Articles & Issues

For this month's interview, we talked with Stuart L. Abramson, MD, PhD, AE-C, FAAAAI, the incoming chair of the Annual Meeting Program Committee (AMPC). Dr. Abramson leads the Allergy/Immunology Servi...

Previous research on reslizumab, an anti–IL-5 mAb, in asthmatic patients did not provide a clear clinical benefit; however, improvements were noted in small studies in subgroups of patients with eosin...

Asthma is a common disorder that in 2009 afflicted 8.2% of adults and children, 24.6 million persons, in the United States. In patients with moderate and severe persistent asthma, there is significant...

Mucocutaneous candidiasis and dermatophyte infections occur either in isolation or alongside other symptoms in patients with various primary immunodeficiency diseases with diverse genetic defects, whi...

Background: There are a limited number of publications on the management of gynecologic/obstetric events in female patients with hereditary angioedema caused by C1 inhibitor deficiency (HAE-C1-INH). O...

Access to an electronic medical record is essential for personalized medicine. Currently, only 40% of US physicians have such access, but this is rapidly changing. It is expected that 100,000 American...

Investigations of basic immunologic mechanisms and clinical studies of primary immunodeficiencies were most prevalent in 2011. Significant progress was achieved in the characterization of TH17 cell di...

Background: Airway disorders are common in regular chlorinated swimming pool attendees, particularly competitive athletes, but the impact of intense swimming training on airway function and structure ...

Background: It has recently been shown that vitamin D deficiency can increase asthma development and severity and that variations in vitamin D receptor genes are associated with asthma susceptibility....

Background: The clinical relevance of increased ventilation heterogeneity, a marker of small-airways disease, in asthmatic patients is unclear. Ventilation heterogeneity is an independent determinant ...

With regard to the August 2011 article entitled “Tiotropium is noninferior to salmeterol in maintaining improved lung function in B16-Arg/Arg patients with asthma” (J Allergy Clin Immunol 2011;128:315...

Background: Not much data are available from large, unselected, birth cohort studies on the natural course and comorbidities of rhinitis in children. Objective: To study phenotypes of rhinitis in rela...

Background: Subcutaneous allergen-specific immunotherapy (SCIT) is a well-documented treatment of IgE-mediated allergic disease. Little is known about potential effects of SCIT on the risk of other ch...

Background: Atopic dermatitis (AD) is an inflammatory skin disease affecting 10% to 20% of children and 1% to 3% of adults in industrialized countries. Enhanced expression of IL-31 is detected in skin...

The importance of the human microbiome is rapidly emerging. Our bodies host complex communities of microbes with much greater genetic diversity than our own genome. This complexity is variable across ...

Background: Oral immunotherapy (OIT) and sublingual immunotherapy (SLIT) are potential therapies for food allergy, but the optimal method of administration, mechanism of action, and duration of respon...

Background: Autoimmune polyendocrinopathy–candidiasis–ectodermal dystrophy (APECED) syndrome is a complex immunologic disease caused by mutation of the autoimmune regulator (AIRE) gene. Autoimmunity i...

Background: The inhalation of diesel exhaust particles (DEPs) is associated with increased sensitization toward inhaled allergens. Dendritic cells (DCs) are important mediators in immune regulation. W...

Background: The uptake and processing of blood coagulation factor VIII (FVIII) by antigen-presenting cells and the subsequent presentation of FVIII-derived peptides to CD4+ T cells direct the immune r...

Background: Based on their potency to control allergic diseases, regulatory T (Treg) cells represent a promising target for novel strategies to interfere with allergic airway inflammation. We have pre...

Background: Eosinophilic pustular folliculitis (EPF) is a chronic intractable pruritic dermatosis characterized by massive eosinophil infiltrates involving the pilosebaceous units. Recently, EPF has b...

To date, allergen-specific immunotherapy (ASIT) is the only causal treatment for allergic diseases. The principle of ASIT is to administer gradually increasing doses of allergen, either as allergen ex...

The “F-ring” urinary prostaglandin D2 (PGD2) metabolites—9α,11β-prostaglandin F2 (9α,11β-PGF2), 2,3-dinor-9α,11β-prostaglandin F2 (2,3-dinor-9α,11β-PGF2), and 9α,11β-dihydroxy-15-oxo-2,3,18,19-tetrano...

Nitrile gloves are the alternative for health professionals sensitized to latex in case of biological risk or managing of chemical substances with irritating or toxic properties. There are very few re...

A substantial proportion of patients admitted to the hospital have a diagnosis of drug hypersensitivity (DH). However, this diagnosis may sometimes be inaccurate, causing deleterious medical and econo...

Asthma affects all age groups and presents itself as a spectrum of severity and symptoms. Reactive oxygen species (ROS) play a pivotal role in asthma pathogenesis. Exhaled levels of mediators associat...

Asthma is a chronic inflammatory disease associated with genetic and environmental factors. Although the 12q13-24 chromosome region had previously shown linkage to asthma, the IL-1 receptor–associated...

A patient presented to us with autosomal-dominant anhidrotic ectodermal dysplasia with immune deficiency syndrome (EDA-ID). By using a rapid flow cytometric screening system, we detected a novel mutat...