The Journal of Allergy and Clinical Immunology
Volume 124, Issue 4 , Pages 681-687.e3 , October 2009

Phenotypic determinants of uncontrolled asthma

  • Valérie Siroux, PhD

      Affiliations

    • INSERM, Institut National de la Santé et de la Recherche Médicale, U823, Institut Albert Bonniot, Grenoble, France
    • Université Joseph Fourier, Grenoble, France
    • Corresponding Author InformationReprint requests: Valérie Siroux, Centre de Recherche INSERM/UJF U823, Institut Albert Bonniot, BP 170, 38042 Grenoble Cedex 9, France.
    • ,
  • Anne Boudier, MSc

      Affiliations

    • INSERM, Institut National de la Santé et de la Recherche Médicale, U823, Institut Albert Bonniot, Grenoble, France
    • Université Joseph Fourier, Grenoble, France
    • ,
  • Jean Bousquet, MD

      Affiliations

    • CHU Centre Hospitalier Universitaire, Montpellier, France
    • INSERM, Institut National de la Santé et de la Recherche Médicale, U780, Villejuif, France
    • ,
  • Jean-Louis Bresson, MD

      Affiliations

    • CIC, Centre d'Investigation Clinique, Necker, Paris, France
    • ,
  • Jean-Luc Cracowski, MD

      Affiliations

    • INSERM, Institut National de la Santé et de la Recherche Médicale CIC3, Grenoble, France
    • ,
  • Joane Ferran, BSc

      Affiliations

    • Clinique de Pneumology, CHU, Grenoble, France
    • ,
  • Frédéric Gormand, MD

      Affiliations

    • CHU, Lyon, France
    • ,
  • Jocelyne Just, MD

      Affiliations

    • Hopital Trousseau, Paris, France
    • ,
  • Nicole Le Moual, PhD

      Affiliations

    • INSERM, Institut National de la Santé et de la Recherche Médicale, U780, Villejuif, France
    • Univ Paris-Sud, IFR69, Villejuif, France
    • ,
  • Sophie Morange, MD

      Affiliations

    • CIC, Marseille, France
    • ,
  • Rachel Nadif, PhD

      Affiliations

    • INSERM, Institut National de la Santé et de la Recherche Médicale, U780, Villejuif, France
    • Univ Paris-Sud, IFR69, Villejuif, France
    • ,
  • Marie-Pierre Oryszczyn, BSc

      Affiliations

    • INSERM, Institut National de la Santé et de la Recherche Médicale, U780, Villejuif, France
    • Univ Paris-Sud, IFR69, Villejuif, France
    • ,
  • Christophe Pison, MD

      Affiliations

    • INSERM, Institut National de la Santé et de la Recherche Médicale, U780, Villejuif, France
    • Clinique de Pneumology, CHU, Grenoble, France
    • Institut National de la Santé et de la Recherche Médicale U884, Grenoble, France
    • ,
  • Pierre Scheinmann, MD

      Affiliations

    • Hopital Necker, Paris, France
    • Université Paris Descartes, Paris, France
    • ,
  • Raphaëlle Varraso, PhD

      Affiliations

    • INSERM, Institut National de la Santé et de la Recherche Médicale, U780, Villejuif, France
    • Univ Paris-Sud, IFR69, Villejuif, France
    • ,
  • Daniel Vervloet, MD

      Affiliations

    • CIC, Marseille, France
    • ,
  • Isabelle Pin, MD

      Affiliations

    • INSERM, Institut National de la Santé et de la Recherche Médicale, U823, Institut Albert Bonniot, Grenoble, France
    • Université Joseph Fourier, Grenoble, France
    • Pédiatrie, CHU, Grenoble, France
    • ,
  • Francine Kauffmann, MD

      Affiliations

    • INSERM, Institut National de la Santé et de la Recherche Médicale, U780, Villejuif, France
    • Univ Paris-Sud, IFR69, Villejuif, France
    • ,
  • Epidemiological Study on the Genetics and Environment of Asthma

Received 5 January 2009 ,Revised 11 May 2009 ,Accepted 1 June 2009.

  • Image Result

    Level of asthma treatment in the past 3 months following the GINA 2006 guidelines according to asthma control among ICS users in the past year.

    Level of asthma treatment in the past 3 months following the GINA 2006 guidelines according to asthma control among ICS users in the past year.

  • Image Result

    Adjusted risks between asthma control and sociodemographic and clinical characteristics, according to ICS use in the past 12 months. OR estimated by multivariate logistic regression with further adjus

    Adjusted risks between asthma control and sociodemographic and clinical characteristics, according to ICS use in the past 12 months. OR estimated by multivariate logistic regression with further adjustement on age, educational level, smoking, age at asthma onset, rhinitis, sensitization to indoor allergens, sensitization to outdoor allergens, and center. None of these factors were significantly related to asthma control in ICS users or non-ICS users in the mulitvariate models.

  • Image Result
    Flow chart of the EGEA population.

    Flow chart of the EGEA population.

 Supported by grants from Merck Sharp & Dohme (MSD); Hospital program of clinical research (PHRC)-Paris; National Research Agency - Health environment, health-work program; National Research Agency (ANR)- Biological collections for health program; French Agency of health safety, environment and work (AFSSET) and the Isere committee against respiratory diseases (COMARES).

 Disclosure of potential conflict of interest: C. Pison has served as a consultant for GlaxoSmithKline, Boehringer Ingelheim France, AstraZeneca, Nutricia, Numico, and Actéllion and has received research support from AB Science. The rest of the authors have declared that they have no conflict of interest.

PII: S0091-6749(09)00879-3

doi: 10.1016/j.jaci.2009.06.010

The Journal of Allergy and Clinical Immunology
Volume 124, Issue 4 , Pages 681-687.e3 , October 2009

Article Tools

* Image Usage & Resolution