The Journal of Allergy and Clinical Immunology
Volume 124, Issue 5 , Pages 913-920.e7, November 2009

Tissue remodeling induced by hypersecreted epidermal growth factor and amphiregulin in the airway after an acute asthma attack

  • Yukinori Enomoto, BSc

      Affiliations

    • Division of Molecular Cell Immunology and Allergology, Advanced Medical Research Center, Nihon University Graduate School of Medical Science, Tokyo, Japan
    • Department of Environmental Immuno-Dermatology, Yokohama City University School of Medicine, Kanagawa, Japan
    • ,
  • Kanami Orihara, PhD

      Affiliations

    • Department of Allergy and Immunology, National Research Institute for Child Health and Development, Tokyo, Japan
    • ,
  • Tetsuya Takamasu, MD

      Affiliations

    • Department of Allergy, Kanagawa Children's Medical Center, Kanagawa, Japan
    • Corresponding Author InformationTetsuya Takamasu, MD, Department of Allergy, Kanagawa Children's Medical Center, Kanagawa, Japan.
    • ,
  • Akio Matsuda, PhD

      Affiliations

    • Department of Allergy and Immunology, National Research Institute for Child Health and Development, Tokyo, Japan
    • ,
  • Yasuhiro Gon, MD, PhD

      Affiliations

    • Division of Molecular Cell Immunology and Allergology, Advanced Medical Research Center, Nihon University Graduate School of Medical Science, Tokyo, Japan
    • ,
  • Hirohisa Saito, MD, PhD

      Affiliations

    • Department of Allergy and Immunology, National Research Institute for Child Health and Development, Tokyo, Japan
    • ,
  • Chisei Ra, MD, PhD

      Affiliations

    • Division of Molecular Cell Immunology and Allergology, Advanced Medical Research Center, Nihon University Graduate School of Medical Science, Tokyo, Japan
    • ,
  • Yoshimichi Okayama, MD, PhD

      Affiliations

    • Division of Molecular Cell Immunology and Allergology, Advanced Medical Research Center, Nihon University Graduate School of Medical Science, Tokyo, Japan
    • Corresponding Author InformationReprint requests: Yoshimichi Okayama, MD, PhD, Division of Molecular Cell Immunology and Allergology, Advanced Medical Research Center, Nihon University Graduate School of Medical Science, 30-1 Oyaguchikami-machi, Itabashi-ku, Tokyo 173-8610, Japan.

Received 8 April 2009; received in revised form 23 July 2009; accepted 20 August 2009.

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    •  Supported in part by Grants-in-Aid for Scientific Research (C) programs of the Ministry of Education, Culture, Sports, Science and Technology of the Japanese Government (project nos. 18604009 and 20591195, awarded to Y.O.), the Nihon University Joint Research Grant for 2008 (awarded to Y.O), a grant from the National Institute of Biomedical Innovation (project no. ID05-24, awarded to H.S. and Y.O.), and the Matching Fund Subsidy for Private Universities from the Ministry of Education, Culture, Sports, Science and Technology of the Japanese Government (to C.R).

     Disclosure of potential conflict of interest: H. Saito has received research support from the National Institute of Biomedical Innovation. The rest of the authors have declared that they have no conflict of interest.

    PII: S0091-6749(09)01328-1

    doi:10.1016/j.jaci.2009.08.044

    The Journal of Allergy and Clinical Immunology
    Volume 124, Issue 5 , Pages 913-920.e7, November 2009