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Volume 125, Issue 2 , Pages 336-346.e4, February 2010

A genome-wide association study on African-ancestry populations for asthma

Rasika A. Mathias, ScD
- Inherited Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Baltimore, Md
Audrey V. Grant, PhD
- Division of Allergy and Clinical Immunology, Department of Medicine, the Johns Hopkins University, Baltimore, Md
Nicholas Rafaels, MS
- Division of Allergy and Clinical Immunology, Department of Medicine, the Johns Hopkins University, Baltimore, Md
Tracey Hand, MS
- Division of Allergy and Clinical Immunology, Department of Medicine, the Johns Hopkins University, Baltimore, Md
Li Gao, MD, PhD
- Division of Allergy and Clinical Immunology, Department of Medicine, the Johns Hopkins University, Baltimore, Md
Candelaria Vergara, MSc
- Division of Allergy and Clinical Immunology, Department of Medicine, the Johns Hopkins University, Baltimore, Md
Yuhjung J. Tsai, MD
- Division of Allergy and Clinical Immunology, Department of Medicine, the Johns Hopkins University, Baltimore, Md
Mao Yang, MS
- Division of Allergy and Clinical Immunology, Department of Medicine, the Johns Hopkins University, Baltimore, Md
Monica Campbell, BS
- Division of Allergy and Clinical Immunology, Department of Medicine, the Johns Hopkins University, Baltimore, Md
Cassandra Foster
- Division of Allergy and Clinical Immunology, Department of Medicine, the Johns Hopkins University, Baltimore, Md
Peisong Gao, MD, PhD
- Division of Allergy and Clinical Immunology, Department of Medicine, the Johns Hopkins University, Baltimore, Md
A. Togias, MD
- Division of Allergy and Clinical Immunology, Department of Medicine, the Johns Hopkins University, Baltimore, Md
Nadia N. Hansel, MD, MPH
- Pulmonary and Critical Care Medicine, Department of Medicine, the Johns Hopkins University, Baltimore, Md
Gregory Diette, MD
- Pulmonary and Critical Care Medicine, Department of Medicine, the Johns Hopkins University, Baltimore, Md
N. Franklin Adkinson, MD
- Division of Allergy and Clinical Immunology, Department of Medicine, the Johns Hopkins University, Baltimore, Md
Mark C. Liu, MD
- Pulmonary and Critical Care Medicine, Department of Medicine, the Johns Hopkins University, Baltimore, Md
Mezbah Faruque, MD, PhD
- National Human Genome Center at Howard University, Washington, DC
Georgia M. Dunston, PhD
- National Human Genome Center at Howard University, Washington, DC
Harold R. Watson, MD
- University of the West Indies, Barbados, West Indies
Michael B. Bracken, PhD
- Department of Epidemiology and Public Health, Yale University, New Haven, Conn
Josephine Hoh, PhD
- Department of Epidemiology and Public Health, Yale University, New Haven, Conn
Pissamai Maul, RN
- University of the West Indies, Barbados, West Indies
Trevor Maul, RN
- University of the West Indies, Barbados, West Indies
Anne E. Jedlicka, MS
- Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Md
Tanda Murray, MS
- Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Md
Jacqueline B. Hetmanski, MS
- Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Md
Roxann Ashworth, MHS
- Center for Inherited Disease Research, Institute of Genetic Medicine, Johns Hopkins School of Medicine, Baltimore, Md
Chrissie M. Ongaco, BS
- Center for Inherited Disease Research, Institute of Genetic Medicine, Johns Hopkins School of Medicine, Baltimore, Md
Kurt N. Hetrick, MS
- Center for Inherited Disease Research, Institute of Genetic Medicine, Johns Hopkins School of Medicine, Baltimore, Md
Kimberly F. Doheny, PhD
- Center for Inherited Disease Research, Institute of Genetic Medicine, Johns Hopkins School of Medicine, Baltimore, Md
Elizabeth W. Pugh, PhD, MPH
- Center for Inherited Disease Research, Institute of Genetic Medicine, Johns Hopkins School of Medicine, Baltimore, Md
Charles N. Rotimi, PhD
- Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, Md
Jean Ford, MD
- Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Md
Celeste Eng, BS
- Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of California, San Francisco, Calif
Esteban G. Burchard, MD
- Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of California, San Francisco, Calif
Patrick M.A. Sleiman, PhD
- Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, Pa
Hakon Hakonarson, MD, PhD
- Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, Pa
Erick Forno, MD
- Channing Laboratory, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass
Benjamin A. Raby, MD
- Channing Laboratory, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass
Scott T. Weiss, MD
- Channing Laboratory, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass
Alan F. Scott, PhD
- Center for Inherited Disease Research, Institute of Genetic Medicine, Johns Hopkins School of Medicine, Baltimore, Md
Michael Kabesch, MD
- University Children's Hospital, Ludwig-Maximilians-Universität, Munich, Germany
Liming Liang, MS
- Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Mich
Gonçalo Abecasis, PhD
- Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Mich
Miriam F. Moffatt, PhD
- National Heart and Lung Institute, Imperial College, London, United Kingdom
William O.C. Cookson, MD
- National Heart and Lung Institute, Imperial College, London, United Kingdom
Ingo Ruczinski, PhD
- Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Baltimore, Md
Terri H. Beaty, PhD
- Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Md
Kathleen C. Barnes, PhD
- Division of Allergy and Clinical Immunology, Department of Medicine, the Johns Hopkins University, Baltimore, Md
- Pulmonary and Critical Care Medicine, Department of Medicine, the Johns Hopkins University, Baltimore, Md
- Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Md
- Reprint requests: Kathleen C. Barnes, PhD, the Johns Hopkins Asthma & Allergy Center, 5501 Hopkins Bayview Circle, Room 3A.62, Baltimore, MD 21224.

Received 24 June 2009; received in revised form 6 August 2009; accepted 21 August 2009. published online 12 November 2009.

Full Text Available

Supported by National Institutes of Health grants HL087699, HL49612, AI50024, AI44840, HL075417, HL072433, AI41040, ES09606, HL072433, and RR03048 and US Environmental Protection Agency grant 83213901, and NIGMS grant S06GM08015. The genome-wide genotyping of the European study was funded by the Wellcome Trust, the Medical Research Council, the French Ministry of Higher Education and Research, the German Ministry of Education and Research (BMBF), the National Genome Research Network (NGFN), the National Institutes of Health (National Human Genome Research Institute and National Heart, Lung, and Blood Institute; G. R. A.), and the European Commission as part of GABRIEL (a multidisciplinary study to identify the genetic and environmental causes of asthma in the European Community). K. C. B. was supported in part by the Mary Beryl Patch Turnbull Scholar Program. R. A. M. was supported by the Intramural Research Program of the National Human Genome Research Institute, National Institutes of Health.

Disclosure of potential conflict of interest: R. A. Mathias, L. Gao, P. Gao, C. M. Ongaco, K. N. Hetrick, K. F. Doheny, E. W. Pugh, A. F. Scott I. Ruczinski, T. H. Beaty, and K. C. Barnes have received research support from the National Institutes of Health. N. N. Hansel has received research support from Pfizer. N. F. Adkinson has equity ownership in AllerQuest LLC, has received research support from the National Institutes of Health, and has provided expert testimony on the topic of drug hypersensitivity. M. C. Liu is a consultant for the Novartis Advisory Board and has received research support from Pfizer, Centocor, and Novartis. J. Ford is a consultant for GlaxoSmithKline and has received research support from the National Institutes of Health and the Centers for Medicare and Medicaid Services. B. A. Raby is the Section Editor for Up to Date and is an in-house lecturer for Novartis Pharmaceuticals. S. T. Weiss has received research support from Genentech. M. Kabesch has financial arrangements with Roxall, Glaxo Wellcome, Novartis, Sanofi Aventis, and Allergopharma and has received research support from DFG, BMBF, and the European Union. G. Abecasis has received research support from GlaxoSmithKline and the National Institutes of Health. The rest of the authors have declared they have no conflict of interest.

PII: S0091-6749(09)01316-5

doi:10.1016/j.jaci.2009.08.031

« Previous Next »The Journal of Allergy and Clinical Immunology
Volume 125, Issue 2 , Pages 336-346.e4, February 2010