The Journal of Allergy and Clinical Immunology
Volume 124, Issue 6 , Pages 1360-1362 , December 2009

Increased IFN-γ activity in seasonal allergic rhinitis is decreased by corticosteroid treatment

  • Hui Wang, MM

      Affiliations

    • Unit for Clinical Systems Biology, Queen Silvia Children's Hospital, University of Gothenburg, Gothenburg, Sweden
    • These authors contributed equally to this work.
    • ,
  • Fredrik Barrenäs, MS

      Affiliations

    • Unit for Clinical Systems Biology, Queen Silvia Children's Hospital, University of Gothenburg, Gothenburg, Sweden
    • These authors contributed equally to this work.
    • ,
  • Sören Bruhn, PhD

      Affiliations

    • Unit for Clinical Systems Biology, Queen Silvia Children's Hospital, University of Gothenburg, Gothenburg, Sweden
    • ,
  • Reza Mobini, PhD

      Affiliations

    • Unit for Clinical Systems Biology, Queen Silvia Children's Hospital, University of Gothenburg, Gothenburg, Sweden
    • ,
  • Mikael Benson, MD, PhD

      Affiliations

    • Unit for Clinical Systems Biology, Queen Silvia Children's Hospital, University of Gothenburg, Gothenburg, Sweden
    • Pediatric Allergy Unit, Queen Silvia Children's Hospital, Gothenburg, Sweden

References 

  1. Pernis A, Gupta S, Gollob KJ, Garfein E, Coffman RL, Schindler C, et al. Lack of interferon gamma receptor beta chain and the prevention of interferon gamma signaling in TH1 cells. Science. 1995;269:245–247
  2. Woodfolk JA. T-cell responses to allergens. J Allergy Clin Immunol. 2007;119:280–294
  3. Benson M, Strannegård IL, Strannegård O, Wennergren G. Topical steroid treatment of allergic rhinitis decreases nasal fluid TH2 cytokines, eosinophils, eosinophil cationic protein, and IgE but has no significant effect on IFN-gamma, IL-1beta, TNF-alpha, or neutrophils. J Allergy Clin Immunol. 2000;106:307–312
  4. Benson M, Langston MA, Adner M, Andersson B, Torinssson-Naluai A, Cardell LO. A network-based analysis of the late-phase reaction of the skin. J Allergy Clin Immunol. 2006;118:220–225
  5. Cho SH, Stanciu LA, Holgate ST, Johnston SL. Increased interleukin-4, interleukin-5, and interferon-gamma in airway CD4+ and CD8 + T cells in atopic asthma. Am J Respir Crit Care Med. 2005;171:224–230
  6. Bocek P, Foucras G, Paul WE. Interferon gamma enhances both in vitro and in vivo priming of CD41 T cells for IL-4 production. J Exp Med. 2004;199:1619–1630
  7. Sugimoto T, Ishikawa Y, Yoshimoto T, Hayashi N, Fujimoto J, Nakanishi K. Interleukin 18 acts on memory T helper cells type 1 to induce airway inflammation and hyperresponsiveness in a naive host mouse. J Exp Med. 2004;199:535–545
  8. Devadas S, Das J, Liu C, Zhang L, Roberts AI, Pan Z, et al. Granzyme B is critical for T cell receptor-induced cell death of type 2 helper T cells. Immunity. 2006;25:237–247
  9. Benson M, Carlsson L, Adner M, Jernås M, Rudemo M, Sjögren A, et al. Gene profiling reveals increased expression of uteroglobin and other anti-inflammatory genes in glucocorticoid-treated nasal polyps. J Allergy Clin Immunol. 2004;113:1137–1143

 Disclosure of potential conflict of interest: The authors have declared that they have no conflict of interest.

PII: S0091-6749(09)01438-9

doi: 10.1016/j.jaci.2009.09.037

The Journal of Allergy and Clinical Immunology
Volume 124, Issue 6 , Pages 1360-1362 , December 2009

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