The Journal of Allergy and Clinical Immunology
Volume 124, Issue 6 , Pages 1197-1203 , December 2009

Dispensing of fluticasone propionate/salmeterol combination in the summer and asthma-related outcomes in the fall

  • Joseph Spahn, MD

      Affiliations

    • National Jewish Health, Denver, Colo
    • Corresponding Author InformationReprint requests: Joseph Spahn, MD, Ira J. and Jacqueline Neimark Laboratory of Clinical Pharmacology in Pediatrics, National Jewish Medical and Research Center, 1400 Jackson St, Denver, CO 80206.
    • ,
  • Ketan Sheth, MD, MBA

      Affiliations

    • Lafayette Allergy and Asthma Clinic, Lafayette, Ind
    • ,
  • Wei-Shi Yeh, MS

      Affiliations

    • University of North Carolina, Chapel Hill, NC
    • ,
  • David A. Stempel, MD

      Affiliations

    • GlaxoSmithKline, Research Triangle Park, NC
    • ,
  • Richard H. Stanford, PharmD, MS

      Affiliations

    • GlaxoSmithKline, Research Triangle Park, NC

Received 25 August 2008 ,Revised 9 July 2009 ,Accepted 6 August 2009.

References 

  1. Lin RY, Pitt TJ, Lou W, Yi Q. Asthma hospitalization patterns in young children relating to admission age, infection presence, sex, and race. Ann Allergy Asthma Immunol. 2007;98:139–145
  2. Gergen PJ, Mitchell H, Lynn H. Understanding the seasonal pattern of childhood asthma: results from the National Cooperative Inner-City Asthma Study (NCICAS). J Pediatr. 2002;141:631–636
  3. Sears MR, Johnston NW. Understanding the September asthma epidemic. J Allergy Clin Immunol. 2007;120:526–529
  4. Silverman RA, Ito K, Stevenson L, Hastings HM. The relationship of fall school opening and emergency department asthma visits in a large metropolitan area. Arch Pediatr Adolesc Med. 2005;159:818–823
  5. Fleming DM, Cross KW, Sunderland R, Ross AM. Comparison of the seasonal patterns of asthma identified in general practitioner episodes, hospital admissions, and deaths. Thorax. 2000;55:662–665
  6. Pendergraft TB, Stanford RH, Beasley R, Stempel DA, McLaughlin T. Seasonal variation in asthma-related hospital and intensive care unit admissions. J Asthma. 2005;42:265–271
  7. Johnston NW, Johnston SL, Duncan JM, Greene JM, Kebadze T, Roy M, et al. The September epidemic of asthma exacerbations in children: a search for etiology. J Allergy Clin Immunol. 2005;115:132–138
  8. Johnston NW, Johnston SL, Norman GR, Dai J, Sears MR. The September epidemic of asthma hospitalization: school children as disease vectors. J Allergy Clin Immunol. 2006;117:557–562
  9. Expert Panel report 3: guidelines for the diagnosis and management of asthma. Full report 2007. National Heart, Lung, and Blood Institute, National Institutes of Health, National Heart, Lung, and Blood Institute. Available at: http://www.nhlbi.nih.gov/guidelines/asthma/asthgdln.htm. Accessed August 21, 2008.
  10. Connett G, Lenney W. Prevention of viral induced asthma attacks using inhaled budesonide. Arch Dis Child. 1993;68:85–87
  11. Svedmyr J, Nyberg E, Thunqvist P, Asbrink-Nilsson E, Hedlin G. Prophylactic intermittent treatment with inhaled corticosteroids of asthma exacerbations due to airway infections in toddlers. Acta Paediatr. 1999;88:42–47
  12. Doull IJM. Limitations of maintenance therapy for viral respiratory infection-induced asthma. J Pediatr. 2003;142:S21–S25
  13. Braitman LE, Rosenbaum PR. Rare outcomes, common treatments: analytic strategies using propensity scores. Ann Intern Med. 2002;137:693–695
  14. Cepeda MS, Boston R, Farrar JT, Strom BL. Comparison of logistic regression versus propensity score when the number of events is low and there are multiple confounders. Am J Epidemiol. 2003;158:280–287
  15. D'Agostino RB. Propensity score methods for bias reduction in the comparison of a treatment to a non-randomized control group. Stat Med. 1998;17:2265–2281
  16. Joffe MM, Rosenbaum PR. Invited commentary: propensity scores. Am J Epidemiol. 1999;150:327–333
  17. Stone RA, Obrosky DS, Singer DE, Kapoor WN, Fine MJ. Propensity score adjustment for pretreatment differences between hospitalized and ambulatory patients with community-acquired pneumonia. Pneumonia Patient Outcomes Research Team (PORT) Investigators. Med Care. 1995;33:AS56–AS66
  18. Laitinen LA, Laitinen A, Haahtela T. A comparative study of the effects of an inhaled corticosteroid, budesonide, and a beta 2-agonist, terbutaline, on airway inflammation in newly diagnosed asthma: a randomized, double-blind, parallel-group controlled trial. J Allergy Clin Immunol. 1992;90:32–42
  19. Chanez P, Bourdin A, Vachier I, Godard P, Bousquet J, Vignola AM. Effects of inhaled corticosteroids on pathology in asthma and chronic obstructive pulmonary disease. Proc Am Thorac Soc. 2004;1:184–190
  20. Orsida BE, Ward C, Li X, Bish R, Wilson JW, Thien F, et al. Effect of a long-acting beta2-agonist over three months on airway wall vascular remodeling in asthma. Am J Respir Crit Care Med. 2001;164:117–121
  21. Wallin A, Sue-Chu M, Bjermer L, Ward J, Sandström T, Lindberg A, et al. Effect of inhaled fluticasone with and without salmeterol on airway inflammation in asthma. J Allergy Clin Immunol. 2003;112:72–78
  22. Dowling RB, Johnson M, Cole PJ, Wilson R. Effect of fluticasone propionate and salmeterol on Pseudomonas aeruginosa infection of the respiratory mucosa in vitro. Eur Respir J. 1999;14:363–369
  23. Nelson HS, Chapman KR, Pyke SD, Johnson M, Pritchard JN. Enhanced synergy between fluticasone propionate and salmeterol inhaled from a single inhaler versus separate inhalers. J Allergy Clin Immunol. 2003;112:29–36
  24. Bateman ED, Boushey HA, Bousquet J, Busse WW, Clark TJH, Pauwels RA, et al. Can guideline-defined asthma control be achieved? the gaining optimal asthma control study. Am J Respir Crit Care Med. 2004;170:836–855
  25. Pauwels RA, Pedersen S, Busse WW, Tan WC, Chen YZ, Ohlsson SV, et al. Early intervention with budesonide in mild persistent asthma: a randomized, double-blind trial. Lancet. 2003;361:1071–1076

 Supported by GlaxoSmithKline, Research Triangle Park, NC.

 Disclosure of potential conflict of interest: R. H. Stanford and D. A. Stempel are employees of GlaxoSmithKline. J. Spahn has received honoraria and served as a consultant for GlaxoSmithKline, has received research support from Merck, and has served as an expert witness for GlaxoSmithKline. K. Sheth has received honoraria from Alcon, AstraZeneca, and Sanofi; has served as a consultant for Sepracor (Altana); and has received honoraria and served as a consultant for GlaxoSmithKline. W.-S. Yeh has received consulting fees from GlaxoSmithKline.

PII: S0091-6749(09)01325-6

doi: 10.1016/j.jaci.2009.08.042

The Journal of Allergy and Clinical Immunology
Volume 124, Issue 6 , Pages 1197-1203 , December 2009

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