- 1.1. β-dimethylaminoethyl benzhydryl ether hydrochloride (Benadryl) is a useful drug in the treatment of allergic diseases. It relieved 60 per cent of 223 patients presenting a variety of allergic symptoms.
- 2.2. It is entirely palliative in action, and withdrawal is followed by recurrence of symptoms.
- 3.3. Its effect was variable and frequently unpredictable in the same patient.
- 4.4. It was not very effective in asthma complicated by a respiratory infection. It was least effective in allergic rhinitis.
- 5.5. It was very useful in urticaria and for the control of pruritis in the allergic dermatoses.
- 6.6. Side reactions were frequently encountered, occurring in 63 per cent of the patients. The chief side reaction was drowsiness of varying degree up to narcolepsy. One-half the patients developing reactions had to discontinue the drug. The tendency to side reactions was frequently overcome by continuation of the drug with reduced dosages.
- 7.7. Side reactions were unpredictable, not always occurring in the same patient, one patient with allergic rhinitis, and two with migraine.
- 8.8. The drug produced an aggravation of symptoms in four asthmatic patients, one patient with allergic rhinitis, and two with migraine.
- 9.9. A tolerance was developed by two patients with urticaria who were at first definitely relieved by the drug.
- 10.10. The drug did not appreciably influence the scratch test for ragweed carried out twenty minutes after the ingestion of 100 milligrams.
- 11.11. The drug should be of considerable value in those patients able to tolerate it for the control of symptoms while allergic investigations are being carried out.
Personal communication to the authors by the Department of Clinical Investigation, Parke, Davis and Company, Detroit, Mich.
- Synthetic Benzhydryl Alkaline Ethers Effective in Preventing Fatal Experimental Asthma in Guinea Pigs Subjected to Vaporized Histamine.J. Pharmacol. & Exper. Therap. 1945; 83: 120
- Alleviation of Anaphylactic Shock in Guinea Pigs With Synthetic Benzhydryl Alkamine Ethers.in: Proc. Soc. Exper. Biol. & Med. 58. 1945: 235
- Beta-Dimethyl Aminoethyl Benzhydryl Ether Hydrochloride (Benadryl) in the Treatment of Acute and Chronic Urticaria.Univ. Hosp. Bull. Ann Arbor. 1945; 2: 25
- Relief of Dermographism and Other Urticarias of Histamine Origin by a Synthetic Benzhydryl Alkamine Ether.J. Allergy. 1945; 15: 296
☆Read as part of a symposium on antihistaminic drugs at the Second Annual Meeting of the American Academy of Allergy, Chicago, Ill., Dec. 11, 1945.