1964; 35: 108
        • Layton L.L.
        • Lee S.
        • DeEds F.
        Diagnosis of Human Allergy Utilizing Passive Skin-Sensitization in the Monkey Macaca irus.
        in: Proc. Soc. Exper. Biol. & Med. 108. 1961: 623
        • Layton L.L.
        • Lee S.
        • Yamanaka E.
        • Greene F.C.
        • Green T.W.
        Allergy Skin Tests Upon Castor Bean-Sensitive Humans and Passively Sensitized Cynomolgus Monkeys.
        Internat. Arch. Allergy. 1962; 20: 257
        • Layton L.L.
        • Yamanaka E.
        • Greene F.C.
        Use of Monkeys to Demonstrate Allergic Cross-Reactions Among the Euphorbiaceae: Ricinus communis, Poinsettia pulcherrima, and Euphorbia esula.
        J. Allergy. 1962; 33: 276
        • Layton L.L.
        • Panzani R.
        • Greene F.C.
        • Green T.W.
        Castor Bean Allergy as Cross-Reactive Hypersensitivity to the Spurges (Euphorbiaceae): Absence of Reactions to Chlorogenic Acid in Primary Allergy to Castor Beans.
        Internat. Arch. Allergy. 1963; 23: 225
        • Sondheimer E.
        • Szymanski C.D.
        • Corse J.W.
        Isolation of Chlorogenic Acid and Its Isomers From Coffee.
        J. Agr. Food Chem. 1961; 9: 146
        • Corse J.W.
        A New Isomer of Chlorogenic Acid From Peaches.
        Nature. 1953; 172: 771
        • Moores R.G.
        • McDermott D.L.
        • Wood T.R.
        Determination of Chlorogenic Acid in Coffee.
        Anal. Chem. 1948; 20: 620