The Journal of Allergy and Clinical Immunology
Volume 125, Issue 2 , Pages 321-327.e13 , February 2010

Evaluation of candidate genes in a genome-wide association study of childhood asthma in Mexicans

  • Hao Wu, PhD

      Affiliations

    • Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC
    • ,
  • Isabelle Romieu, MD

      Affiliations

    • National Institute of Public Health, Cuernavaca, Mexico
    • ,
  • Min Shi, PhD

      Affiliations

    • Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC
    • ,
  • Dana B. Hancock, PhD

      Affiliations

    • Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC
    • ,
  • Huiling Li, MD

      Affiliations

    • Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC
    • ,
  • Juan-Jose Sienra-Monge, MD

      Affiliations

    • Hospital Infantil de Mexico Federico Gomez, Mexico City, Mexico
    • ,
  • Grace Y. Chiu, PhD

      Affiliations

    • Westat, Research Triangle Park, NC
    • ,
  • Hong Xu, MS

      Affiliations

    • Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC
    • ,
  • Blanca Estela del Rio-Navarro, MD

      Affiliations

    • Hospital Infantil de Mexico Federico Gomez, Mexico City, Mexico
    • ,
  • Stephanie J. London, MD

      Affiliations

    • Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC
    • Corresponding Author InformationReprint requests: Stephanie J. London, MD, National Institute of Environmental Health Sciences, PO Box 12233, MD A3-05, Research Triangle Park, NC 27709.

Received 6 April 2009 ,Revised 5 August 2009 ,Accepted 4 September 2009.

  • Image Result

    A, A summary of associations among 2933 autosomal SNPs in 237 candidate genes and childhood asthma in a Mexican population. The x-axis indicates the genomic position of all SNPs divided by chromosome.

    A, A summary of associations among 2933 autosomal SNPs in 237 candidate genes and childhood asthma in a Mexican population. The x-axis indicates the genomic position of all SNPs divided by chromosome. The y-axis shows the degree of association indicated as −log10 P value. B, Quantile-quantile plot. Distribution of the observed P values for the 2933 SNPs compared with the P values expected under the null hypothesis of no association. Observed −log10 P values are ranked in order on the y-axis and plotted against the corresponding expected −log10 P values on the x-axis. The red line indicates the null distribution.

  • Image Result
    Pairwise LD (r2) among IL1RL1, IL18R1, and DPP10 SNPs associated with asthma in a Mexican population (P < .05). SNPs with P values of less than .01 are indicated in green.

    Pairwise LD (r2) among IL1RL1, IL18R1, and DPP10 SNPs associated with asthma in a Mexican population (P < .05). SNPs with P values of less than .01 are indicated in green.

  • Image Result
    Pairwise LD (r2) among 8 TGFB1 SNPs that have been examined in our study population to date.E14 SNPs significantly associated with asthma are indicated in green.

    Pairwise LD (r2) among 8 TGFB1 SNPs that have been examined in our study population to date.E14 SNPs significantly associated with asthma are indicated in green.

 Supported by the Intramural Research Program of the National Institutes of Health, National Institute of Environmental Health Sciences (Z01 ES49019). Subject enrollment was supported in part by the National Council of Science and Technology (grant 26206-M), Mexico. I. R. was supported in part by the National Center for Environmental Health at the Centers for Disease Control.

 Disclosure of potential conflict of interest: The authors have declared that they have no conflict of interest to disclose.

PII: S0091-6749(09)01336-0

doi: 10.1016/j.jaci.2009.09.007

The Journal of Allergy and Clinical Immunology
Volume 125, Issue 2 , Pages 321-327.e13 , February 2010

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