The Editors' Choice

Primary end points: relative differences between treatment groups and corresponding P values.

Pattern of component recognition between subjects with peanut allergy (yellow) and peanut-tolerant subjects (green). Ara h 2 offers best discrimination.

Plasticity of T_H17 cells. Human T_H17 cells, which express retinoic acid receptor–related orphan receptor C (RORC), T-box transcription factor (T-bet), IL-12Rβ2, IL-4Rα, CD161, and CCR6 in the presence of IL-12 produced by dendritic cells, exhibit upregulation of T-bet expression, acquire CXCR3 on their surface, and shift to the production of IFN-γ (T_H17/T_H1 and T_H1 cells), as has recently been shown even in mice. In the presence of IL-4, which can be produced by T_H2 cells, basophils, and mast cells, human T_H17 cells upregulate GATA-3 and shift to the production of IL-4 (T_H17/T_H2 cells).

Copriming moDCs from a subject with cat allergy with H22–Fel d 1 and TSLP provides a potent T_H2 stimulus compared with priming with non–receptor-targeted Fel d 1 (Fel), H22–Fel d 1 (H-Fel), or TSLP alone.

FOXP 3 expression in the thymus and lymph nodes of patients with OS.