The Journal of Allergy and Clinical Immunology
Volume 124, Issue 6 , Pages 1360-1362 , December 2009

Increased IFN-γ activity in seasonal allergic rhinitis is decreased by corticosteroid treatment

  • Hui Wang, MM

      Affiliations

    • Unit for Clinical Systems Biology, Queen Silvia Children's Hospital, University of Gothenburg, Gothenburg, Sweden
    • These authors contributed equally to this work.
    • ,
  • Fredrik Barrenäs, MS

      Affiliations

    • Unit for Clinical Systems Biology, Queen Silvia Children's Hospital, University of Gothenburg, Gothenburg, Sweden
    • These authors contributed equally to this work.
    • ,
  • Sören Bruhn, PhD

      Affiliations

    • Unit for Clinical Systems Biology, Queen Silvia Children's Hospital, University of Gothenburg, Gothenburg, Sweden
    • ,
  • Reza Mobini, PhD

      Affiliations

    • Unit for Clinical Systems Biology, Queen Silvia Children's Hospital, University of Gothenburg, Gothenburg, Sweden
    • ,
  • Mikael Benson, MD, PhD

      Affiliations

    • Unit for Clinical Systems Biology, Queen Silvia Children's Hospital, University of Gothenburg, Gothenburg, Sweden
    • Pediatric Allergy Unit, Queen Silvia Children's Hospital, Gothenburg, Sweden

  • Image Result

    The mean ± SEM mRNA (A) and protein levels (B) of IFN-γ (IFNG) in allergen-challenged CD4+ cells. A, n = 12 patients; B, n = 20 patients. ∗∗P < .01; ∗∗∗∗P < .0001.

    The mean ± SEM mRNA (A) and protein levels (B) of IFN-γ (IFNG) in allergen-challenged CD4+ cells. A, n = 12 patients; B, n = 20 patients. ∗∗P < .01; ∗∗∗∗P < .0001.

  • Image Result

    A module of IFN-γ (IFNG)–induced genes that were highly differentially expressed in allergen-challenged CD4+ cells (adjusted P < .01). n = 12 patients.

    A module of IFN-γ (IFNG)–induced genes that were highly differentially expressed in allergen-challenged CD4+ cells (adjusted P < .01). n = 12 patients.

  • Image Result

    The mRNA (A) and protein levels (B) of GZMA and GZMB in allergen-challenged CD4+ cells. A, n = 12 patients; B, n = 20 patients. ∗∗∗P < .001; ∗∗∗∗P < .0001.

    The mRNA (A) and protein levels (B) of GZMA and GZMB in allergen-challenged CD4+ cells. A, n = 12 patients; B, n = 20 patients. ∗∗∗P < .001; ∗∗∗∗P < .0001.

 Disclosure of potential conflict of interest: The authors have declared that they have no conflict of interest.

PII: S0091-6749(09)01438-9

doi: 10.1016/j.jaci.2009.09.037

The Journal of Allergy and Clinical Immunology
Volume 124, Issue 6 , Pages 1360-1362 , December 2009

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