The Journal of Allergy and Clinical Immunology
Volume 97, Issue 1 , Pages 53-64 , January 1996

Single amino acid substitutions on a Japanese cedar pollen allergen (Cry j 1)-derived peptide induced alterations in human T cell responses and T cell receptor antagonism

Received 1 November 1994 ,Revised 14 March 1995 ,Accepted 17 March 1995.

References 

  1. Sloan-Lancaster J, Evavold BD, Allen PM. Induction of T-cell anergy by altered T-cell-recepter ligand on live antigen-presenting cells. Nature. 1993;363:156–159
  2. De Magistris MT, Alexander J, Coggeshall M, et al.  Antigen analog-major histocompatibility complexes act as antagonists of the T cell receptor. Cell. 1992;68:625–634
  3. Racioppi L, Ronchese F, Matis LA, Germain RN. Peptide-major histocompatibility complexes with mixed agonist/ antagonist properties provide evidence for ligand-related differences in T cell receptor-dependent intracellular signaling. J Exp Med. 1993;177:1047–1060
  4. Evavold BD, Allen PM. Separation of IL-4 production from Th cell proliferation by an altered T cell receptor ligand. Science. 1991;252:1308–1310
  5. Soloway P, Fish S, Passmore H, Gefter M, Coffee R, Manser T. Regulation of the immune response to peptide antigens: differential induction of immediate-type hypersensitivity and T cell proliferation due to changes in either peptide structure or major histocompatibility complex haplotype. J Exp Med. 1991;174:847–858
  6. Evavold BD, Sloan-Lancaster J, Hsu BL, Allen PM. Separation of helper 1 clone cytolysis from proliferation and lymphokine production using analog peptides. J Immunol. 1993;150:3131–3140
  7. Stern LJ, Brown JH, Jardetzky TS, et al.  Crystal structure of the human class II MHC protein HLA-DR1 complexed with an influenza virus peptide. Nature. 1994;368:215–221
  8. Yssel H, Johnson KE, Schneider PV, et al.  T cell activation-inducing epitopes of the house dust mite allergen Der p I. Proliferation and lymphokine production patterns by Der p I-specific CD4+T cell clones. J Immunol. 1992;148:738–745
  9. Ebner C, Szépfalusi Z, Ferreira F, et al.  Identification of multiple T cell epitopes on Bet v I, the major birch pollen allergen, using specific T cell clones and overlapping peptides. J Immunol. 1993;150:1047–1054
  10. van Neerven RJJ, van t’Hof W, Ringrose JH, et al.  T cell epitopes of house dust mite major allergen Der p II. J Immunol. 1993;151:2326–2335
  11. van Neerven RJJ, van de Pol MM, van Milligan FJ, Jansen HM, Aalberse RC, Kapsenberg ML. Characterization of cat dander-specific T lymphocytes from atopic patients. J Immunol. 1994;152:4203–4210
  12. Spiegelberg HL, Beck L, Stevenson DD, Ishioka GY. Recognition of T cell epitopes and lymphokine secretion by rye grass allergen Lolium perenne I-specific human T cell clones. J Immunol. 1994;152:4706–4711
  13. Yasueda H, Yui Y, Shimizu T, Shida T. Isolation and partial characterization of major allergen from Japanese cedar (Cryptomeria japonica) pollen. J Allergy Clin Immunol. 1983;71:77–86
  14. Matsushita S, Muto M, Suemura M, Saito Y, Sasazuki T. HLA-linked nonresponsiveness to Cryptomeria japonica pollen antigen. Nonresponsiveness is mediated by antigen-specific suppressor T cell. J Immunol. 1987;138:109–115
  15. Griffith IJ, Lussier A, Garman R, Koury R, Yeung H, Polloch J. cDNA cloning of Cry j I, the major allergen of Cryptomeria japonica (Japanese cedar) [Abstract]. J Allergy Clin Immunol. 1993;91:339
  16. Sone T, Komiyama N, Shimizu K, Kusakabe T, Morikubo K, Kino K. Cloning and sequencing of cDNA coding for Cry j I, a major allergen of Japanese cedar pollen. Biochem Bioph Res Co. 1994;199:619–625
  17. Sone T, Tsukamoto K, Hirayama K, et al.  Two distinct class II molecules encoded by the genes within the HLA-DR subregion of HLA-Dw2 and Dw12 can act as stimulating and restriction molecules. J Immunol. 1985;135:1288–1298
  18. Hirayama K, Nishimura Y, Tsukamoto K, Sasazuki T. Functional and molecular analysis of three distinct HLA-DR4 β-chains responsible for the MLR between HLA-Dw4, Dw15, and DKT2. J Immunol. 1986;137:924–933
  19. Kasahara M, Takenouchi T, Ikeda H, et al.  Serologic dissection of HLA-D specificities by the use of monoclonal antibodies U. distinction between HLA-Dw2 and HLA-Dw12. Immunogenetics. 1983;18:525–536
  20. Kasahara M, Takenouchi T, Ogasawara K, et al.  Serologic dissection of HLA-D specificities by the use of monoclonal antibodies. Immunogenetics. 1983;17:485–495
  21. Ishikawa N, Kojima H, Nakayama T, et al.  Detection of a novel HLA-DQ specificity: serological and immunochemical analyses by a monoclonal antibody. Immunogenetics. 1987;26:143–149
  22. Schamboeck A, Korman AJ, Kamb A, Strominger J. Organization of the transcriptional unit of a human class II histocompatibility antigen: HLA-DR heavy chain. Nucl Acids Res. 1983;11:8663–8675
  23. Kamikawaji N, Fujisawa K, Yoshizumi H, et al.  HLA-DQ-restricted CD4+T cells specific to streptococcal antigen present in low but not in high responders. J Immunol. 1991;146:2560–2567
  24. Nishimura Y, Thorsby E, Ronningen KJ, et al.  General organization and overview of the disease component. In:  Tsuji K,  Aizawa M,  Sasazuki T editor. HLA 1991. London: Oxford University Press; 1992;p. 693–700
  25. Fukui Y, Nishimura Y, Iwanaga T, et al.  Analysis of glycosuria and insulitis in NOD mice expressing HLA-DQw6 molecule. J Immunogenet. 1990;16:445–453
  26. Bodner JG, Marsh SGE, Albert ED, et al.  Nomenclature for factors of the HLA system, 1994. Hum Immunol. 1994;41:1–20
  27. Matsushita S, Takahashi K, Motoki M, Komoriya K, Ikagawa S, Nishimura Y. Allele specificity of structural requirement for peptides bound to HLA-DRB1*0405 and -DRB1*0406 complexes: implication for the HLA-associated susceptibility to methimazole-induced insulin autoimmune syndrome. J Exp Med. 1994;180:873–883
  28. Hammer J, Valsasnini P, Tolba K, et al.  Promiscuous and allele-specific anchors in HLA-DR-binding peptides. Cell. 1993;74:197–203
  29. Wierenga EA, Snoek M, Bos JD, Jansen HM, Kapsenberg ML. Comparison of diversity and function of house dust mite-specific T lymphocyte clones from atopic and non-atopic donors. Eur J Immunol. 1990;20:1519–1526
  30. Parronchi P, Macchia D, Piccinni M-P, et al.  Allergen- and bacterial antigen-specific T-cell clones established from atopic donors show a different profile of cytokine production. Proc Natl Acad Sci U S A. 1991;88:4538–4542
  31. Gajewski TF, Schell SR, Fitch FW. Evidence implicating utilization of different T cell receptor-associated signaling pathways by Th1 and Th2 clones. J Immunol. 1990;144:4110–4120
  32. Sloan-Lancaster J, Shaw AS, Rothbard JB, Allen PM. Partial T cell signaling: altered phospho-ζ and lack of Zap70 recruitment in APL-induced T cell anergy. Cell. 1994;79:913–922
  33. Madrenas J, Wange RL, Wang JL, Isakov N, Samelson LE, Germain RN. ζ phosphorylation without ZAP-70 activation induced by TCR antagonists or partial agonists. Science. 1995;267:515–518
  34. Seder RA, Paul WE. Acquisition of lymphokine-producing phonotype by CD4+ T cells. Annu Rev Immunol. 1994;12:635–673
  35. Brown JH, Jardetzky TS, Gorga JC, et al.  Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1. Nature. 1993;364:33–39
  36. Betz M, Fox BS. Prostaglandin E2 inhibits production of Th1 lymphokines but not of Th2 lymphokines. J Immunol. 1991;146:108–113
  37. Chan SC, Kim J-W, Henderson WR, Hanifin JM. Altered prostaglandin E2 regulation of cytokine production in atopic dermatitis. J Immunol. 1993;151:3345–3352
  38. Briner TJ, Kuo M-c, Keating KM, Rogers BL, Greenstein JL. Peripheral T-cell tolerance induced in naive and primed mice by subcutaneous injection of peptides from the major cat allergen Fel d I. Proc Natl Acad Sci U S A. 1993;90:7608–7612
  39. Hoyne GF, O’Hehir RE, Wraith DC, Thomas WR, Lamb JR. Inhibition of T cell and antibody responses to house dust mite allergen by inhalation of the dominant T cell epitope in naive and sensitized mice. J Exp Med. 1993;178:1783–1788

☆ From athe Division of Immunogenetics, Department of Neuroscience and Immunology, Kumamoto University Graduate School of Medical Sciences; and bthe Department of Otorhinolaryngology, Kumamoto University School of Medicine.

☆☆ Supported in part by Grants-in-Aid 03452276, 05278118, 05272105, and 05272104 from the Ministry of Education, Science and Culture, Japan, Research Grant for Intractable Diseases from the Ministry of Health and Welfare, Japan, Ichiro Kanehara Foundation, Terumo Life Science Foundation, Kato Memorial Foundation, Japan Rheumatism Foundation, Meiji Institute of Health Science, Hokuriku Pharmaceutical Co. for Research of Allergy, and Mochida Memorial Foundation.

★ Reprint requests: Yasuharu Nishimura, MD, Division of Immunogenetics, Department of Neuroscience and Immunology, Kumamoto University Graduate School of Medical Sciences, Honjo 2-2-1, Kumamoto 860, Japan.

★★ 0091-6749/96 $5.00 + 0 1/1/64980

PII: S0091-6749(96)70283-X

The Journal of Allergy and Clinical Immunology
Volume 97, Issue 1 , Pages 53-64 , January 1996

Article Tools

* Image Usage & Resolution