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Antigenic properties of chlorogenic acid

  • Samuel O. Freedman
    Affiliations
    From the McGill University Medical Clinic of the Montreal General Hospital, Montreal, Quebec, Canada

    the Department of Biochemistry, McGill University, Montreal, Quebec, Canada

    the Department of Chemistry, McGill University, Montreal, Quebec, Canada
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  • Robert Shulman
    Affiliations
    From the McGill University Medical Clinic of the Montreal General Hospital, Montreal, Quebec, Canada

    the Department of Biochemistry, McGill University, Montreal, Quebec, Canada

    the Department of Chemistry, McGill University, Montreal, Quebec, Canada
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  • John Krupey
    Affiliations
    From the McGill University Medical Clinic of the Montreal General Hospital, Montreal, Quebec, Canada

    the Department of Biochemistry, McGill University, Montreal, Quebec, Canada

    the Department of Chemistry, McGill University, Montreal, Quebec, Canada
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  • A.H. Sehon
    Affiliations
    From the McGill University Medical Clinic of the Montreal General Hospital, Montreal, Quebec, Canada

    the Department of Biochemistry, McGill University, Montreal, Quebec, Canada

    the Department of Chemistry, McGill University, Montreal, Quebec, Canada
    Search for articles by this author
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      Abstract

      Rabbits sensitized to chlorogenic acid by means of intramuscular and foot pad injections with chlorogenic acid emulsified in complete Freund's adjuvant showed positive Arthus reactions to chlorogenic acid and to green coffee extract. Sera obtained from the sensitized rabbits gave positive PCA reactions to chlorogenic acid and contained hemagglutinating and precipitating antibodies to green coffee extract. Guinea pigs sensitized to chlorogenic acid developed active systemic anaphylaxis when challenged with an intracardiac injection of chlorogenic acid. These findings lend further support to the hypothesis that chlorogenic acid is an important simple chemical sensitizer responsible for human respiratory allergy to certain types of plant materials.
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