Investigation of the mechanism of alcohol-induced bronchial asthma☆☆☆★

Abstract 

BACKGROUND: Many Japanese patients with asthma experience episodes or exacerbation of asthma after alcohol consumption. This phenomenon is not seen in Caucasians and is specific to Asians. This has been thought to be attributable to a difference in alcohol metabolism, in particular the metabolism of acetaldehyde, between Asians and Caucasians. METHODS: An oral ethanol challenge test, a leukocyte histamine release test, and an ELISA for detection of IgE specific to acetaldehyde–human serum albumin conjugate were carried out in 42 adults with bronchial asthma and nine healthy adults.> RESULTS: Fifty-five percent of the patients with asthma responded to the ethanol challenge and showed a 20% or greater reduction in forced expiratory volume in 1 second. Blood acetaldehyde and plasma histamine levels were significantly higher in responders than in nonresponders. The leukocyte histamine release test revealed no ethanol-induced histamine release. Acetaldehyde, on the other hand, was found to induce histamine release in a volume-dependent manner. The histamine release was significantly higher in the asthma group (both responders and nonresponders) than in the healthy control group. ELISA did not detect any IgE specific to acetaldehyde–human serum albumin conjugate. CONCLUSION: Alcohol-induced bronchial asthma seems to develop as follows. Alcohol elevates blood acetaldehyde levels, which leads to degranulation of mast cells (or basophils). The resultant release of chemical mediators, such as histamine, induces asthma. (J ALLERGY CLIN IMMUNOL 1996;97:74-84.)

Keywords:  Bronchial asthma, alcohol, Asians, Caucasians, histamine release, acetaldehyde

Abbreviations:  ALDH: , Aldehyde dehydrogenase, DSCG: , Disodium cromoglycate, FBS: , Fetal bovine serum, FEV₁: , Forced expiratory volume in 1 second, HSA: , Human serum albumin, PBS: , Phosphate-buffered saline