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Cover 1
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Miscellaneous
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page OFC
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A Brief Overview of This Month's JACI
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Contents list
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pages 1A-2A
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Table of Contents
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Contents list
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pages 5A-14A
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Editorial Board
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Editorial board
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page 15A
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| Reader services |
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Information for Readers
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Miscellaneous
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page 16A
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Footnotes1
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News
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pages 18A-20A
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CME Activities Calendar
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Calendar
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pages 21A-22A
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| News beyond our pages |
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News Beyond Our Pages
Huber et al (J Immunol 2010, doi:10.4049/jimmunol.1000469) have delivered an unexpected finding: data supporting the possible use of IFN-α/β as a therapy for asthma and other atopic diseases. Contrary...
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Marc E. Rothenberg,
Jean Bousquet
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News
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pages 185-186
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| Reviews and feature articles |
| Clinical reviews in allergy and immunology |
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Long-term studies of the natural history of asthma in childhood
Segmentation of children with asthma and other wheezy disorders remains the main research challenge today, as it was when described 2 centuries ago. Early childhood wheezy disorders follow different t...
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Hans Bisgaard,
Klaus Bønnelykke
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Review article
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pages 187-197
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| Continuing Medical Education examination |
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Long-term studies of the natural history of asthma in childhood
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Examination
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pages 198-199
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| Mechanisms of allergic diseases |
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Using genetics to predict the natural history of asthma?
Clinical practice reminds us that there is considerable variability in the course of asthma over time. Treatment of patients with asthma would be considerably improved if one could accurately predict ...
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John W. Holloway,
Syed H. Arshad,
Stephen T. Holgate
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Review article
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pages 200-209
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| Continuing Medical Education examination |
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Using genetics to predict the natural history of asthma?
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Examination
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pages 210-211
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| Current perspectives |
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The Asthma Predictive Index: A very useful tool for predicting asthma in young children
12 July 2010
Recurrent wheezing is a common problem in young children: approximately 40% of children wheeze in their first year of life. However, only 30% of preschoolers with recurrent wheezing still have asthma ...
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Jose A. Castro-Rodriguez
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Full-length article
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pages 212-216
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| Rostrum |
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Potential mechanisms for the hypothesized link between sunshine, vitamin D, and food allergy in children
12 July 2010
Epidemiologic data suggest that the incidence of food allergy (FA) is increasing among children, yet a satisfactory model of its pathogenesis remains elusive. FA is the consequence of maladaptive immu...
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Milo F. Vassallo,
Carlos A. Camargo
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Full-length article
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pages 217-222
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| The Editors' choice |
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The Editors' Choice
As reported in this issue of the Journal, Simões et al (p 256) used protection by passively administered mAbs against respiratory syncytial virus (RSV) to separate the effects of RSV-induced lower res...
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Donald Y.M. Leung,
Stanley J. Szefler,
Associate Editors of the JACI
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Editorial
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pages 223-224
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| Asthma and lower airway disease |
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A cluster-randomized trial to provide clinicians inhaled corticosteroid adherence information for their patients with asthma
31 May 2010
Background: Inhaled corticosteroid (ICS) nonadherence is common among patients with asthma; however, interventions to improve adherence have often been complex and not easily applied to large patient ...
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L. Keoki Williams,
Edward L. Peterson,
Karen Wells,
Janis Campbell,
Mingqun Wang,
Vimal K. Chowdhry,
Matthew Walsh,
Robert Enberg,
David E. Lanfear,
Manel Pladevall
et al.
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Full-length article
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pages 225-231.e4
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Gene-environment interactions influence airways function in laboratory animal workers
25 June 2010
Background: Most diseases, including asthma, result from the interaction between environmental exposures and genetic variants. Functional variants of CD14 negatively affect lung function in farm worke...
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Karin A. Pacheco,
Cecile S. Rose,
Lori J. Silveira,
Michael V. Van Dyke,
Kelly Goelz,
Kristyn MacPhail,
Lisa A. Maier
et al.
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Full-length article
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pages 232-240
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Functional variants of the sphingosine-1-phosphate receptor 1 gene associate with asthma susceptibility
12 July 2010
Background: The genetic mechanisms underlying asthma remain unclear. Increased permeability of the microvasculature is a feature of asthma, and the sphingosine-1-phosphate receptor (S1PR1) is an essen...
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Xiaoguang Sun,
Shwu-Fan Ma,
Michael S. Wade,
Carlos Flores,
Maria Pino-Yanes,
Jaideep Moitra,
Carole Ober,
Rick Kittles,
Aliya N. Husain,
Jean G. Ford,
Joe G.N. Garcia
et al.
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Full-length article
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pages 241-249.e3
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Maternal dietary pattern during pregnancy is not associated with recurrent wheeze in children
28 June 2010
Background: The rise in asthma prevalence over the last few decades may be a result of changes in prenatal or early-life environment, including maternal diet during pregnancy. Previous studies have fo...
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Nancy E. Lange,
Sheryl L. Rifas-Shiman,
Carlos A. Camargo,
Diane R. Gold,
Matthew W. Gillman,
Augusto A. Litonjua
et al.
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Full-length article
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pages 250-255.e4
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The effect of respiratory syncytial virus on subsequent recurrent wheezing in atopic and nonatopic children
12 July 2010
Background: Although respiratory syncytial virus (RSV) lower respiratory tract infections (LRTIs) in early life are followed by later airway hyperreactivity, it is unclear whether there is a causal re...
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Eric A.F. Simões,
Xavier Carbonell-Estrany,
Christian H.L. Rieger,
Ian Mitchell,
Linda Fredrick,
Jessie R. Groothuis,
Palivizumab Long-Term Respiratory Outcomes Study Group
et al.
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Full-length article
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pages 256-262
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A randomized trial to test the effectiveness of art therapy for children with asthma
12 May 2010
Background: Art therapy has been used to help children cope with chronic illness but has not been specifically tested with children who have asthma. Objective: To test an art therapy intervention in a...
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Anya Beebe,
Erwin W. Gelfand,
Bruce Bender
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Full-length article
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pages 263-266.e1
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The Childhood Asthma Control Test∗: Retrospective determination and clinical validation of a cut point to identify children with very poorly controlled asthma
12 July 2010
Background: The Childhood Asthma Control Test (C-ACT) has demonstrated validity in classifying children aged 4 to 11 years as having either “well-controlled” or “not well-controlled” asthma. However, ...
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Andrew H. Liu,
Robert S. Zeiger,
Christine A. Sorkness,
Nancy K. Ostrom,
Bradley E. Chipps,
Kathleen Rosa,
Maria E. Watson,
Michael S. Kaplan,
John R. Meurer,
Todd A. Mahr,
Michael S. Blaiss,
Elisabeth Piault-Louis,
Jeffrey McDonald
et al.
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Full-length article
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pages 267-273.e1
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| Rhinitis, sinusitis, and upper airway disease |
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Indoor pet exposure and the outcomes of total IgE and sensitization at age 18 years
25 June 2010
Background: Early-life exposure to household pets has been shown to be protective against allergic sensitization in childhood. Objective: We sought to evaluate the association between early-life pet e...
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Ganesa Wegienka,
Christine Cole Johnson,
Suzanne Havstad,
Dennis R. Ownby,
Edward M. Zoratti
et al.
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Full-length article
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pages 274-279.e5
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| Atopic dermatitis and skin disease |
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Inducible costimulator (ICOS) is a marker for highly suppressive antigen-specific T cells sharing features of TH17/TH1 and regulatory T cells
12 July 2010
Background: CD4+CD25+ regulatory T (Treg) cells are involved in the downmodulation of numerous immune responses to pathogens, tumors, or allergens. Objective: In this study, we further characterized t...
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Marc Vocanson,
Aurore Rozieres,
Anca Hennino,
Gaelle Poyet,
Vincent Gaillard,
Sarah Renaudineau,
Amine Achachi,
Josette Benetiere,
Dominique Kaiserlian,
Bertrand Dubois,
Jean-François Nicolas
et al.
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Full-length article
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pages 280-289.e7
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Thymic stromal lymphopoietin–activated invariant natural killer T cells trigger an innate allergic immune response in atopic dermatitis
12 July 2010
Background: Although invariant natural killer T (iNKT) cells have been shown to play a critical role in the pathogenesis of asthma, the role of iNKT cells in atopic dermatitis (AD) has not been well e...
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Wen Hao Wu,
Chang Ook Park,
Sang Ho Oh,
Hee Jung Kim,
Yeon Sook Kwon,
Byung Gi Bae,
Ji Yeon Noh,
Kwang Hoon Lee
et al.
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Full-length article
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pages 290-299.e4
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Association between varicella zoster virus infection and atopic dermatitis in early and late childhood: A case-control study
12 July 2010
Background: Wild-type varicella zoster virus infection (WTVZV) early in childhood has been shown to protect against the development of asthma and atopy. Objective: To determine whether WTVZV in childh...
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Jonathan I. Silverberg,
Kevin B. Norowitz,
Edward Kleiman,
Nanette B. Silverberg,
Helen G. Durkin,
Rauno Joks,
Tamar A. Smith-Norowitz
et al.
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Full-length article
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pages 300-305
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| Food, drug, insect sting allergy, and anaphylaxis |
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Article Title |
Author(s) |
Type |
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Peanut-induced intestinal allergy is mediated through a mast cell–IgE–FcεRI–IL-13 pathway
12 July 2010
Background: Although implicated in the disease, the specific contributions of FcεRI and IL-13 to the pathogenesis of peanut-induced intestinal allergy are not well defined. Objectives: We sought to de...
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Meiqin Wang,
Katsuyuki Takeda,
Yoshiki Shiraishi,
Masakazu Okamoto,
Azzeddine Dakhama,
Anthony Joetham,
Erwin W. Gelfand
et al.
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Full-length article
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pages 306-316.e12
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Safe vaccination of patients with egg allergy with an adjuvanted pandemic H1N1 vaccine
25 June 2010
Background: Because influenza vaccine contains some residual egg protein, there is a theoretic risk of anaphylaxis when vaccinating patients with egg allergy. The objective of this study was to estima...
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Remi Gagnon,
Marie Noel Primeau,
Anne Des Roches,
Chantal Lemire,
Rhoda Kagan,
Stuart Carr,
Manale Ouakki,
Mélanie Benoît,
Gaston De Serres,
PHAC-CIHR Influenza Research Network (PCIRN)
et al.
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Full-length article
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pages 317-323
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A population-based questionnaire survey on the prevalence of peanut, tree nut, and shellfish allergy in 2 Asian populations
12 July 2010
Background: There has been a substantial increase in the prevalence of peanut and tree nut allergy in Western populations in the last 2 decades. However, there is an impression that peanut and tree nu...
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Lynette Pei-Chi Shek,
Elizabeth Ann Cabrera-Morales,
Shu E. Soh,
Irvin Gerez,
Pau Zhing Ng,
Fong Cheng Yi,
Stefan Ma,
Bee Wah Lee
et al.
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Full-length article
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pages 324-331.e7
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| Immune deficiencies, infection, and systemic immune disorders |
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Article Title |
Author(s) |
Type |
Pages |
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Impaired T-cell receptor activation in IL-1 receptor–associated kinase-4–deficient patients
12 July 2010
Background: IL-1 receptor–associated kinase 4 (IRAK-4) is an effector of the Toll-like receptor and IL-1 receptor pathways that plays a critical role in innate immune responses. The role of IRAK-4 in ...
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Douglas R. McDonald,
Frederick Goldman,
Oscar D. Gomez-Duarte,
Andrew C. Issekutz,
Dinakantha S. Kumararatne,
Rainer Doffinger,
Raif S. Geha
et al.
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Full-length article
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pages 332-337.e2
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| Mechanisms of allergy and clinical immunology |
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Article Title |
Author(s) |
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Gene-gene interaction in regulatory T–cell function in atopy and asthma development in childhood
05 July 2010
Background: Regulatory T–cell dysfunction is associated with development of the complex genetic conditions atopy and asthma. Therefore, we hypothesized that single nucleotide polymorphisms in genes in...
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Renske W.B. Bottema,
Marjan Kerkhof,
Naomi E. Reijmerink,
Carel Thijs,
Henriette A. Smit,
Constant P. van Schayck,
Bert Brunekreef,
Antoon J. van Oosterhout,
Dirkje S. Postma,
Gerard H. Koppelman
et al.
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Full-length article
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pages 338-346.e10
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Expression of IL-4 receptor α on smooth muscle cells is not necessary for development of experimental allergic asthma
25 June 2010
Background: Airflow in the lungs of patients with allergic asthma is impaired by excessive mucus production and airway smooth muscle contractions. Elevated levels of the cytokines IL-4 and IL-13 are a...
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Frank Kirstein,
William G.C. Horsnell,
Douglas A. Kuperman,
Xiaozhu Huang,
David J. Erle,
Andreas L. Lopata,
Frank Brombacher
et al.
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Full-length article
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pages 347-354
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The leukocyte activation antigen CD69 limits allergic asthma and skin contact hypersensitivity
12 July 2010
Background: Allergic diseases have a major health care impact in industrialized countries. The development of these diseases is influenced by exposure to allergen and to immunological and genetic fact...
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Pilar Martín,
Manuel Gómez,
Amalia Lamana,
Adela Matesanz Marín,
José R. Cortés,
Marta Ramírez-Huesca,
Olga Barreiro,
Pedro López-Romero,
Cristina Gutiérrez-Vázquez,
Hortensia de la Fuente,
Aránzazu Cruz-Adalia,
Francisco Sánchez-Madrid
et al.
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Full-length article
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pages 355-365.e3
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IL-13 and TH2 cytokine exposure triggers matrix metalloproteinase 7–mediated Fas ligand cleavage from bronchial epithelial cells
12 July 2010
Background: Bronchial epithelial damage and activation likely contribute to the inflammatory and airway-remodeling events characteristic of severe asthma. Interaction of Fas receptor (CD95) with its l...
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Samuel J. Wadsworth,
Ryo Atsuta,
J. Oliver McIntyre,
Tillie-Louise Hackett,
Gurpreet K. Singhera,
Delbert R. Dorscheid
et al.
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Full-length article
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pages 366-374.e8
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Mechanisms of allergen-specific desensitization
12 July 2010
Background: Allergen-specific desensitization (SIT) is the most effective therapy for allergies. Although allergen-specific antibodies have an important role in the process, mechanisms of IgG-mediated...
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Christina Uermösi,
Roger R. Beerli,
Monika Bauer,
Vania Manolova,
Klaus Dietmeier,
Regula B. Buser,
Thomas M. Kündig,
Philippe Saudan,
Martin F. Bachmann
et al.
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Full-length article
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pages 375-383
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| Letters to the Editor |
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Article Title |
Author(s) |
Type |
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Food allergen advisory labeling and product contamination with egg, milk, and peanut
12 July 2010
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Lara S. Ford,
Steve L. Taylor,
Robert Pacenza,
Lynn M. Niemann,
Debra M. Lambrecht,
Scott H. Sicherer
et al.
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Correspondence
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pages 384-385
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Trends in pediatric emergency department visits for food-induced anaphylaxis
12 July 2010
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Susan A. Rudders,
Aleena Banerji,
Milo F. Vassallo,
Sunday Clark,
Carlos A. Camargo
et al.
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Correspondence
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pages 385-388
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Eight-year outcomes of the Childhood Asthma Prevention Study
21 June 2010
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Brett G. Toelle,
Kitty K.W. Ng,
Daniele Crisafulli,
Elena G. Belousova,
Catarina Almqvist,
Karen Webb,
Euan R. Tovey,
Andrew S. Kemp,
Craig M. Mellis,
Stephen R. Leeder,
Guy B. Marks,
Childhood Asthma Prevention Team
et al.
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Correspondence
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pages 388-389.e3
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Risk of cataracts in the Childhood Asthma Management Program Cohort
12 July 2010
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Hengameh H. Raissy,
Alice L. Sternberg,
Paul Williams,
Aaron Jacobs,
H. William Kelly,
CAMP Research Group
et al.
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Correspondence
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pages 389-392.e4
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Successful long-term immunologic reconstitution by allogeneic hematopoietic stem cell transplantation cures patients with autosomal dominant hyper-IgE syndrome
28 June 2010
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Evgenios Goussetis,
Ioulia Peristeri,
Vasiliki Kitra,
Joanne Traeger-Synodinos,
Maria Theodosaki,
Katerina Psarra,
Maria Kanariou,
Fotini Tzortzatou-Stathopoulou,
Eftichia Petrakou,
Irene Fylaktou,
Emmanuel Kanavakis,
Stelios Graphakos
et al.
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Correspondence
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pages 392-394
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Biological agents: New drugs, old problems
25 June 2010
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Rosa Muñoz-Cano,
Jerónimo Carnés,
Jaime Sanchez-Lopez,
Albert Saiz,
Joan Bartra,
M. Angeles Lopez-Matas,
Cesar Picado,
Antonio Valero
et al.
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Correspondence
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pages 394-395
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Infants aged 12 months can mount adequate serotype-specific IgG responses to pneumococcal polysaccharide vaccine
28 June 2010
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Anne Balloch,
Paul V. Licciardi,
Fiona M. Russell,
Edward K. Mulholland,
Mimi L.K. Tang
et al.
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Correspondence
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pages 395-397
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Regulation and characterization of IL-17A expression in patients with chronic rhinosinusitis and its relationship with eosinophilic inflammation
12 July 2010
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Seiichiro Makihara,
Mitsuhiro Okano,
Tazuko Fujiwara,
Shin Kariya,
Yohei Noda,
Takaya Higaki,
Kazunori Nishizaki
et al.
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Correspondence
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pages 397-400.e11
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Topical application of dehydroxymethylepoxyquinomicin improves allergic inflammation via NF-κB inhibition
12 July 2010
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Asuka Hamasaka,
Naoya Yoshioka,
Riichiro Abe,
Satoshi Kishino,
Kazuo Umezawa,
Michitaka Ozaki,
Satoru Todo,
Hiroshi Shimizu
et al.
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Correspondence
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pages 400-403
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A novel non–IgE-mediated pathway of mite-induced inflammation
12 July 2010
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Mario Sánchez-Borges,
Arnaldo Capriles-Hulett,
Fernan Caballero-Fonseca
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Correspondence
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pages 403-404
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Nitric oxide in exhaled breath is poorly correlated to sputum eosinophils in patients with prednisone-dependent asthma
12 July 2010
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Parameswaran Nair,
Melanie Kjarsgaard,
Susan Armstrong,
Ann Efthimiadis,
Paul M. O'Byrne,
Frederick E. Hargreave
et al.
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Correspondence
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pages 404-406
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Comparison of the allergic and nonallergic CD4+ T-cell responses to the major dog allergen Can f 1
12 July 2010
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Suvi Parviainen,
Antti Taivainen,
Aino Liukko,
Anssi Nieminen,
Marja Rytkönen-Nissinen,
Tuure Kinnunen,
Tuomas Virtanen
et al.
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Correspondence
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pages 406-408.e4
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Fluctuation of blood and skin plasmacytoid dendritic cells in drug-induced hypersensitivity syndrome
12 July 2010
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Kazunari Sugita,
Mikiko Tohyama,
Hideaki Watanabe,
Atsushi Otsuka,
Saeko Nakajima,
Masafumi Iijima,
Koji Hashimoto,
Yoshiki Tokura,
Yoshiki Miyachi,
Kenji Kabashima
et al.
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Correspondence
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pages 408-410
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Man's best friend? The effect of pet ownership on house dust microbial communities
15 July 2010
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Kei E. Fujimura,
Christine C. Johnson,
Dennis R. Ownby,
Michael J. Cox,
Eoin L. Brodie,
Suzanne L. Havstad,
Edward M. Zoratti,
Kimberley J. Woodcroft,
Kevin R. Bobbitt,
Ganesa Wegienka,
Homer A. Boushey,
Susan V. Lynch
et al.
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Correspondence
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pages 410-412.e3
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| Correspondence |
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Article Title |
Author(s) |
Type |
Pages |
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Reduced vitamin D levels in adult subjects with chronic urticaria
12 July 2010
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Warren Ancheta Thorp,
Whitney Goldner,
Jane Meza,
Jill A. Poole
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Correspondence
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page 413
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Reply
12 July 2010
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Tissa Hata,
Richard Gallo
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Correspondence
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pages 413-414
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Potent topical steroids are one of the treatments for cutaneous T-cell lymphoma
12 July 2010
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Pablo Fernandez-Peñas
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Correspondence
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page 414
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Reply
12 July 2010
|
Felix M. Arellano,
Alejandro Arana,
Charles E. Wentworth,
Eulogio Conde
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Correspondence
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pages 414-415
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Successful treatment of idiopathic anaphylaxis in an adolescent
12 July 2010
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Tracy J. Pitt,
Nestor Cisneros,
Chrystyna Kalicinsky,
Allan B. Becker
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Correspondence
|
pages 415-416
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Reply
12 July 2010
|
Melody C. Carter
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Correspondence
|
page 416
|
| Clinical pearls |
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Article Title |
Author(s) |
Type |
Pages |
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Identifying and managing the infant and toddler at risk for asthma
12 July 2010
Recurrent wheezing is a common problem, with approximately 50% of children experiencing wheeze in the first year of life, resulting in a substantial effect on the children, their families, and the hea...
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Theresa W. Guilbert
|
Editorial
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pages 417-422
|
