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Article Title |
Author(s) |
Type (Status) |
Available Online |
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Which disease is cured by Lactobacillus?
DOI: 10.1016/j.jaci.2011.12.997
We read with interest the article by Canani et al that evaluates the effect of Lactobacillus GG on tolerance acquisition in infants with cow's milk allergy (CMA). Their method of selection and classif...
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Michael Goldberg,
Yitzhak Katz
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Correspondence
(In Press Corrected Proof)
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10 February 2012 |
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Food protein–induced enterocolitis syndrome in an exclusively breast-fed infant—an uncommon entity
DOI: 10.1016/j.jaci.2011.12.1000
We read with interest the report by Monti et al of the only published case of food protein–induced enterocolitis syndrome (FPIES) triggered by cow's milk protein in breast milk. We can also report a c...
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John Tan,
Dianne Campbell,
Sam Mehr
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Correspondence
(In Press Corrected Proof)
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10 February 2012 |
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Reply
DOI: 10.1016/j.jaci.2011.12.1001
We read with great interest the comments by Tan et al regarding our case report of an exclusively breast-fed infant with food protein–induced enterocolitis syndrome (FPIES) to cow's milk proteins.
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Giovanna Monti,
Emanuele Castagno,
Stefania Alfonsina Liguori,
Maria Maddalena Lupica,
Valentina Tarasco,
Serena Viola
et al.
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Correspondence
(In Press Corrected Proof)
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10 February 2012 |
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The developmental trajectory of pediatric asthma in 3- to-10-year-olds
DOI: 10.1016/j.jaci.2012.01.029
Longitudinal studies have suggested that early childhood asthma follows different temporal trajectories. Children with early childhood recurrent wheezing frequently have “symptom- or disease-free” per...
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Pingsheng Wu,
Kecia N. Carroll,
Tebeb Gebretsadik,
William D. Dupont,
Edward F. Mitchel,
Tina V. Hartert
et al.
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Short communication
(In Press Corrected Proof)
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10 February 2012 |
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A fascinating look at the world with a new microscope
DOI: 10.1016/j.jaci.2011.12.994
In the mid-17th century in Delft, Antony Leeuwenhoek was the first to invent the microscope. He was enormously skilled in making lenses and mounted them on frames that would eventually become the firs...
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Erika von Mutius
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Editorial
(In Press Corrected Proof)
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10 February 2012 |
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Reply
DOI: 10.1016/j.jaci.2011.12.999
We are replying to the comments of Drs Goldberg and Katz regarding our article in which we described the effect of Lactobacillus GG supplementation to an extensively hydrolyzed casein formula on toler...
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Roberto Berni Canani,
Rita Nocerino,
Gianluca Terrin,
Anna Coruzzo,
Linda Cosenza,
Ludovica Leone,
Riccardo Troncone
et al.
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Correspondence
(In Press Corrected Proof)
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10 February 2012 |
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Prevalence of eczema and food allergy is associated with latitude in Australia
DOI: 10.1016/j.jaci.2012.01.037
Recent reports from both Australia and the United States suggest that vitamin D might play a role in the recent increase in allergic disease, in particular food allergy. Using indirect markers of food...
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Nicholas J. Osborne,
Obioha C. Ukoumunne,
Melissa Wake,
Katrina J. Allen
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Short communication
(In Press Corrected Proof)
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10 February 2012 |
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High prevalence of asthma in HIV-infected adults: New insights
DOI: 10.1016/j.jaci.2012.01.035
Over the past decade, many new insights into asthma pathophysiology have been reported in the Journal and elsewhere complemented by reports of increasingly sophisticated therapeutic approaches. Distur...
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William T. Shearer,
David B. Corry
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Editorial
(In Press Corrected Proof)
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10 February 2012 |
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Direct interaction between HLA-B and carbamazepine activates T cells in patients with Stevens-Johnson syndrome
DOI: 10.1016/j.jaci.2011.12.990
Background: Increasing studies have revealed that HLA alleles are the major genetic determinants of drug hypersensitivity; however, the underlying molecular mechanism remains unclear. Objective: We ad...
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Chun-Yu Wei,
Wen-Hung Chung,
Hsiao-Wen Huang,
Yuan-Tsong Chen,
Shuen-Iu Hung
et al.
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Full-length article
(In Press Corrected Proof)
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10 February 2012 |
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Advances in upper airway diseases and allergen immunotherapy in 2011
DOI: 10.1016/j.jaci.2012.01.050
The purpose of this review is to highlight recently published important articles on upper airway diseases and allergen immunotherapy. We review articles on rhinitis, sinusitis, conjunctivitis, and imm...
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Joy Hsu,
Carol A. Saltoun,
Pedro C. Avila
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Full-length article
(In Press Corrected Proof)
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10 February 2012 |
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IgE against bed bug (Cimex lectularius) allergens is common among adults bitten by bed bugs
DOI: 10.1016/j.jaci.2012.01.034
Cimex lectularius, the bed bug, is found worldwide and likely has been sharing human dwellings dating back to prehistoric times. With increased use of pesticides after World War II, the reports of bed...
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Jason B. Price,
Adnan Divjan,
William R. Montfort,
Kirstie H. Stansfield,
Greg A. Freyer,
Matthew S. Perzanowski
et al.
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Short communication
(In Press Corrected Proof)
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10 February 2012 |
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Gut matters: Microbe-host interactions in allergic diseases
DOI: 10.1016/j.jaci.2011.12.993
The human body can be considered a metaorganism made up of its own eukaryotic cells and trillions of microbes that colonize superficial body sites, such as the skin, airways, and gastrointestinal trac...
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Gabriele Hörmannsperger,
Thomas Clavel,
Dirk Haller
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Full-length article
(In Press Corrected Proof)
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10 February 2012 |
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Pneumococcal polysaccharide vaccine at 12 months of age produces functional immune responses
DOI: 10.1016/j.jaci.2011.11.043
Background: Infections with Streptococcus pneumoniae (pneumococcus) are a cause of significant child mortality. Pneumococcal glycoconjugate vaccines are expensive and provide limited serotype coverage...
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Paul V. Licciardi,
Anne Balloch,
Fiona M. Russell,
Robert L. Burton,
Jisheng Lin,
Moon H. Nahm,
Edward K. Mulholland,
Mimi L.K. Tang
et al.
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Full-length article
(In Press Corrected Proof)
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10 February 2012 |
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Sputum matrix metalloproteinase-12 in patients with chronic obstructive pulmonary disease and asthma: Relationship to disease severity
DOI: 10.1016/j.jaci.2011.12.996
Background: Matrix metalloproteinase (MMP)-12 has been implicated in the pathogenesis of both chronic obstructive pulmonary disease (COPD) and asthma. The influence of disease severity on sputum MMP-1...
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Rekha Chaudhuri,
Charles McSharry,
Jeffrey Brady,
Iona Donnelly,
Christal Grierson,
Stephen McGuinness,
Lisa Jolly,
Christopher J. Weir,
C. Martina Messow,
Mark Spears,
Gino Miele,
Karl Nocka,
Dan Crowther,
Joyce Thompson,
Maureen Brannigan,
Jane Lafferty,
Michael Sproule,
William MacNee,
Martin Connell,
John T. Murchison,
Malcolm C. Shepherd,
Giora Feuerstein,
Douglas K. Miller,
Neil C. Thomson
et al.
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Full-length article
(In Press Corrected Proof)
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10 February 2012 |
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Diagnosing nonimmediate reactions to cephalosporins
DOI: 10.1016/j.jaci.2011.12.995
Like penicillins, cephalosporins can cause nonimmediate reactions (ie, occurring >1 hour and within 7 days after the last drug administration). The main nonimmediate reactions are maculopapular or ...
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Antonino Romano,
Francesco Gaeta,
Rocco Luigi Valluzzi,
Cristiano Caruso,
Cristiana Alonzi,
Marinella Viola,
Philippe Jean Bousquet
et al.
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Short communication
(In Press Corrected Proof)
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10 February 2012 |
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Filaggrin loss-of-function mutations are associated with enhanced expression of IL-1 cytokines in the stratum corneum of patients with atopic dermatitis and in a murine model of filaggrin deficiency
DOI: 10.1016/j.jaci.2011.12.989
Background: Filaggrin (FLG) mutations result in reduced stratum corneum (SC) natural moisturizing factor (NMF) components and consequent increased SC pH. Because higher pH activates SC protease activi...
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Sanja Kezic,
Gráinne M. O’Regan,
René Lutter,
Ivone Jakasa,
Ellen S. Koster,
Sean Saunders,
Peter Caspers,
Patrick M.J.H. Kemperman,
Gerwin J. Puppels,
Aileen Sandilands,
Huijia Chen,
Linda E. Campbell,
Karin Kroboth,
Rosemarie Watson,
Padraic G. Fallon,
W. H. Irwin McLean,
Alan D. Irvine
et al.
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Full-length article
(In Press Corrected Proof)
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10 February 2012 |
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Potter Stewart and the definition of anaphylaxis
DOI: 10.1016/j.jaci.2012.01.030
Potter Stewart was an Associate Justice of the US Supreme Court who might be best known for a snippet from his opinion in the obscenity case of Jacobellis v Ohio (1964). In that case he acknowledged t...
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Carlos A. Camargo
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Editorial
(In Press Corrected Proof)
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30 January 2012 |
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Remembrance of things past: HLA genes come back on the allergy stage
DOI: 10.1016/j.jaci.2011.12.998
Like most other research fields, immunology has witnessed the rise and fall of many paradigms. In the 1970s and early 1980s, the emphasis was on antigen-specific responses and the molecules underpinni...
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Donata Vercelli
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Editorial
(In Press Corrected Proof)
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30 January 2012 |
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SQ-standardized sublingual grass immunotherapy: Confirmation of disease modification 2 years after 3 years of treatment in a randomized trial
DOI: 10.1016/j.jaci.2011.12.973
Background: The main aim of specific immunotherapy is sustained effect due to changes in the immune system that can be demonstrated only in long-term trials. Objective: To investigate sustained effica...
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Stephen R. Durham,
Waltraud Emminger,
Alexander Kapp,
Jan G.R. de Monchy,
Sabina Rak,
Glenis K. Scadding,
Peter A. Wurtzen,
Jens S. Andersen,
Bente Tholstrup,
Bente Riis,
Ronald Dahl
et al.
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Full-length article
(In Press Corrected Proof)
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30 January 2012 |
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Clinical relevance of IgE to recombinant Gly m 4 in the diagnosis of adult soybean allergy
DOI: 10.1016/j.jaci.2012.01.031
Soybean is one of the most important foods causing food allergy in childhood. In addition, studies have shown that allergy to soybean can be caused by IgE cross-reactivity between Bet v 1, a major all...
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Yuma Fukutomi,
Sigrid Sjölander,
Takuya Nakazawa,
Magnus P. Borres,
Toyota Ishii,
Satoshi Nakayama,
Akira Tanaka,
Masami Taniguchi,
Akemi Saito,
Hiroshi Yasueda,
Hiroyuki Nakamura,
Kazuo Akiyama
et al.
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Short communication
(In Press Corrected Proof)
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30 January 2012 |
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Laboratory technology for population-based screening for severe combined immunodeficiency in neonates: The winner is T-cell receptor excision circles
DOI: 10.1016/j.jaci.2012.01.032
The most profound primary immunodeficiency disease, severe combined immunodeficiency (SCID), is fatal in infancy unless affected infants are provided with an adaptive immune system through allogeneic ...
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Jennifer M. Puck
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Review article
(In Press Corrected Proof)
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30 January 2012 |
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Specific allergen concentration of WHO and FDA reference preparations measured using a multiple allergen standard
DOI: 10.1016/j.jaci.2011.12.978
Allergen measurements require well-defined allergen standards. Allergists rely on these measurements for dosing patients on immunotherapy with the aim of achieving maintenance doses of 5 to 20 μg of s...
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Stephanie Filep,
Amy Tsay,
Lisa D. Vailes,
Gabriele Gadermaier,
Fatima Ferreira,
Elizabeth Matsui,
Eva M. King,
Martin D. Chapman
et al.
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Short communication
(In Press Corrected Proof)
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27 January 2012 |
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High sensitivity of CAP-FEIA rVes v 5 and rVes v 1 for diagnosis of Vespula venom allergy
DOI: 10.1016/j.jaci.2011.12.975
Ves v 5 (antigen 5) is a 23-kDa protein from Vespula venom, and it is recognized as the most potent allergen in venoms of the Vespidae family. There is a high sequence similarity of Ves v 5 within spe...
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Peter Korošec,
Rudolf Valenta,
Irene Mittermann,
Nina Čelesnik,
Mira Šilar,
Mihaela Zidarn,
Mitja Košnik
et al.
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Short communication
(In Press Corrected Proof)
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27 January 2012 |
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Screening for severe combined immunodeficiency in newborns
DOI: 10.1016/j.jaci.2011.12.992
This issue of the Journal is devoted to the critical concept of screening for severe combined immunodeficiency (SCID), a long-sought goal of clinical immunologists engaged in hematopoietic stem cell t...
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William T. Shearer
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Editorial
(In Press Corrected Proof)
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27 January 2012 |
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CD21 deficiency, complement, and the development of common variable immunodeficiency
DOI: 10.1016/j.jaci.2011.12.982
In this issue, Thiel and colleagues present the first patient identified who lacks the membrane receptor protein CD21. This receptor is mainly present on B cells and follicular dendritic cells. In thi...
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Michael M. Frank
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Editorial
(In Press Corrected Proof)
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27 January 2012 |
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The relationship between combination inhaled corticosteroid and long-acting β-agonist use and severe asthma exacerbations in a diverse population
DOI: 10.1016/j.jaci.2011.12.974
Background: Safety concerns surround the use of long-acting β-agonists (LABAs) for the treatment of asthma, even in combination with inhaled corticosteroids (ICSs) and particularly in high-risk subgro...
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Karen E. Wells,
Edward L. Peterson,
Brian K. Ahmedani,
Richard K. Severson,
Julie Gleason-Comstock,
L. Keoki Williams
et al.
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Full-length article
(In Press Corrected Proof)
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27 January 2012 |
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Significance of ovomucoid- and ovalbumin-specific IgE/IgG4 ratios in egg allergy
DOI: 10.1016/j.jaci.2011.11.053
Background: The role of specific IgG4 antibodies in natural tolerance acquisition remains a matter of debate; the specific IgE/IgG4 ratio might add value to the measurement of absolute amounts of IgE ...
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Jean Christoph Caubet,
Ramon Bencharitiwong,
Erin Moshier,
James H. Godbold,
Hugh A. Sampson,
Anna Nowak-Węgrzyn
et al.
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Full-length article
(In Press Corrected Proof)
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27 January 2012 |
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The long quest for neonatal screening for severe combined immunodeficiency
DOI: 10.1016/j.jaci.2011.12.964
Early recognition of severe combined immunodeficiency (SCID) is a pediatric emergency because a diagnosis before live vaccines or nonirradiated blood products are given and before development of infec...
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Rebecca H. Buckley
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Review article
(In Press Corrected Proof)
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27 January 2012 |
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Activin A and TGF-β promote TH9 cell–mediated pulmonary allergic pathology
DOI: 10.1016/j.jaci.2011.12.965
Background: IL-9–secreting (TH9) T cells are thought to represent a distinct T-cell subset. However, evidence for their functionality in disease is uncertain. Objective: To define a functional phenoty...
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Carla P. Jones,
Lisa G. Gregory,
Benjamin Causton,
Gaynor A. Campbell,
Clare M. Lloyd
et al.
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Full-length article
(In Press Corrected Proof)
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27 January 2012 |
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DNA methylation of TH1/TH2 cytokine genes affects sensitization and progress of experimental asthma
DOI: 10.1016/j.jaci.2011.12.963
Background: Epigenetic changes in DNA methylation have recently been demonstrated to be involved in effector T-cell polarization, resulting in differential secretion of TH1 and TH2 cytokines. However,...
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Stephanie Brand,
Dörthe Andrea Kesper,
René Teich,
Esma Kilic-Niebergall,
Olaf Pinkenburg,
Evita Bothur,
Michael Lohoff,
Holger Garn,
Petra Ina Pfefferle,
Harald Renz
et al.
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Full-length article
(In Press Corrected Proof)
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27 January 2012 |
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Reduction of total IgE by targeted coengagement of IgE B-cell receptor and FcγRIIb with Fc-engineered antibody
DOI: 10.1016/j.jaci.2011.11.029
Background: Sequestration of IgE to prevent its binding to high-affinity IgE receptor FcεRI on basophils and mast cells is an effective therapy for allergic asthma. IgE production requires differentia...
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Seung Y. Chu,
Holly M. Horton,
Erik Pong,
Irene W.L. Leung,
Hsing Chen,
Duc-Hanh Nguyen,
Cristina Bautista,
Umesh S. Muchhal,
Matthew J. Bernett,
Gregory L. Moore,
David E. Szymkowski,
John R. Desjarlais
et al.
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Full-length article
(In Press Corrected Proof)
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18 January 2012 |
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Reply
DOI: 10.1016/j.jaci.2011.11.049
In response to our recent report of a case of anaphylaxis in an allergy immunotherapy extract-compounding technician after an extract needle stick, we want to thank Dr Dreborg for sharing his own simi...
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Michelle L. Bandino,
Michael S. Tankersley
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Correspondence
(In Press Corrected Proof)
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13 January 2012 |
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The risk of allergic reactions to allergen extracts in personnel
DOI: 10.1016/j.jaci.2011.11.048
I would like to comment on the interesting letter to the Editor by Bandino and Tankersley.
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Sten Dreborg
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Correspondence
(In Press Corrected Proof)
|
13 January 2012 |
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Obesity is not linked to increased whole-body mast cell burden in children
DOI: 10.1016/j.jaci.2011.11.050
Obesity is clearly associated with insulin resistance and chronic low-grade inflammation. Macrophages appear to be especially important in this relationship because they infiltrate adipose tissue and ...
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Brant R. Ward,
Silva A. Arslanian,
Elisa Andreatta,
Lawrence B. Schwartz
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Short communication
(In Press Corrected Proof)
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13 January 2012 |
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The Wisconsin approach to newborn screening for severe combined immunodeficiency
DOI: 10.1016/j.jaci.2011.12.004
Severe combined immunodeficiency (SCID) is a life-threatening disease of infants that is curable with hematopoietic cell transplantation if detected early. Population-based screening for SCID using th...
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James Verbsky,
Monica Thakar,
John Routes
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Full-length article
(In Press Corrected Proof)
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13 January 2012 |
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Nationwide cohort study of the leukotriene receptor antagonist montelukast and incident or recurrent cardiovascular disease
DOI: 10.1016/j.jaci.2011.11.052
Background: The leukotriene pathway has been associated with an increased cardiovascular risk. However, the effects of the antileukotriene treatment used in asthmatic patients on cardiovascular outcom...
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Erik Ingelsson,
Li Yin,
Magnus Bäck
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Full-length article
(In Press Corrected Proof)
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13 January 2012 |
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Development and validation of the Composite Asthma Severity Index—an outcome measure for use in children and adolescents
DOI: 10.1016/j.jaci.2011.12.962
Background: Asthma severity is reflected in many aspects of the disease, including impairment and future risks, particularly for exacerbations. According to the Expert Panel Report 3: Guidelines for t...
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Jeremy J. Wildfire,
Peter J. Gergen,
Christine A. Sorkness,
Herman E. Mitchell,
Agustin Calatroni,
Meyer Kattan,
Stanley J. Szefler,
Stephen J. Teach,
Gordon R. Bloomberg,
Robert A. Wood,
Andrew H. Liu,
Jacqueline A. Pongracic,
James F. Chmiel,
Kathleen Conroy,
Yadira Rivera-Sanchez,
Wayne J. Morgan,
William W. Busse
et al.
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Full-length article
(In Press Corrected Proof)
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13 January 2012 |
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Multiple-allergen and single-allergen immunotherapy strategies in polysensitized patients: Looking at the published evidence
DOI: 10.1016/j.jaci.2011.11.019
In allergen immunotherapy there is debate as to whether polysensitized patients are best treated with many allergens simultaneously (chosen according to the sensitization profile, a predominantly Nort...
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Moisés A. Calderón,
Linda Cox,
Thomas B. Casale,
Philippe Moingeon,
Pascal Demoly
et al.
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Full-length article
(In Press Corrected Proof)
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13 January 2012 |
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Possible eosinophilic esophagitis induced by milk oral immunotherapy
DOI: 10.1016/j.jaci.2011.11.042
New therapeutic strategies to treat food allergy have emerged in recent years. At present, oral immunotherapy (OIT) with food is one of the most widely researched treatments for food allergy. Immediat...
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Silvia Sánchez-García,
Pablo Rodríguez del Río,
Carmelo Escudero,
M. Jose Martínez-Gómez,
M. Dolores Ibáñez
et al.
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Short communication
(In Press Corrected Proof)
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11 January 2012 |
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Administration of influenza vaccine to pediatric patients with egg-induced anaphylaxis
DOI: 10.1016/j.jaci.2011.11.038
Administration of egg-containing influenza vaccine to subjects with egg allergy continues to generate discourse. From a public health perspective, vaccination offers clear benefits. However, the poten...
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Irene Fung,
Jonathan M. Spergel
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Short communication
(In Press Corrected Proof)
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11 January 2012 |
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Age-related differences in the pathogenesis of chronic rhinosinusitis
DOI: 10.1016/j.jaci.2011.12.002
Chronic rhinosinusitis (CRS) significantly affects the quality of life of elderly people. However, the inflammatory mechanisms of CRS in the elderly have not been well studied. CRS is commonly divided...
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Seong H. Cho,
Seung J. Hong,
Brian Han,
Sun H. Lee,
Lydia Suh,
James Norton,
David Lin,
David B. Conley,
Rakesh Chandra,
Robert C. Kern,
Bruce K. Tan,
Atsushi Kato,
Anju Peters,
Leslie C. Grammer,
Robert P. Schleimer
et al.
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Short communication
(In Press Corrected Proof)
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11 January 2012 |
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Increased peanut-specific IgA levels in saliva correlate with food challenge outcomes after peanut sublingual immunotherapy
DOI: 10.1016/j.jaci.2011.11.045
Antigen-specific immunotherapy has been practiced for 100 years and is the only known therapy that modulates IgE-mediated allergy. Immunotherapy is commonly administered through the subcutaneous (SCIT...
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Michael Kulis,
Katie Saba,
Edwin H. Kim,
J. Andrew Bird,
Nikolas Kamilaris,
Brian P. Vickery,
Herman Staats,
A. Wesley Burks
et al.
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Short communication
(In Press Corrected Proof)
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11 January 2012 |
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Pancreatitis as a novel complication of aspirin therapy in patients with aspirin-exacerbated respiratory disease
DOI: 10.1016/j.jaci.2011.12.003
Aspirin-exacerbated respiratory disease (AERD), previously termed Samter triad, is an adult-onset disease characterized by asthma, hyperplastic chronic sinusitis, nasal polyposis, and hypersensitivity...
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Flavia C.L. Hoyte,
Richard W. Weber,
Rohit K. Katial
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Short communication
(In Press Corrected Proof)
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11 January 2012 |
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Recurrent severe exacerbations in early life and reduced lung function at school age
DOI: 10.1016/j.jaci.2011.11.046
Asthma exacerbations have been linked to progressive loss of lung function in school-age children and adults. Previous longitudinal studies have suggested that lung function deficits in children with ...
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Amy L. O’Brian,
Robert F. Lemanske,
Michael D. Evans,
Ronald E. Gangnon,
James E. Gern,
Daniel J. Jackson
et al.
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Short communication
(In Press Corrected Proof)
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11 January 2012 |
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Usefulness of PBMCs to predict clinical response to corticosteroids in asthmatic patients
DOI: 10.1016/j.jaci.2011.12.001
Background: Blood tests are needed to identify steroid-resistant (SR) asthmatic patients early so that they can be managed with alternative anti-inflammatory therapy. Objective: We sought to assess th...
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Elena Goleva,
Leisa P. Jackson,
Melanie Gleason,
Donald Y.M. Leung
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Full-length article
(In Press Corrected Proof)
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11 January 2012 |
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Allergen-induced IgE-dependent gut inflammation in a human PBMC–engrafted murine model of allergy
DOI: 10.1016/j.jaci.2011.11.036
Background: Humanized murine models comprise a new tool to analyze novel therapeutic strategies for allergic diseases of the intestine. Objective: In this study we developed a human PBMC–engrafted mur...
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Benno Weigmann,
Nadja Schughart,
Christian Wiebe,
Stephan Sudowe,
Hans A. Lehr,
Helmut Jonuleit,
Lothar Vogel,
Christoph Becker,
Markus F. Neurath,
Stephan Grabbe,
Joachim Saloga,
Iris Bellinghausen
et al.
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Full-length article
(In Press Corrected Proof)
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11 January 2012 |
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The airway epithelium nucleotide-binding domain and leucine-rich repeat protein 3 inflammasome is activated by urban particulate matter
DOI: 10.1016/j.jaci.2011.11.033
Background: The airway epithelium is the first line of defense against inhaled insults and therefore must be capable of coordinating appropriate inflammatory and immune responses. Objective: We sought...
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Jeremy A. Hirota,
Simon A. Hirota,
Stephanie M. Warner,
Dorota Stefanowicz,
Furquan Shaheen,
Paul L. Beck,
Justin A. MacDonald,
Tillie-Louise Hackett,
Don D. Sin,
Stephan Van Eeden,
Darryl A. Knight
et al.
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Full-length article
(In Press Corrected Proof)
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10 January 2012 |
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Airway epithelial cells from asthmatic children differentially express proremodeling factors
DOI: 10.1016/j.jaci.2011.11.035
Background: The airway epithelium can express factors that drive subepithelial airway remodeling. TGF-β2, vascular epithelial growth factor (VEGF), a disintegrin and metalloprotease 33 (ADAM33), and p...
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Jesus M. Lopez-Guisa,
Claire Powers,
Daniele File,
Elizabeth Cochrane,
Nathalia Jimenez,
Jason S. Debley
et al.
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Full-length article
(In Press Corrected Proof)
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10 January 2012 |
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Endocannabinoids limit excessive mast cell maturation and activation in human skin
DOI: 10.1016/j.jaci.2011.11.009
Background: Mast cells (MCs) crucially contribute to many inflammatory diseases. However, the physiological controls preventing excessive activities of MCs in human skin are incompletely understood. O...
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Koji Sugawara,
Tamás Bíró,
Daisuke Tsuruta,
Balázs I. Tóth,
Arno Kromminga,
Nóra Zákány,
Anne Zimmer,
Wolfgang Funk,
Bernhard F. Gibbs,
Andreas Zimmer,
Ralf Paus
et al.
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Full-length article
(In Press Corrected Proof)
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09 January 2012 |
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Increased risk of pertussis in patients with asthma
DOI: 10.1016/j.jaci.2011.11.020
Background: The recent pertussis outbreak in California highlights the effect of pertussis on public health. In 2004, a pertussis outbreak occurred in Olmsted County, Minnesota, despite a high vaccine...
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Conrad R. Capili,
Allison Hettinger,
Natalie Rigelman-Hedberg,
Lisa Fink,
Thomas Boyce,
Brian Lahr,
Young J. Juhn
et al.
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Full-length article
(In Press Corrected Proof)
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30 December 2011 |
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Molecular profiles of IgE to Phleum pratense in children with grass pollen allergy: Implications for specific immunotherapy
DOI: 10.1016/j.jaci.2011.10.045
Background: The so-called component-resolved immunotherapy of allergies proposes an immunization tailored to the molecular sensitization profiles of individual patients. Objectives: We sought (1) to i...
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Salvatore Tripodi,
Tullio Frediani,
Sandra Lucarelli,
Francesco Macrì,
Giuseppe Pingitore,
Andrea Di Rienzo Businco,
Arianna Dondi,
Paola Pansa,
Giovanni Ragusa,
Riccardo Asero,
Diego Faggian,
Mario Plebani,
Paolo Maria Matricardi
et al.
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Full-length article
(In Press Corrected Proof)
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30 December 2011 |
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CD27 deficiency is associated with combined immunodeficiency and persistent symptomatic EBV viremia
DOI: 10.1016/j.jaci.2011.11.013
Background: CD27 is a lymphocyte costimulatory molecule that regulates T-cell, natural killer (NK) cell, B-cell, and plasma cell function, survival, and differentiation. On the basis of its function a...
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Joris M. van Montfrans,
Andy I.M. Hoepelman,
Sigrid Otto,
Marielle van Gijn,
Lisette van de Corput,
Roel A. de Weger,
Linda Monaco-Shawver,
Pinaki P. Banerjee,
Elisabeth A.M. Sanders,
Cornelia M. Jol–van der Zijde,
Michael R. Betts,
Jordan S. Orange,
Andries C. Bloem,
Kiki Tesselaar
et al.
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Full-length article
(In Press Corrected Proof)
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26 December 2011 |
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Tolerance-like mediated suppression by mesenchymal stem cells in patients with dust mite allergy–induced asthma
DOI: 10.1016/j.jaci.2011.10.048
Background: Mesenchymal stem cells (MSCs) can suppress and enhance immune functions. MSCs show promise as off-the-shelf cellular therapy for several disorders, including inflammation. Objective: We in...
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Simi Kapoor,
Shyam A. Patel,
Saritha Kartan,
David Axelrod,
Eugenio Capitle,
Pranela Rameshwar
et al.
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Full-length article
(In Press Corrected Proof)
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26 December 2011 |
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Relating small airways to asthma control by using impulse oscillometry in children
DOI: 10.1016/j.jaci.2011.11.002
Background: Previous reports suggest that the peripheral airways are associated with asthma control. Patient history, although subjective, is used largely to assess asthma control in children because ...
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Yixin Shi,
Anna S. Aledia,
Ahramahzd V. Tatavoosian,
Shruthi Vijayalakshmi,
Stanley P. Galant,
Steven C. George
et al.
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Full-length article
(In Press Corrected Proof)
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19 December 2011 |
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The course of asthma activity: A population study
DOI: 10.1016/j.jaci.2011.11.014
Background: Unlike most chronic diseases, which tend to progress over time, asthma is known to persist, possibly resolve, and/or present with any combination of remissions and relapses. As a result, i...
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Andrea Gershon,
Jun Guan,
J. Charles Victor,
Chengning Wang,
Teresa To
et al.
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Full-length article
(In Press Corrected Proof)
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19 December 2011 |
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Asthma diagnosis and airway bronchodilator response in HIV-infected patients
DOI: 10.1016/j.jaci.2011.11.015
Background: Despite the high prevalence of respiratory symptoms and obstructive lung disease in HIV-infected subjects, the prevalence of bronchodilator reversibility (BDR) and asthma has not been syst...
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Matthew R. Gingo,
Sally E. Wenzel,
Chad Steele,
Cathy J. Kessinger,
Lorrie Lucht,
Tammi Lawther,
Michelle Busch,
Maria E. Hillenbrand,
Renee Weinman,
William A. Slivka,
Deborah K. McMahon,
Yingze Zhang,
Frank C. Sciurba,
Alison Morris
et al.
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Full-length article
(In Press Corrected Proof)
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19 December 2011 |
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Modulation of basophil activity: A novel function of the neuropeptide α-melanocyte–stimulating hormone
DOI: 10.1016/j.jaci.2011.11.012
Background: Little is known about the effect of neuropeptides on basophils, which are important effector cells in immune and allergic responses. Objective: This study aimed at revealing the role of α-...
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Markus Böhm,
Mara Apel,
Koji Sugawara,
Randolf Brehler,
Kerstin Jurk,
Thomas A. Luger,
Helmut Haas,
Ralf Paus,
Britta Eiz-Vesper,
Andrew F. Walls,
Evgeni Ponimaskin,
Manuela Gehring,
Alexander Kapp,
Ulrike Raap
et al.
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Full-length article
(In Press Corrected Proof)
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19 December 2011 |
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Home treatment of hereditary angioedema with icatibant administered by health care professionals
DOI: 10.1016/j.jaci.2011.10.039
Hereditary angioedema caused by C1-inhibitor deficiency (HAE-C1-INH) is a rare autosomal dominant disorder that manifests as recurrent unpredictable attacks of nonurticarial angioedema. Attacks are ty...
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Henriette Farkas,
Dorottya Csuka,
Zsuzsanna Zotter,
Lilian Varga,
Zoltán Böröcz,
György Temesszentandrási,
László Jakab,
István Karádi
et al.
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Short communication
(In Press Corrected Proof)
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12 December 2011 |
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Complete remission in 3 of 3 anti-IL-6–treated patients with Schnitzler syndrome
DOI: 10.1016/j.jaci.2011.10.031
Schnitzler syndrome (SchS) is a rare chronic inflammatory disease that usually occurs in patients older than 50 years and is characterized by urticarial rash and monoclonal gammopathy, usually of the ...
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Karoline Krause,
Eugen Feist,
Michael Fiene,
Tilmann Kallinich,
Marcus Maurer
et al.
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Short communication
(In Press Corrected Proof)
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12 December 2011 |
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Frequency of mold and pollen mixing in allergen immunotherapy prescriptions within a large health care system, 1990-2010
DOI: 10.1016/j.jaci.2011.10.027
Proteolytic enzymes can be found in extracts produced from insects, mites, and molds. Loss of allergen extract potency over time may be attributed to several factors including the activity of proteoly...
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Satyen Gada,
Bret Haymore,
Lorne McCoy,
Susan Kosisky,
Michael Nelson
et al.
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Short communication
(In Press Corrected Proof)
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12 December 2011 |
