The Journal of Allergy and Clinical Immunology
Volume 125, Issue 2 , Pages 321-327.e13 , February 2010

Evaluation of candidate genes in a genome-wide association study of childhood asthma in Mexicans

  • Hao Wu, PhD

      Affiliations

    • Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC
  • ,
  • Isabelle Romieu, MD

      Affiliations

    • National Institute of Public Health, Cuernavaca, Mexico
  • ,
  • Min Shi, PhD

      Affiliations

    • Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC
  • ,
  • Dana B. Hancock, PhD

      Affiliations

    • Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC
  • ,
  • Huiling Li, MD

      Affiliations

    • Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC
  • ,
  • Juan-Jose Sienra-Monge, MD

      Affiliations

    • Hospital Infantil de Mexico Federico Gomez, Mexico City, Mexico
  • ,
  • Grace Y. Chiu, PhD

      Affiliations

    • Westat, Research Triangle Park, NC
  • ,
  • Hong Xu, MS

      Affiliations

    • Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC
  • ,
  • Blanca Estela del Rio-Navarro, MD

      Affiliations

    • Hospital Infantil de Mexico Federico Gomez, Mexico City, Mexico
  • ,
  • Stephanie J. London, MD

      Affiliations

    • Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC
    • Corresponding Author InformationReprint requests: Stephanie J. London, MD, National Institute of Environmental Health Sciences, PO Box 12233, MD A3-05, Research Triangle Park, NC 27709.

Received 6 April 2009 ,Revised 5 August 2009 ,Accepted 4 September 2009.

References 

  1. Moffatt MF, Kabesch M, Liang L, Dixon AL, Strachan D, Heath S, et al. Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma. Nature. 2007;448:470–473
  2. Li C, Li M, Lange EM, Watanabe RM. Prioritized subset analysis: improving power in genome-wide association studies. Hum Hered. 2008;65:129–141
  3. Ober C, Hoffjan S. Asthma genetics 2006: the long and winding road to gene discovery. Genes Immun. 2006;7:95–100
  4. Zhang J, Pare PD, Sandford AJ. Recent advances in asthma genetics. Respir Res. 2008;9:4
  5. Chanock SJ, Manolio T, Boehnke M, Boerwinkle E, Hunter DJ, Thomas G, et al. Replicating genotype-phenotype associations. Nature. 2007;447:655–660
  6. Rogers AJ, Raby BA, Lasky-Su JA, Murphy A, Lazarus R, Klanderman BJ, et al. Assessing the reproducibility of asthma candidate gene associations using genome-wide data. Am J Respir Crit Care Med. 2009;179:1084–1090
  7. Weinberg CR, Wilcox AJ, Lie RT. A log-linear approach to case-parent-triad data: assessing effects of disease genes that act either directly or through maternal effects and that may be subject to parental imprinting. Am J Hum Genet. 1998;62:969–978
  8. Wilcox AJ, Weinberg CR, Lie RT. Distinguishing the effects of maternal and offspring genes through studies of “case-parent triads”. Am J Epidemiol. 1998;148:893–901
  9. BTS/SIGN. British guideline on the management of asthma. Thorax. 2003;58(suppl 1):i1–i94
  10. National Heart, Lung, and Blood Institute. Pocket guide for asthma management and prevention: Global Initiative for Asthma. Bethesda: National Institutes of Health; 1998;
  11. American Thoracic Society. Standardization of spirometry, 1994 update. Am J Respir Crit Care Med. 1995;152:1107–1136
  12. Purcell S, Neale B, Todd-Brown K, Thomas L, Ferreira MA, Bender D, et al. PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet. 2007;81:559–575
  13. Thomas G, Jacobs KB, Yeager M, Kraft P, Wacholder S, Orr N, et al. Multiple loci identified in a genome-wide association study of prostate cancer. Nat Genet. 2008;40:310–315
  14. Barrett JC, Cardon LR. Evaluating coverage of genome-wide association studies. Nat Genet. 2006;38:659–662
  15. Li M, Li C, Guan W. Evaluation of coverage variation of SNP chips for genome-wide association studies. Eur J Hum Genet. 2008;16:635–643
  16. van Den Oord EJ, Vermunt JK. Testing for linkage disequilibrium, maternal effects, and imprinting with (In)complete case-parent triads, by use of the computer program LEM. Am J Hum Genet. 2000;66:335–338
  17. Storey JD, Tibshirani R. Statistical significance for genomewide studies. Proc Natl Acad Sci U S A. 2003;100:9440–9445
  18. van den Oord EJ, Sullivan PF. False discoveries and models for gene discovery. Trends Genet. 2003;19:537–542
  19. Shi M, Umbach DM, Weinberg CR. Identification of risk-related haplotypes with the use of multiple SNPs from nuclear families. Am J Hum Genet. 2007;81:53–66
  20. Vercelli D. Discovering susceptibility genes for asthma and allergy. Nat Rev Immunol. 2008;8:169–182
  21. Li H, Romieu I, Wu H, Sienra-Monge JJ, Ramirez-Aguilar M, del Rio-Navarro BE, et al. Genetic polymorphisms in transforming growth factor beta-1 (TGFB1) and childhood asthma and atopy. Hum Genet. 2007;121:529–538
  22. Dale M, Nicklin MJ. Interleukin-1 receptor cluster: gene organization of IL1R2, IL1R1, IL1RL2 (IL-1Rrp2), IL1RL1 (T1/ST2), and IL18R1 (IL-1Rrp) on human chromosome 2q. Genomics. 1999;57:177–179
  23. Dunne A, O'Neill LA. The interleukin-1 receptor/Toll-like receptor superfamily: signal transduction during inflammation and host defense. Sci STKE. 2003;2003:re3
  24. Schmitz J, Owyang A, Oldham E, Song Y, Murphy E, McClanahan TK, et al. IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines. Immunity. 2005;23:479–490
  25. Mangan NE, Dasvarma A, McKenzie AN, Fallon PG. T1/ST2 expression on Th2 cells negatively regulates allergic pulmonary inflammation. Eur J Immunol. 2007;37:1302–1312
  26. Cherry WB, Yoon J, Bartemes KR, Iijima K, Kita H. A novel IL-1 family cytokine, IL-33, potently activates human eosinophils. J Allergy Clin Immunol. 2008;121:1484–1490
  27. Oshikawa K, Kuroiwa K, Tago K, Iwahana H, Yanagisawa K, Ohno S, et al. Elevated soluble ST2 protein levels in sera of patients with asthma with an acute exacerbation. Am J Respir Crit Care Med. 2001;164:277–281
  28. Nakanishi K, Yoshimoto T, Tsutsui H, Okamura H. Interleukin-18 is a unique cytokine that stimulates both Th1 and Th2 responses depending on its cytokine milieu. Cytokine Growth Factor Rev. 2001;12:53–72
  29. Reijmerink NE, Postma DS, Bruinenberg M, Nolte IM, Meyers DA, Bleecker ER, et al. Association of IL1RL1, IL18R1, and IL18RAP gene cluster polymorphisms with asthma and atopy. J Allergy Clin Immunol. 2008;122:651–654e8
  30. Zhu G, Whyte MK, Vestbo J, Carlsen K, Carlsen KH, Lenney W, et al. Interleukin 18 receptor 1 gene polymorphisms are associated with asthma. Eur J Hum Genet. 2008;16:1083–1090
  31. Gudbjartsson DF, Bjornsdottir US, Halapi E, Helgadottir A, Sulem P, Jonsdottir GM, et al. Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction. Nat Genet. 2009;41:342–347
  32. Allen M, Heinzmann A, Noguchi E, Abecasis G, Broxholme J, Ponting CP, et al. Positional cloning of a novel gene influencing asthma from chromosome 2q14. Nat Genet. 2003;35:258–263
  33. Kere J, Laitinen T. Positionally cloned susceptibility genes in allergy and asthma. Curr Opin Immunol. 2004;16:689–694
  34. Blakey JD, Sayers I, Ring S, Strachan D, Hall I. Positionally cloned Asthma susceptibility gene polymorphisms and disease risk in the British 1958 Birth Cohort. Thorax. 2009;64:381–387
  35. Wu H, Romieu I, Sienra-Monge JJ, Li H, Del Rio-Navarro BE, London SJ. Genetic variation in ORM1-like 3 (ORMDL3) and gasdermin-like (GSDML) and childhood asthma. Allergy. 2009;64:629–635
  36. Jenkins MA, Clarke JR, Carlin JB, Robertson CF, Hopper JL, Dalton MF, et al. Validation of questionnaire and bronchial hyperresponsiveness against respiratory physician assessment in the diagnosis of asthma. Int J Epidemiol. 1996;25:609–616
  37. Hancock DB, Romieu I, Shi M, Sienra-Monge J-J, Wu H, Chiu GY, et al. Genome-wide association study implicates chromosome 9q21.31 as a susceptibility locus for asthma in Mexican children. PLoS Genet. 2009;5:e1000623

 Supported by the Intramural Research Program of the National Institutes of Health, National Institute of Environmental Health Sciences (Z01 ES49019). Subject enrollment was supported in part by the National Council of Science and Technology (grant 26206-M), Mexico. I. R. was supported in part by the National Center for Environmental Health at the Centers for Disease Control.

 Disclosure of potential conflict of interest: The authors have declared that they have no conflict of interest to disclose.

PII: S0091-6749(09)01336-0

doi: 10.1016/j.jaci.2009.09.007

The Journal of Allergy and Clinical Immunology
Volume 125, Issue 2 , Pages 321-327.e13 , February 2010