The Journal of Allergy and Clinical Immunology
Volume 124, Issue 5 , Pages 1005-1011.e1 , November 2009

Nasal inflammatory mediators and specific IgE production after nasal challenge with grass pollen in local allergic rhinitis

  • Carmen Rondón, MD, PhD

      Affiliations

    • Allergy Service, Carlos Haya Hospital, Málaga, Spain
    • Corresponding Author InformationReprint requests: Carmen Rondón, MD, PhD, Laboratorio de Investigación, Hospital Civil, pabellón 5, sótano, Plaza del Hospital Civil, 29009 Málaga, Spain.
    • ,
  • Javier Fernández, MD, PhD

      Affiliations

    • Allergy Service, Hospital Universitario de Elche, Alicante, Spain
    • ,
  • Soledad López, PhD

      Affiliations

    • Research Laboratory, Carlos Haya Hospital—Fundacion IMABIS, Málaga, Spain
    • ,
  • Paloma Campo, MD

      Affiliations

    • Allergy Service, Carlos Haya Hospital, Málaga, Spain
    • ,
  • Inmaculada Doña, MD

      Affiliations

    • Allergy Service, Carlos Haya Hospital, Málaga, Spain
    • ,
  • Maria J. Torres, MD, PhD

      Affiliations

    • Allergy Service, Carlos Haya Hospital, Málaga, Spain
    • ,
  • Cristobalina Mayorga, PhD

      Affiliations

    • Research Laboratory, Carlos Haya Hospital—Fundacion IMABIS, Málaga, Spain
    • ,
  • Miguel Blanca, MD, PhD

      Affiliations

    • Allergy Service, Carlos Haya Hospital, Málaga, Spain

Received 5 February 2009 ,Revised 7 May 2009 ,Accepted 1 July 2009.

  • Image Result

    Changes in total VAS symptoms in all patients with LAR (left), and between immediate (■) and dual (□) responders (right) after NAPT-grass. Significant differences between baseline and 15 minutes and 1

    Changes in total VAS symptoms in all patients with LAR (left), and between immediate (■) and dual (□) responders (right) after NAPT-grass. Significant differences between baseline and 15 minutes and 1, 6, and 24 hours after challenge are indicated by ∗P < .05 and ∗∗P < .001. Significant differences between immediate and dual responders are indicated by +P < .05). Data are expressed as means and SDs.

  • Image Result
    Changes in VOL 2-6cm in all patients with LAR (left), and between immediate (■) and dual (□) responders (right) after NAPT-grass. Significant differences between baseline and 15 minutes and 1, 6, and

    Changes in VOL 2-6cm in all patients with LAR (left), and between immediate (■) and dual (□) responders (right) after NAPT-grass. Significant differences between baseline and 15 minutes and 1, 6, and 24 hours after challenge are indicated by ∗P < .05 and ∗∗P < .001. Significant differences between immediate and dual responders are indicated by +P < .05. Data are expressed as means and SDs.

  • Image Result
    Nasal levels of tryptase in all patients with LAR (left), and between immediate (■) and dual (□) responders (right) after NAPT-grass. Significant differences between baseline and 15 minutes and 1, 6,

    Nasal levels of tryptase in all patients with LAR (left), and between immediate (■) and dual (□) responders (right) after NAPT-grass. Significant differences between baseline and 15 minutes and 1, 6, and 24 hours after challenge are indicated by ∗P < .05. Significant differences between immediate and dual responders are indicated by +P < .05. Data are expressed as means and SDs.

  • Image Result
    Nasal levels of ECP in all patients with LAR (left) and between immediate (■) and dual (□) responders (right) after NAPT-grass. Significant differences between baseline and 15 minutes and 1, 6, and 24

    Nasal levels of ECP in all patients with LAR (left) and between immediate (■) and dual (□) responders (right) after NAPT-grass. Significant differences between baseline and 15 minutes and 1, 6, and 24 hours after challenge are indicated by ∗P < .05. No significant differences between immediate and dual responders were found. Data are expressed as means and SDs.

  • Image Result
    Nasal levels of sIgE in all patients with LAR (left), and between immediate (■) and dual (□) responders (right) after NAPT-grass. Significant differences between baseline and 15 minutes and 1, 6, and

    Nasal levels of sIgE in all patients with LAR (left), and between immediate (■) and dual (□) responders (right) after NAPT-grass. Significant differences between baseline and 15 minutes and 1, 6, and 24 hours after challenge are indicated by ∗P < .05. No significant differences between immediate and dual responders were found. Data are expressed as means and SDs.

  • Image Result
    A-D, Correlation of nasal levels of tryptase (y-axis) with intensity of nasal symptoms (x-axis) after NAPT-grass in patients with LAR: nasal itching (A, Spearman r = 0.788, P = .001), sneezing (B, Spe

    A-D, Correlation of nasal levels of tryptase (y-axis) with intensity of nasal symptoms (x-axis) after NAPT-grass in patients with LAR: nasal itching (A, Spearman r = 0.788, P = .001), sneezing (B, Spearman r = 0.763, P = .001), rhinorrhea (C, Spearman r = 0.505, P = .001), and nasal obstruction (D, Spearman r = 0.425, P = .003). E, Correlation of nasal levels of ECP with intensity of nasal obstruction after NAPT-grass in patients with LAR (Spearman r = 0.559, P = .001).

 This work was supported by grants from Spanish Health Ministry (FIS) (PI081572), “Consejeria de Salud” Andalusia government (PI0181) and FIS network RIRAAF (RD07/0064).

 Disclosure of potential conflict of interest: The authors have declared that they have no conflict of interest.

PII: S0091-6749(09)01086-0

doi: 10.1016/j.jaci.2009.07.018

The Journal of Allergy and Clinical Immunology
Volume 124, Issue 5 , Pages 1005-1011.e1 , November 2009

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