The Journal of Allergy and Clinical Immunology
Volume 126, Issue 1 , Pages 28-30 , July 2010

Intelligent granules: Are eosinophil crystalloid granules inimitable?

  • Salahaddin Mahmudi-Azer, MD, PhD

      Affiliations

    • Department of Medicine, the University of Calgary, Calgary, Alberta
    • ,
  • S.O. (Wole) Odemuyiwa, DVM, PhD

      Affiliations

    • Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada
    • ,
  • Redwan Moqbel, PhD, FRCPath

      Affiliations

    • Department of Immunology, University of Manitoba, Winnipeg, Manitoba, Canada
    • Corresponding Author InformationAddress for reprints: Redwan Moqbel, PhD, FRCPath, Department of Immunology, 471 Apotex Centre, 750 McDermot Ave, Winnipeg, Manitoba R3E 0T5, Canada.

Received 24 March 2010 ,Revised 14 April 2010 ,Accepted 14 April 2010.

References 

  1. Haldar P, Brightling CE, Hargadon B, Gupta S, Monteiro W, Sousa A, et al. Mepolizumab and exacerbations of refractory eosinophilic asthma. N Engl J Med. 2009;360:973–984
  2. Nair P, Pizzichini MM, Kjarsgaard M, Inman MD, Efthimiadis A, Pizzichini E, et al. Mepolizumab for prednisone-dependent asthma with sputum eosinophilia. N Engl J Med. 2009;360:985–993
  3. Flood-Page P, Menzies-Gow A, Phipps S, Ying S, Wangoo A, Ludwig MS, et al. Anti-IL-5 treatment reduces deposition of ECM proteins in the bronchial subepithelial basement membrane of mild atopic asthmatics. J Clin Invest. 2003;112:1029–1036
  4. Moqbel R, Lacy P. New concepts in effector functions of eosinophil cytokines. Clin Exp Allergy. 2000;30:1667–1671
  5. Adamko D, Lacy P, Moqbel R. Eosinophil function in allergic inflammation: from bone marrow to tissue response. Curr Allergy Asthma Rep. 2004;4:149–158
  6. Mahmudi-Azer S, Velazquez JR, Lacy P, Denburg JA, Moqbel R. Immunofluorescence analysis of cytokine and granule protein expression during eosinophil maturation from cord blood-derived CD34 progenitors. J Allergy Clin Immunol. 2000;105:1178–1184
  7. Neves JS, Perez SA, Spencer LA, Melo RC, Reynolds L, Ghiran I, et al. Eosinophil granules function extracellularly as receptor-mediated secretory organelles. Proc Natl Acad Sci U S A. 2008;105:18478–18483
  8. Neves JS, Radke AL, Weller PF. Cysteinyl leukotrienes acting via granule membrane-expressed receptors elicit secretion from within cell-free human eosinophil granules. J Allergy Clin Immunol. 2010;125:477–482
  9. Scepek S, Moqbel R, Lindau M. Compound exocytosis and cumulative degranulation by eosinophils and their role in parasite killing. Parasitol Today. 1994;10:276–278
  10. Lacy P, Mahmudi-Azer S, Bablitz B, Hagen SC, Velazquez JR, Man SF, et al. Rapid mobilization of intracellularly stored RANTES in response to interferon-gamma in human eosinophils. Blood. 1999;94:23–32
  11. Melo RC, Perez SA, Spencer LA, Dvorak AM, Weller PF. Intragranular vesiculotubular compartments are involved in piecemeal degranulation by activated human eosinophils. Traffic. 2005;6:866–879
  12. Moqbel R, Coughlin JJ. Differential secretion of cytokines. Sci STKE. 2006;2006:pe26
  13. Erjefalt JS, Andersson M, Greiff L, Korsgren M, Gizycki M, Jeffery PK, et al. Cytolysis and piecemeal degranulation as distinct modes of activation of airway mucosal eosinophils. J Allergy Clin Immunol. 1998;102:286–294
  14. Erjefalt JS, Greiff L, Andersson M, Matsson E, Petersen H, Linden M, et al. Allergen-induced eosinophil cytolysis is a primary mechanism for granule protein release in human upper airways. Am J Respir Crit Care Med. 1999;160:304–312
  15. Tulic MK, Sly PD, Andrews D, Crook M, Davoine F, Odemuyiwa SO, et al. Thymic indoleamine 2,3-dioxygenase-positive eosinophils in young children: potential role in maturation of the naive immune system. Am J Pathol. 2009;175:2043–2052

 Disclosure of potential conflict of interest: The authors have declared that they have no conflict of interest.

PII: S0091-6749(10)00656-1

doi: 10.1016/j.jaci.2010.04.008

The Journal of Allergy and Clinical Immunology
Volume 126, Issue 1 , Pages 28-30 , July 2010

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