The Journal of Allergy and Clinical Immunology
Volume 125, Issue 1 , Pages 184-190.e1 , January 2010

Reassessing the role of hyaluronidase in yellow jacket venom allergy

  • Chunsheng Jin, PhD

      Affiliations

    • Department of Chemistry, University of Natural Resources and Applied Life Sciences, Vienna, Austria
    • ,
  • Margarete Focke, PhD

      Affiliations

    • Institute of Pathophysiology, Medical University of Vienna, Vienna, Austria
    • ,
  • Renaud Léonard, PhD

      Affiliations

    • Department of Chemistry, University of Natural Resources and Applied Life Sciences, Vienna, Austria
    • ,
  • Reinhart Jarisch, MD

      Affiliations

    • FAZ–Floridsdorf Allergy Centre, Vienna, Austria
    • ,
  • Friedrich Altmann, PhD

      Affiliations

    • Department of Chemistry, University of Natural Resources and Applied Life Sciences, Vienna, Austria
    • ,
  • Wolfgang Hemmer, PhD

      Affiliations

    • FAZ–Floridsdorf Allergy Centre, Vienna, Austria
    • Corresponding Author InformationReprint requests: Wolfgang Hemmer, PhD, FAZ–Floridsdorf Allergy Centre, Franz-Jonas-Platz 8/6, A-1210 Vienna, Austria.

Received 13 February 2009 ,Revised 3 August 2009 ,Accepted 10 August 2009.

References 

  1. Kemparaju K, Girish KS. Snake venom hyaluronidase: a therapeutic target. Cell Biochem Funct. 2006;24:7–12
  2. Kemeny DM, Harries MG, Youlten LJ, Mackenzie-Mills M, Lessof MH. Antibodies to purified bee venom proteins and peptidases. I. Development of a highly specific RAST for bee venom antigens and its application to bee sting allergy. J Allergy Clin Immunol. 1983;71:505–514
  3. Kemeny DM, Dalton N, Lawrence AJ, Pearce FL, Vernon CA. The purification and characterisation of hyaluronidase from the venom of the honey bee, Apis mellifera. Eur J Biochem. 1984;139:217–223
  4. Kettner A, Henry H, Hughes GJ, Corradin G, Spertini F. IgE and T-cell responses to high-molecular weight allergens from bee venom. Clin Exp Allergy. 1999;29:394–401
  5. King TP, Sobotka AK, Alagon A, Kochoumian L, Lichtenstein LM. Protein allergens of white-faced hornet, yellow hornet, and yellow jacket venoms. Biochemistry. 1978;17:5165–5174
  6. Hoffman DR, Wood CL. Allergens in hymenoptera venom XI. Isolation of protein allergens from Vespula maculifrons (yellow jacket) venom. J Allergy Clin Immunol. 1984;74:93–103
  7. King T, Joslyn A, Kochoumian L. Antigenic cross-reactivity of venom proteins from hornets, wasps and yellow jackets. J Allergy Clin Immunol. 1985;75:621–628
  8. Hoffman DR. Allergens in Hymenoptera venoms XVI. Studies of the structures and cross-reactivities of vespid venom phospholipases. J Allergy Clin Immunol. 1986;78:337–343
  9. King TP, Lu G, Gonzales M, Qian N, Soldatova L. Yellow jacket venom allergens, hyaluronidase and phospholipase: sequence similarity and antigenic cross-reactivity with hornet and wasp homologs and possible implications for clinical allergy. J Allergy Clin Immunol. 1996;98:588–600
  10. Wypych J, Abenounis C, Reisman R. Analysis of differing patterns of cross-reactivity of honey bee and yellow jacket venom-specific IgE: use of purified venom fractions. Int Arch Allergy Appl Immunol. 1989;89:60–66
  11. Lu G, Kochoumian L, King TP. Sequence identity and antigenic cross reactivity of white face hornet venom allergen, also a hyaluronidase, with other proteins. J Biol Chem. 1995;270:4457–4465
  12. Hoffman D, Miller J, Sutton J. Hymenoptera venom allergy: a geographic study. Ann Allergy. 1980;45:276–279
  13. Egner W, Ward C, Brown DL, Ewan PW. The frequency and clinical significance of specific IgE to both wasp (Vespula) and honey-bee (Apis) venoms in the same patient. Clin Exp Allergy. 1998;28:26–34
  14. Hemmer W, Focke M, Kolarich D, Wilson IB, Altmann F, Wöhrl S, et al. Antibody binding to venom carbohydrates is a frequent cause for double positivity to honeybee and yellow jacket venom in patients with stinging-insect allergy. J Allergy Clin Immunol. 2001;108:1045–1052
  15. Jappe U, Raulf-Heimsoth M, Hoffmann M, Burow G, Hübsch-Müller C, Enk A. In vitro hymenoptera venom allergy diagnosis: improved by screening for cross-reactive carbohydrate determinants and reciprocal inhibition. Allergy. 2006;61:1220–1229
  16. Müller UR, Johansen N, Petersen AB, Fromberg-Nielsen J, Haeberli G. Hymenoptera venom allergy: analysis of double positivity to honey bee and Vespula venom by estimation of IgE antibodies to species-specific major allergens Api m1 and Ves v5. Allergy. 2009;64:543–548
  17. Hemmer W, Focke M, Kolarich D, Dalik I, Götz M, Jarisch R. Identification by immunoblot of venom glycoproteins displaying immunoglobulin E-binding N-glycans as cross-reactive allergens in honeybee and yellow jacket venom. Clin Exp Allergy. 2004;34:460–469
  18. Kochuyt A-M, Van Hoeyveld EM, Stevens EAM. Prevalence and clinical relevance of specific IgE to pollen caused by sting induced specific IgE to cross reacting carbohydrate determinants in Hymenoptera venoms. Clin Exp Allergy. 2005;35:441–447
  19. Mari A. IgE to cross-reactive carbohydrate determinants: analysis of the distribution and appraisal of the in vivo and in vitro reactivity. Int Arch Allergy Immunol. 2002;129:286–295
  20. Altmann F. The role of protein glycosylation in allergy. Int Arch Allergy Immunol. 2007;142:99–115
  21. Jin C, Hantusch B, Hemmer W, Stadlmann J, Altmann F. Affinity of IgE and IgG against cross-reactive carbohydrate determinants on plant and insect glycoproteins. J Allergy Clin Immunol. 2008;121:185–190
  22. King TP, Alagon AC, Kuan J, Sobotka AK, Lichtenstein LM. Immunochemical studies of yellow jacket venom proteins. Mol Immunol. 1983;20:297–308
  23. Kubelka V, Altmann F, März L. The asparagine-linked carbohydrate of honeybee venom hyaluronidase. Glycoconj J. 1995;12:77–83
  24. Kolarich D, Altmann F. N-Glycan analysis by matrix-assisted laser desorption/ionization mass spectrometry of electrophoretically separated nonmammalian proteins: application to peanut allergen Ara h 1 and olive pollen allergen Ole e 1. Anal Biochem. 2000;285:64–75
  25. Kolarich D, Léonard R, Hemmer W, Altmann F. The N-glycans of yellow jacket venom hyaluronidases and the protein sequence of its major isoform in Vespula vulgaris. FEBS J. 2005;272:5182–5190
  26. Kolarich D, Loos A, Léonard R, Mach L, Marzban G, Hemmer W, et al. A proteomic study of the major allergens from yellow jacket venoms. Proteomics. 2007;7:1615–1623
  27. Hoffman DR. Hymenoptera venom allergens. Clin Rev Allergy Immunol. 2006;30:109–128
  28. Skov LK, Seppälä U, Coen JJ, Crickmore N, King TP, Monsalve R, et al. Structure of recombinant Ves v 2 at 2.0 Angstrom resolution: structural analysis of an allergenic hyaluronidase from wasp venom. Acta Crystallogr D Biol Crystallogr. 2006;62:595–604
  29. Marković-Housley Z, Miglierini G, Soldatova L, Rizkallah PJ, Müller U, Schirmer T. Crystal structure of hyaluronidase, a major allergen of bee venom. Structure. 2000;8:1025–1035
  30. Wilson IB, Harthill JE, Mullin NP, Ashford DA, Altmann F. Core alpha1,3-fucose is a key part of the epitope recognized by antibodies reacting against plant N-linked oligosaccharides and is present in a wide variety of plant extracts. Glycobiology. 1998;8:651–661
  31. Müller UR. Recombinant Hymenoptera venom allergens. Allergy. 2002;57:570–576
  32. Hoffman DR. Allergens in Hymenoptera venom. XXV: the amino acid sequences of antigen 5 molecules and the structural basis of antigenic cross-reactivity. J Allergy Clin Immunol. 1993;92:707–716
  33. Soldatova LN, Crameri R, Gmachl M, Kemeny DM, Schmidt M, Weber M, et al. Superior biologic activity of the recombinant bee venom allergen hyaluronidase expressed in baculovirus-infected insect cells as compared with Escherichia coli. J Allergy Clin Immunol. 1998;101:691–698
  34. Kubelka V, Altmann F, Kornfeld G, März L. Structures of the N-linked oligosaccharides of the membrane glycoproteins from three lepidopteran cell lines (Sf-21, IZD-Mb-0503, Bm-N). Arch Biochem Biophys. 1994;308:148–157
  35. Soldatova LN, Tsai C, Dobrovolskaia E, Marković-Housley Z, Slater JE. Characterization of the N-glycans of recombinant bee venom hyaluronidase (Api m 2) expressed in insect cells. Allergy Asthma Proc. 2007;28:210–215
  36. Tomiya N, Narang S, Lee YC, Betenbaugh MJ. Comparing N-glycan processing in mammalian cell lines to native and engineered lepidopteran insect cell lines. Glycoconj J. 2004;21:343–360
  37. Müller UR, Fricker M, Wymann D, Blaser K, Crameri R. Increased specificity of diagnostic tests with recombinant major bee venom allergen phospholipase A2. Clin Exp Allergy. 1997;27:915–920
  38. Müller UR. Insect sting allergy. Clinical picture, diagnosis and treatment. Stuttgart, New York: Gustav Fischer; 1990;

 Supported by the FAZ–Floridsdorf Allergy Centre and grant S8803 from the Austrian Science Foundation.

 Disclosure of potential conflict of interest: F. Altmann has received research support from the European Community, the Austrian Science Fund, and Austria Wirtschaftsservice. The rest of the authors have declared that they have no conflict of interest.

PII: S0091-6749(09)01319-0

doi: 10.1016/j.jaci.2009.08.037

The Journal of Allergy and Clinical Immunology
Volume 125, Issue 1 , Pages 184-190.e1 , January 2010

Article Tools

* Image Usage & Resolution