« Previous
Next »
The Journal of Allergy and Clinical Immunology
Volume 125, Issue 3
, Pages 711-718.e2
, March 2010
Naturally processed T cell–activating peptides of the major birch pollen allergen
References
- Immune responses in healthy and allergic individuals are characterized by a fine balance between allergen-specific T regulatory 1 and T helper 2 cells. J Exp Med. 2004;199:1567–1575
- Long-lived Th2 clones specific for seasonal and perennial allergens can be detected in blood and skin by their TCR-hypervariable regions. J Immunol. 1998;160:2022–2027
- . Several distinct properties of the IgE repertoire determine effector cell degranulation in response to allergen challenge. J Allergy Clin Immunol. 2008;122:298–304
- . Immunoglobulin E-independent major histocompatibility complex-restricted T cell peptide epitope-induced late asthmatic reactions. J Exp Med. 1999;189:1885–1894
- Cooking birch pollen-related food: divergent consequences for IgE- and T cell-mediated reactivity in vitro and in vivo. J Allergy Clin Immunol. 2006;118:242–249
- . MHC-dependent antigen processing and peptide presentation: providing ligands for T lymphocyte activation. Cell. 1994;76:287–299
- . Dendritic cells: translating innate to adaptive immunity. Curr Top Microbiol Immunol. 2006;311:17–58
- . Phagocytosis and antigen presentation in dendritic cells. Immunol Rev. 2007;219:143–156
- The high affinity IgE receptor (Fc epsilon RI) mediates IgE-dependent allergen presentation. J Immunol. 1995;154:6285–6290
- Fc epsilon receptor I on dendritic cells delivers IgE-bound multivalent antigens into a cathepsin S-dependent pathway of MHC class II presentation. J Immunol. 1998;161:2731–2739
- . Evidence for a differential expression of the FcepsilonRIgamma chain in dendritic cells of atopic and nonatopic donors. J Clin Invest. 2003;111:1047–1056
- . T-cell epitopes of food allergens. Clin Rev Allergy Immunol. 2006;30:97–108
- . T-cell responses to allergens. J Allergy Clin Immunol. 2007;119:280–294quiz 95-96
- Predominant naturally processed peptides bound to HLA-DR1 are derived from MHC-related molecules and are heterogeneous in size. Nature. 1992;358:764–768
- Analysis of MHC class II antigen processing by quantitation of peptides that constitute nested sets. J Immunol. 2002;169:5089–5097
- . Analysis of allele-specific contact sites of natural HLA-DR17 ligands. J Immunol. 1994;153:1141–1149
- . Amino acid residues that flank core peptide epitopes and the extracellular domains of CD4 modulate differential signaling through the T cell receptor. J Exp Med. 1994;179:1945–1956
- . T cell receptor recognition of MHC class II-bound peptide flanking residues enhances immunogenicity and results in altered TCR V region usage. Immunity. 1997;7:387–399
- . Modulation of the immunogenicity of antigenic determinants by their flanking residues. Immunol Today. 1998;19:217–220
- Dissection of immunoglobulin E and T lymphocyte reactivity of isoforms of the major birch pollen allergen Bet v 1: potential use of hypoallergenic isoforms for immunotherapy. J Exp Med. 1996;183:599–609
- Modulation of IgE reactivity of allergens by site-directed mutagenesis: potential use of hypoallergenic variants for immunotherapy. FASEB J. 1998;12:231–242
- Identification of multiple T cell epitopes on Bet v I, the major birch pollen allergen, using specific T cell clones and overlapping peptides. J Immunol. 1993;150:1047–1054
- Bet v 1142-156 is the dominant T-cell epitope of the major birch pollen allergen and important for cross-reactivity with Bet v 1-related food allergens. J Allergy Clin Immunol. 2005;116:213–219
- . Identification of a highly promiscuous and an HLA allele-specific T-cell epitope in the birch major allergen Bet v 1: HLA restriction, epitope mapping and TCR sequence comparisons. Clin Exp Allergy. 1999;29:478–487
- Diversity of TCRAV and TCRBV sequences used by human T-cell clones specific for a minimal epitope of Bet v 1, the major birch pollen allergen. Immunogenetics. 1995;42:53–58
- Assessment of Bet v 1-specific CD49 + T cell responses in allergic and nonallergic individuals using MHC class II peptide tetramers. J Immunol. 2008;180:4514–4522
- Antigen presentation of the immunodominant T-cell epitope of the major mugwort pollen allergen, Art v 1, is associated with the expression of HLA-DRB1 ∗01. J Allergy Clin Immunol. 2005;115:399–404
- A novel approach to specific allergy treatment: the recombinant allergen-S-layer fusion protein rSbsC-Bet v 1 matures dendritic cells that prime Th0/Th1 and IL-10-producing regulatory T cells. J Immunol. 2007;179:7270–7275
- . Differential lysosomal proteolysis in antigen-presenting cells determines antigen fate. Science. 2005;307:1630–1634
- A novel strategy for the discovery of MHC class II-restricted tumor antigens: identification of a melanotransferrin helper T-cell epitope. Cancer Res. 2005;65:10068–10078
- . Chemistry of peptides associated with MHC class I and class II molecules. Curr Opin Immunol. 1995;7:85–96
- . Proteolytic sensitivity and helper T-cell epitope immunodominance associated with the mobile loop in Hsp10s. J Biol Chem. 2002;277:155–160
- . Enhancing immunogenicity by limiting susceptibility to lysosomal proteolysis. J Exp Med. 2006;203:2049–2055
- Nonallergic individuals recognize the same T cell epitopes of Bet v 1, the major birch pollen allergen, as atopic patients. J Immunol. 1995;154:1932–1940
- . Kinetics of dendritic cell activation: impact on priming of TH1, TH2 and nonpolarized T cells. Nat Immunol. 2000;1:311–316
Supported by P10150 of the Österreichische Nationalbank, the Christian Doppler Laboratory for Allergy Diagnosis and Therapy, and the Christian Doppler Laboratory for Immunomodulation, Austria.
Disclosure of potential conflict of interest: F. Ferreira has received research support from Biomay AG, the Austrian Science Fund, the Christian Doppler Research Association, and the Austrian National Bank and has provided legal consultation services or expert witness testimony relevant to Indoor Biotechnologies and AllergenOnline Database. B. Bohle has received research support from the Austrian Science Fund and the Christian Doppler Laboratory. The rest of the authors have declared that they have no conflict of interest.
PII: S0091-6749(09)01629-7
doi: 10.1016/j.jaci.2009.10.052
© 2010 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.
« Previous
Next »
The Journal of Allergy and Clinical Immunology
Volume 125, Issue 3
, Pages 711-718.e2
, March 2010
