The Journal of Allergy and Clinical Immunology
Volume 124, Issue 6 , Pages 1352-1354.e7 , December 2009

Pilot study of budesonide inhalant suspension irrigations for chronic eosinophilic sinusitis

  • John W. Steinke, PhD

      Affiliations

    • Department of Medicine, University of Virginia Health Systems, Charlottesville
    • ,
  • Spencer C. Payne, MD

      Affiliations

    • Department of Otolaryngology—Head and Neck Surgery, University of Virginia Health Systems, Charlottesville
    • ,
  • M. Elizabeth Tessier, MD

      Affiliations

    • Department of Medicine, University of Virginia Health Systems, Charlottesville
    • ,
  • Lori O. Borish, RN

      Affiliations

    • Department of Medicine, University of Virginia Health Systems, Charlottesville
    • ,
  • Joseph K. Han, MD

      Affiliations

    • Department of Otolaryngology—Head and Neck Surgery, Eastern Virginia Medical School, Norfolk
    • ,
  • Larry C. Borish, MD

      Affiliations

    • Department of Medicine, University of Virginia Health Systems, Charlottesville

References 

  1. Meltzer EO, Hamilos DL, Hadley JA, Lanza DC, Marple BF, Nicklas RA, et al. Rhinosinusitis: establishing definitions for clinical research and patient care. J Allergy Clin Immunol. 2004;114:S155–S212
  2. Poole MD. Pediatric sinusitis is not a surgical disease. Ear Nose Throat J. 1992;71:622–623
  3. Steinke JW, Bradley D, Arango P, Crouse CD, Frierson H, Kountakis SE, et al. Cysteinyl leukotriene expression in chronic hyperplastic sinusitis-nasal polyposis: importance to eosinophilia and asthma. J Allergy Clin Immunol. 2003;111:342–349
  4. Jankowski R, Bodino C. Evolution of symptoms associated to nasal polyposis following oral steroid treatment and nasalization of the ethmoid-radical ethmoidectomy is functional surgery for NPS. Rhinology. 2003;41:211–219
  5. Stjarne P, Blomgren K, Cayé-Thomasen P, Salo S, Soderstrom T. The efficacy and safety of once-daily mometasone furoate nasal spray in nasal polyposis: a randomized, double-blind, placebo-controlled study. Acta Otolaryngol. 2006;126:606–612
  6. Harvey R, Hannan SA, Badia L, Scadding G. Nasal saline irrigations for the symptoms of chronic rhinosinusitis. Cochrane Database Syst Rev. 2007;18:CD006394
  7. National Heart L, and Blood Institute. National Asthma Education and Prevention Program Expert Panel report 3: guidelines for the diagnosis and management of asthma. Bethesda (MD): National Institutes of Health; 2007;
  8. Bhattacharyya N. Clinical and symptom criteria for the accurate diagnosis of chronic rhinosinusitis. Laryngoscope. 2006;116:1–22
  9. Braunstahl GJ, Kleinjan A, Overbeek SE, Prins JB, Hoogsteden HC, Fokkens WJ. Segmental bronchial provocation induces nasal inflammation in allergic rhinitis patients. Am J Respir Crit Care Med. 2000;161:2051–2057

 Supported by National Institutes of Health grant nos. RO1 AI01793 and PO1 AI50989. Disclosure of potential conflict of interest: J. W. Steinke has received research support from the National Institutes of Health. S. C. Payne has received honoraria from Acclarent, Inc, has received research support from the American Academy of Otolaryngologic Allergy, and has provided legal consultation or expert witness testimony on the topic of tonsillectomies. L. C. Borish is on the speakers' bureau for Merck, is on an advisory board for Genentech and Novartis, and has received research support from Genentech and Merck. The rest of the authors have declared that they have no conflict of interest.

PII: S0091-6749(09)01406-7

doi: 10.1016/j.jaci.2009.09.018

The Journal of Allergy and Clinical Immunology
Volume 124, Issue 6 , Pages 1352-1354.e7 , December 2009

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