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The Journal of Allergy and Clinical Immunology
Volume 124, Issue 1
, Pages 3-20
, July 2009
Intestinal barrier function: Molecular regulation and disease pathogenesis
References
- . Restoration of barrier function in injured intestinal mucosa. Physiol Rev. 2007;87:545–564
- . Mucosal immunity and inflammation. V. Innate mechanisms of mucosal defense and repair: the best offense is a good defense. Am J Physiol Gastrointest Liver Physiol. 1999;277:G495–G499
- . Electrolyte transport in the mammalian colon: mechanisms and implications for disease. Physiol Rev. 2002;82:245–289
- . Amino acid transport across mammalian intestinal and renal epithelia. Physiol Rev. 2008;88:249–286
- . Regulation of intestinal sugar transport. Physiol Rev. 1997;77:257–302
- . Multifunctional strands in tight junctions. Nat Rev Mol Cell Biol. 2001;2:285–293
- . Claudins and epithelial paracellular transport. Annu Rev Physiol. 2006;68:403–429
- . Junctional complexes in various epithelia. J Cell Biol. 1963;17:375–412
- . Structure, function, and regulation of cellular tight junctions. Am J Physiol Lung Cell Mol Physiol. 1992;262:L647–L661
- . Breaking through the tight junction barrier. J Cell Biol. 1993;123:1631–1633
- . Adherens and tight junctions: structure, function and connections to the actin cytoskeleton. Biochim Biophys Acta. 2008;1778:660–669
- . Tight junctions and the modulation of barrier function in disease. Histochem Cell Biol. 2008;130:55–70
- . Regulation of tight junction and loss of barrier function in pathophysiology. Int J Biochem Cell Biol. 2004;36:1206–1237
- . The structure and function of claudins, cell adhesion molecules at tight junctions. Ann N Y Acad Sci. 2000;915:129–135
- . Cell adhesion, polarity and epithelia in the dawn of metazoans. Physiol Rev. 2004;84:1229–1262
- . Re-solving the cadherin-catenin-actin conundrum. J Biol Chem. 2006;281:35593–35597
- . Cadherins in development: cell adhesion, sorting, and tissue morphogenesis. Genes Dev. 2006;20:3199–3214
- . Catenins: keeping cells from getting their signals crossed. Dev Cell. 2006;11:601–612
- . Sticky business: orchestrating cellular signals at adherens junctions. Cell. 2003;112:535–548
- . Regulation of cadherin-mediated adhesion in morphogenesis. Nat Rev Mol Cell Biol. 2005;6:622–634
- . Organization of multiprotein complexes at cell-cell junctions. Histochem Cell Biol. 2008;130:1–20
- . Directed actin polymerization is the driving force for epithelial cell-cell adhesion. Cell. 2000;100:209–219
- . Desmoplakin is essential in epidermal sheet formation. Nat Cell Biol. 2001;3:1076–1085
- Afadin: a key molecule essential for structural organization of cell-cell junctions of polarized epithelia during embryogenesis. J Cell Biol. 1999;146:1117–1132
- . The cytoplasmic face of cell contact sites. Curr Opin Struct Biol. 2002;12:255–262
- . Structure and mechanism of cadherins and catenins in cell-cell contacts. Annu Rev Cell Dev Biol. 2007;23:237–261
- . Emerging roles for p120-catenin in cell adhesion and cancer. Oncogene. 2004;23:7947–7956
- . In vivo analysis of cadherin function in the mouse intestinal epithelium: essential roles in adhesion, maintenance of differentiation, and regulation of programmed cell death. J Cell Biol. 1995;129:489–506
- . Inflammatory bowel disease and adenomas in mice expressing a dominant negative N-cadherin. Science. 1995;270:1203–1207
- . Nectin and nectin-like molecules: biology and pathology. Am J Nephrol. 2007;27:590–604
- . The immunoglobulin-like cell adhesion molecule nectin and its associated protein afadin. Annu Rev Cell Dev Biol. 2008;24:309–342
- . The roles of nectins in cell adhesions: cooperation with other cell adhesion molecules and growth factor receptors. Curr Opin Cell Biol. 2007;19:593–602
- . Biochemical and structural definition of the l-afadin- and actin-binding sites of alpha-catenin. J Biol Chem. 2002;277:18868–18874
- Two cell adhesion molecules, nectin and cadherin, interact through their cytoplasmic domain-associated proteins. J Cell Biol. 2000;150:1161–1176
- Ponsin/SH3P12: an l-afadin- and vinculin-binding protein localized at cell-cell and cell-matrix adherens junctions. J Cell Biol. 1999;144:1001–1017
- ADIP, a novel Afadin- and alpha-actinin-binding protein localized at cell-cell adherens junctions. J Biol Chem. 2003;278:4103–4111
- . Involvement of LMO7 in the association of two cell-cell adhesion molecules, nectin and E-cadherin, through afadin and alpha-actinin in epithelial cells. J Biol Chem. 2004;279:31365–31373
- . Tight junction proteins. Prog Biophys Mol Biol. 2003;81:1–44
- . Further observations on the fine structure of freeze-cleaved tight junctions. J Cell Sci. 1973;13:763–786
- . Epithelial tight junctions, gene expression and nucleojunctional interplay. J Cell Sci. 2007;120:1505–1511
- . Regulation of the intestinal epithelial barrier by the apical junctional complex. Curr Opin Gastroenterol. 2006;22:85–89
- Occludin-deficient embryonic stem cells can differentiate into polarized epithelial cells bearing tight junctions. J Cell Biol. 1998;141:397–408
- Epithelial transport and barrier function in occludin-deficient mice. Biochim Biophys Acta. 2005;1669:34–42
- Claudin-based tight junctions are crucial for the mammalian epidermal barrier: a lesson from claudin-1-deficient mice. J Cell Biol. 2002;156:1099–1111
- . Permeability barrier dysfunction in transgenic mice overexpressing claudin 6. Development. 2002;129:1775–1784
- JAM-A regulates permeability and inflammation in the intestine in vivo. J Exp Med. 2007;204:3067–3076
- Role of STAT6 and mast cells in IL-4- and IL-13-induced alterations in murine intestinal epithelial cell function. J Immunol. 2002;169:4417–4422
- . Interleukin-10 gene-deficient mice develop a primary intestinal permeability defect in response to enteric microflora. Inflamm Bowel Dis. 1999;5:262–270
- . Reducing small intestinal permeability attenuates colitis in the IL10 gene-deficient mouse. Gut. 2009;58:41–48
- . Interleukin-10-deficient mice develop chronic enterocolitis. Cell. 1993;75:263–274
- . Mast cells disrupt epithelial barrier function during enteric nematode infection. Proc Natl Acad Sci U S A. 2003;100:7761–7766
- IL-9- and mast cell-mediated intestinal permeability predisposes to oral antigen hypersensitivity. J Exp Med. 2008;205:897–913
- Targeted epithelial tight junction dysfunction causes immune activation and contributes to development of experimental colitis. Gastroenterology. 2009;136:551–563
- . Role of protein tyrosine phosphorylation in acetaldehyde-induced disruption of epithelial tight junctions. Am J Physiol Gastrointest Liver Physiol. 2001;280:G1280–G1288
- . L-Glutamine ameliorates acetaldehyde-induced increase in paracellular permeability in Caco-2 cell monolayer. Am J Physiol Gastrointest Liver Physiol. 2004;287:G510–G517
- Occludin: a novel integral membrane protein localizing at tight junctions. J Cell Biol. 1993;123:1777–1788
- Astrocytes and neurons express the tight junction-specific protein occludin in vitro. Exp Cell Res. 1999;250:434–438
- . Altered expression of retinal occludin and glial fibrillary acidic protein in experimental diabetes. The Penn State Retina Research Group. Invest Ophthalmol Vis Sci. 2000;41:3561–3568
- Dendritic cells express tight junction proteins and penetrate gut epithelial monolayers to sample bacteria. Nat Immunol. 2001;2:361–367
- Direct association of occludin with ZO-1 and its possible involvement in the localization of occludin at tight junctions. J Cell Biol. 1994;127:1617–1626
- . Molecular physiology and pathophysiology of tight junctions I. Tight junction structure and function: lessons from mutant animals and proteins. Am J Physiol Gastrointest Liver Physiol. 2000;279:G250–G254
- . Occludin 1B, a variant of the tight junction protein occludin. Mol Biol Cell. 2000;11:627–634
- Gene expression of the tight junction protein occludin includes differential splicing and alternative promoter usage. Biochem Biophys Res Commun. 2002;298:657–666
- . Functional dissociation of paracellular permeability and transepithelial electrical resistance and disruption of the apical-basolateral intramembrane diffusion barrier by expression of a mutant tight junction membrane protein. J Cell Biol. 1996;134:1031–1049
- Occludin is a functional component of the tight junction. J Cell Sci. 1996;109(suppl):2287–2298
- Der p 1 facilitates transepithelial allergen delivery by disruption of tight junctions. J Clin Invest. 1999;104:123–133
- . Hydrocortisone decreases retinal endothelial cell water and solute flux coincident with increased content and decreased phosphorylation of occludin. J Neurochem. 2002;80:667–677
- . Overexpression of occludin, a tight junction-associated integral membrane protein, induces the formation of intracellular multilamellar bodies bearing tight junction-like structures. J Cell Sci. 1996;109(suppl):429–435
- . Occludin confers adhesiveness when expressed in fibroblasts. J Cell Sci. 1997;110(suppl):1113–1121
- . Protein kinase C signaling regulates ZO-1 translocation and increased paracellular flux of T84 colonocytes exposed to Clostridium difficile toxin A. J Biol Chem. 2002;277:4247–4254
- . Protein phosphatase 2A associates with and regulates atypical PKC and the epithelial tight junction complex. J Cell Biol. 2002;158:967–978
- PKC eta regulates occludin phosphorylation and epithelial tight junction integrity. Proc Natl Acad Sci U S A. 2009;106:61–66
- . Regulation of tight junctions and loss of barrier function in pathophysiology. Int J Biochem Cell Biol. 2004;36:1206–1237
- . The tight junction: a multifunctional complex. Am J Physiol Cell Physiol. 2004;286:C1213–C1228
- . Barriers built on claudins. J Cell Sci. 2004;117:2435–2447
- . Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands. Proc Natl Acad Sci U S A. 1999;96:511–516
- . Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with the COOH termini of claudins. J Cell Biol. 1999;147:1351–1363
- Inducible expression of claudin-1-myc but not occludin-VSV-G results in aberrant tight junction strand formation in MDCK cells. J Cell Sci. 2000;113(suppl):3387–3398
- . Claudin-1 and -2: novel integral membrane proteins localizing at tight junctions with no sequence similarity to occludin. J Cell Biol. 1998;141:1539–1550
- . Junctional adhesion molecules (JAMs): more molecules with dual functions?. J Cell Sci. 2004;117:19–29
- . The JAM family of junctional adhesion molecules. Curr Opin Cell Biol. 2003;15:525–530
- . Identification and characterisation of human junctional adhesion molecule (JAM). Mol Immunol. 1999;36:1175–1188
- Human junction adhesion molecule regulates tight junction resealing in epithelia. J Cell Sci. 2000;113(suppl):2363–2374
- Homophilic interaction of junctional adhesion molecule. J Biol Chem. 2000;275:30970–30976
- Two regions of the human platelet F11-receptor (F11R) are critical for platelet aggregation, potentiation and adhesion. Thromb Haemost. 2002;87:712–721
- . Structure and function of claudins. Biochim Biophys Acta. 2008;1778:631–645
- . Manner of interaction of heterogeneous claudin species within and between tight junction strands. J Cell Biol. 1999;147:891–903
- . Conversion of zonulae occludentes from tight to leaky strand type by introducing claudin-2 into Madin-Darby canine kidney I cells. J Cell Biol. 2001;153:263–272
- . Claudin-8 expression in Madin-Darby canine kidney cells augments the paracellular barrier to cation permeation. J Biol Chem. 2003;278:17350–17359
- . Claudin extracellular domains determine paracellular charge selectivity and resistance but not tight junction fibril architecture. Am J Physiol Cell Physiol. 2003;284:C1346–C1354
- . Claudins create charge-selective channels in the paracellular pathway between epithelial cells. Am J Physiol Cell Physiol. 2002;283:C142–C147
- The density of small tight junction pores varies among cell types and is increased by expression of claudin-2. J Cell Sci. 2008;121:298–305
- . Claudin-3 and claudin-4 expression in ovarian epithelial cells enhances invasion and is associated with increased matrix metalloproteinase-2 activity. Cancer Res. 2005;65:7378–7385
- . Phosphorylation of claudin-3 at threonine 192 by cAMP-dependent protein kinase regulates tight junction barrier function in ovarian cancer cells. J Biol Chem. 2005;280:26233–26240
- . Phosphorylation of claudin-4 by PKCepsilon regulates tight junction barrier function in ovarian cancer cells. Exp Cell Res. 2007;313:3364–3375
- Disease-causing mutant WNK4 increases paracellular chloride permeability and phosphorylates claudins. Proc Natl Acad Sci U S A. 2004;101:4690–4694
- . Crosstalk of tight junction components with signaling pathways. Biochim Biophys Acta. 2008;1778:729–756
- Thr203 of claudin-1, a putative phosphorylation site for MAP kinase, is required to promote the barrier function of tight junctions. Exp Cell Res. 2004;295:36–47
- . The carboxyl terminus of zona occludens-3 binds and recruits a mammalian homologue of discs lost to tight junctions. J Biol Chem. 2002;277:27501–27509
- . Tight junctions: molecular architecture and function. Int Rev Cytol. 2006;248:261–298
- . Parsing the polarity code. Nat Rev Mol Cell Biol. 2004;5:220–231
- . Two splice variants of claudin-10 in the kidney create paracellular pores with different ion selectivities. Am J Physiol Renal Physiol. 2006;291:F1288–F1299
- . Increased gastrointestinal permeability is an early lesion in the spontaneously diabetic BB rat. Am J Physiol Gastrointest Liver Physiol. 1999;276:G951–G957
- . Tumour necrosis factor-alpha and interferon-gamma production measured at the single cell level in normal and inflamed human intestine. Clin Exp Immunol. 1990;81:301–305
- . Interferon expression in Crohn's disease patients: increased interferon-gamma and -alpha mRNA in the intestinal lamina propria mononuclear cells. J Interferon Res. 1994;14:235–238
- . Molecular mechanism of tumor necrosis factor-alpha modulation of intestinal epithelial tight junction barrier. Am J Physiol Gastrointest Liver Physiol. 2006;290:G496–G504
- A membrane-permeant peptide that inhibits MLC kinase restores barrier function in in vitro models of intestinal disease. Gastroenterology. 2002;123:163–172
- Expression from the human occludin promoter is affected by tumor necrosis factor alpha and interferon gamma. J Cell Sci. 2000;113(suppl):2085–2090
- . Interleukin-4 and interleukin-13 differentially regulate epithelial chloride secretion. J Biol Chem. 1996;271:7460–7464
- . Interleukins 4 and 13 increase intestinal epithelial permeability by a phosphatidylinositol 3-kinase pathway. Lack of evidence for STAT 6 involvement. J Biol Chem. 2000;275:29132–29137
- . Role for IL-4 in macromolecular transport across human intestinal epithelium. Am J Physiol Cell Physiol. 1999;276:C1046–C1052
- Inflammatory processes have differential effects on claudins 2, 3 and 4 in colonic epithelial cells. Lab Invest. 2005;85:1139–1162
- . Interleukin 10 modulates ion transport in rat small intestine. Gastroenterology. 1996;111:936–944
- . Interleukin 10 prevents cytokine-induced disruption of T84 monolayer barrier integrity and limits chloride secretion. Gastroenterology. 1997;113:151–159
- . Mechanisms of disease: the role of intestinal barrier function in the pathogenesis of gastrointestinal diseases. Nat Clin Pract Gastroenterol Hepatol. 2005;2:416–422
- T cell activation causes diarrhea by increasing intestinal permeability and inhibiting epithelial Na+/K+-ATPase. J Clin Invest. 2002;110:1739–1747
- Epithelial myosin light chain kinase-dependent barrier dysfunction mediates T cell activation-induced diarrhea in vivo. J Clin Invest. 2005;115:2702–2715
- . Coordinated epithelial NHE3 inhibition and barrier dysfunction are required for TNF-mediated diarrhea in vivo. J Clin Invest. 2006;116:2682–2694
- Intraepithelial gammadelta+ lymphocytes maintain the integrity of intestinal epithelial tight junctions in response to infection. Gastroenterology. 2006;131:818–829
- . Role of mast cells in intestinal mucosal function: studies in models of hypersensitivity and stress. Immunol Rev. 2001;179:61–73
- . Immunomodulatory mast cells: negative, as well as positive, regulators of immunity. Nat Rev Immunol. 2008;8:478–486
- . Human mast cells, bacteria, and intestinal immunity. Immunol Rev. 2007;217:329–337
- . Role of mast cells in allergic and non-allergic immune responses: comparison of human and murine data. Nat Rev Immunol. 2007;7:93–104
- . The mast cell and gut nematodes: damage and defence. Chem Immunol Allergy. 2006;90:128–140
- . Intestinal permeability in allergic rats: nerve involvement in antigen-induced changes. Am J Physiol Gastrointest Liver Physiol. 1993;264:G617–G6123
- . Role of mast cells in ion transport abnormalities associated with intestinal anaphylaxis. Correction of the diminished secretory response in genetically mast cell-deficient W/Wv mice by bone marrow transplantation. J Clin Invest. 1991;87:687–693
- . Rapid transepithelial antigen transport in rat jejunum: impact of sensitization and the hypersensitivity reaction. Gastroenterology. 1997;113:856–864
- . Allergic reactions of rat jejunal mucosa. Ion transport responses to luminal antigen and inflammatory mediators. Gastroenterology. 1990;99:74–82
- . Distribution and activation of eosinophils in inflammatory bowel disease using an improved immunohistochemical technique. J Pathol. 2001;194:484–492
- . Increased eosinophil granule proteins in gut lavage fluid from patients with inflammatory bowel disease. Mayo Clin Proc. 1997;72:117–123
- Immunohistochemical study of intestinal eosinophils in inflammatory bowel disease. J Clin Gastroenterol. 2003;36:120–125
- . Role of the intestinal barrier in inflammatory bowel disease. World J Gastroenterol. 2008;14:401–407
- Eosinophils alter colonic epithelial barrier function: role for major basic protein. Am J Physiol Gastrointest Liver Physiol. 2005;289:G890–G897
- . Alcohol and the gastrointestinal tract. Ergeb Inn Med Kinderheilkd. 1980;45:1–75
- . Acute exposure of small intestine to ethanol: effects on morphology and function. Dig Dis Sci. 1981;26:817–838
- Impairment of the intestinal barrier by ethanol involves enteric microflora and mast cell activation in rodents. Am J Pathol. 2006;168:1148–1154
- . Nitric oxide and its metabolites mediate ethanol-induced microtubule disruption and intestinal barrier dysfunction. J Pharmacol Exp Ther. 2000;294:997–1008
- . Prevention of alterations in intestinal permeability is involved in zinc inhibition of acute ethanol-induced liver damage in mice. J Pharmacol Exp Ther. 2003;305:880–886
- . Small intestinal damage and changes in cell population produced by ethanol ingestion in the rat. Gastroenterology. 1974;66:226–234
- . Endotoxin hepatotoxicity augmented by ethanol. Exp Mol Pathol. 1991;55:196–202
- . Long-term ethanol feeding enhances susceptibility of the liver to orally administered lipopolysaccharides in rats. Alcohol Clin Exp Res. 2002;26(suppl):75S–80S
- . Alcohol-induced gastric and duodenal lesions in man. Am J Gastroenterol. 1978;70:587–592
- . Increased intestinal permeability to macromolecules and endotoxemia in patients with chronic alcohol abuse in different stages of alcohol-induced liver disease. J Hepatol. 2000;32:742–747
- . Histamine is involved in ethanol-induced jejunal microvascular injury in rabbits. Gastroenterology. 1988;95:1227–1233
- . Role of xanthine oxidase-derived oxidants and leukocytes in ethanol-induced jejunal mucosal injury. Dig Dis Sci. 1996;41:2461–2470
- . An intestinal disease produced experimentally by a prostaglandin deficiency. Gastroenterology. 1975;69:1045–1047
- . Temporal relationship between cyclooxygenase inhibition, as measured by prostacyclin biosynthesis, and the gastrointestinal damage induced by indomethacin in the rat. Gastroenterology. 1981;80:94–98
- Nonsteroidal antiinflammatory drug-induced intestinal inflammation in humans. Gastroenterology. 1987;93:480–489
- . Nonsteroidal anti-inflammatory drugs activate quiescent inflammatory bowel disease. Ann Intern Med. 1987;107:513–516
- . Toward an epidemiology of gastropathy associated with nonsteroidal antiinflammatory drug use. Gastroenterology. 1989;96:647–655
- . Objective evidence of aspirin use in both ulcer and nonulcer upper and lower gastrointestinal bleeding. Gastroenterology. 1992;103:862–869
- Risks of bleeding peptic ulcer associated with individual non-steroidal anti-inflammatory drugs. Lancet. 1994;343:1075–1078
- . Evidence of aspirin use in both upper and lower gastrointestinal perforation. Gastroenterology. 1997;112:683–689
- Comparison of indomethacin and nimesulide, a selective cyclooxygenase-2 inhibitor, on key pathophysiologic steps in the pathogenesis of nonsteroidal anti-inflammatory drug enteropathy in the rat. Scand J Gastroenterol. 1998;33:728–735
- Intestinal permeability and inflammation in patients on NSAIDs. Gut. 1998;43:506–511
- . Aspirin induces gastric epithelial barrier dysfunction by activating p38 MAPK via claudin-7. Am J Physiol Cell Physiol. 2008;295:C800–C806
- . The effects of 16,16-dimethyl prostaglandin E2 + aspirin on the canine gastric mucosal barrier. Virchows Arch A Pathol Anat Histopathol. 1987;412:119–125
- . Gastric ulceration induced by nonsteroidal anti-inflammatory drugs is a neutrophil-dependent process. Am J Physiol Gatrointest Liver Physiol. 1990;259:G462–G467
- . Oxygen free radicals and lipid peroxidation in the pathogenesis of gastric mucosal lesions induced by indomethacin in rats. Relation to gastric hypermotility. Digestion. 1991;49:175–184
- . Dual action of nitric oxide in pathogenesis of indomethacin-induced small intestinal ulceration in rats. J Physiol Pharmacol. 1999;50:405–417
- Uncoupling of intestinal mitochondrial oxidative phosphorylation and inhibition of cyclooxygenase are required for the development of NSAID-enteropathy in the rat. Aliment Pharmacol Ther. 2000;14:639–650
- . Intestinal epithelial responses to enteric pathogens: effects on the tight junction barrier, ion transport, and inflammation. Gut. 2003;52:439–451
- . Vibrio cholerae hemagglutinin/protease (HA/protease) causes morphological changes in cultured epithelial cells and perturbs their paracellular barrier function. Microb Pathog. 1996;21:111–123
- . Association of protease activity in Vibrio cholerae vaccine strains with decreases in transcellular epithelial resistance of polarized T84 intestinal epithelial cells. Infect Immun. 2000;68:6487–6492
- . Distinct effects of Vibrio cholerae haemagglutinin/protease on the structure and localization of the tight junction-associated proteins occludin and ZO-1. Cell Microbiol. 2000;2:11–17
- Vibrio cholerae produces a second enterotoxin, which affects intestinal tight junctions. Proc Natl Acad Sci U S A. 1991;88:5242–5246
- Zonula occludens toxin modulates tight junctions through protein kinase C-dependent actin reorganization, in vitro. J Clin Invest. 1995;96:710–720
- . Tight junction modulation and biochemical characterisation of the zonula occludens toxin C- and N-termini. FEBS Lett. 2007;581:2974–2980
- . The enterotoxic effect of zonula occludens toxin on rabbit small intestine involves the paracellular pathway. Gastroenterology. 1997;112:839–846
- . Human zonulin, a potential modulator of intestinal tight junctions. J Cell Sci. 2000;113(suppl):4435–4440
- . Adhesion of enteropathogenic Escherichia coli to human intestinal enterocytes and cultured human intestinal mucosa. Infect Immun. 1987;55:69–77
- . Enteropathogenic Escherichia coli contains a putative type III secretion system necessary for the export of proteins involved in attaching and effacing lesion formation. Proc Natl Acad Sci U S A. 1995;92:7996–8000
- . Enteropathogenic Escherichia coli adherence to intestinal epithelial monolayers diminishes barrier function. Am J Physiol Gastrointest Liver Physiol. 1995;268:G374–G379
- . Enteropathogenic Escherichia coli infection leads to appearance of aberrant tight junctions strands in the lateral membrane of intestinal epithelial cells. Cell Microbiol. 2004;6:783–793
- . Infection of T84 cells with enteropathogenic Escherichia coli alters barrier and transport functions. Am J Physiol Gastrointest Liver Physiol. 1996;270:G634–G645
- . Enteropathogenic Escherichia coli-induced myosin light chain phosphorylation alters intestinal epithelial permeability. Gastroenterology. 1997;113:1873–1882
- . Clostridium perfringens enterotoxin binds to the second extracellular loop of claudin-3, a tight junction integral membrane protein. FEBS Lett. 2000;476:258–261
- . Clostridium perfringens enterotoxin utilizes two structurally related membrane proteins as functional receptors in vivo. J Biol Chem. 1997;272:26652–26658
- . Comparative biochemical and immunocytochemical studies reveal differences in the effects of Clostridium perfringens enterotoxin on polarized CaCo-2 cells versus Vero cells. J Biol Chem. 2001;276:33402–33412
- . CaCo-2 cells treated with Clostridium perfringens enterotoxin form multiple large complex species, one of which contains the tight junction protein occludin. J Biol Chem. 2000;275:18407–18417
- Clostridium perfringens enterotoxin fragment removes specific claudins from tight junction strands: Evidence for direct involvement of claudins in tight junction barrier. J Cell Biol. 1999;147:195–204
- . The importance of calcium influx, calpain and calmodulin for the activation of CaCo-2 cell death pathways by Clostridium perfringens enterotoxin. Cell Microbiol. 2005;7:129–146
- . Death pathways activated in CaCo-2 cells by Clostridium perfringens enterotoxin. Infect Immun. 2003;71:4260–4270
- . The significance of the gut barrier in disease. Gut. 2008;57:438–440
- Genetic basis for increased intestinal permeability in families with Crohn's disease: role of CARD15 3020insC mutation?. Gut. 2006;55:342–347
- . Genetic aspects of intestinal permeability in inflammatory bowel disease. In: Chadwick D, Goode J editor. Inflammatory bowel disease-crossroads of microbes, epithelium and immune systems. Chichester: Wiley; 2004;p. 151–163
- . Altered permeability in inflammatory bowel disease: pathophysiology and clinical implications. Curr Opin Gastroenterol. 2007;23:379–383
- . Cytokine-induced alteration of the epithelial barrier to food antigens in disease. Ann N Y Acad Sci. 2003;202:304–311
- . Gut barrier dysfunction in food allergy. Eur J Gastroenterol Hepatol. 2005;17:1279–1285
- . Measurement of intestinal permeability to mannitol and lactulose as a means of diagnosing food allergy and evaluating therapeutic effectiveness of disodium cromoglycate. Ann Allergy. 1987;59:127–130
- Tumor necrosis factor alpha antibody (infliximab) therapy profoundly down-regulates the inflammation in Crohn's ileocolitis. Gastroenterology. 1999;116:22–28
- Anti-tumor necrosis factor treatment restores the gut barrier in Crohn's disease. Am J Gastroenterol. 2002;97:2000–2004
- Gliadin, zonulin and gut permeability: effects on celiac and non-celiac intestinal mucosa and intestinal cell lines. Scand J Gastroenterol. 2006;41:408–419
- Zonulin, a newly discovered modulator of intestinal permeability, and its expression in coeliac disease. Lancet. 2000;355:1518–1519
- Role of the intestinal tight junction modulator zonulin in the pathogenesis of type I diabetes in BB diabetic-prone rats. Proc Natl Acad Sci U S A. 2005;102:2916–2921
- Zonulin upregulation is associated with increased gut permeability in subjects with type 1 diabetes and their relatives. Diabetes. 2006;55:1443–1449
- . Effect of stress on the paracellular barrier in the rat ileum. Gut. 2002;51:507–513
- Corticotropin-releasing hormone mimics stress-induced colonic epithelial pathophysiology in the rat. Am J Physiol Gastrointest Liver Physiol. 1999;277:G391–G399
- Characterisation of immune mediator release during the immediate response to segmental mucosal challenge in the jejunum of patients with food allergy. Gut. 1999;45:553–558
- . Chronic stress impairs rat growth and jejunal epithelial barrier function: role of mast cells. Am J Physiol Gastrointest Liver Physiol. 2000;278:G847–G854
- . Colonic mucin release in response to immobilization stress is mast cell dependent. Am J Physiol Gastrointest Liver Physiol. 1998;274:G1094–G1100
- . In vitro determination of small intestinal permeability: demonstration of a persistent defect in patients with coeliac disease. Gut. 1984;25:145–150
- . Epithelial tight junction structure in the jejunum of children with acute and treated celiac sprue. Pediatr Res. 1998;43:435–441
- . Intestinal permeability and the prediction of relapse in Crohn's disease. Lancet. 1993;341:1437–1439
- Intestinal permeability test as a predictor of clinical course in Crohn's disease. Am J Gastroenterol. 1999;94:2956–2960
- Intestinal permeability in patients with adverse reactions to food. Dig Liver Dis. 2006;38:732–736
- . The intestinal permeability test applied to the diagnosis of food allergy in pediatrics. West Indian Med J. 1994;43:87–88
- . Life-threatening food allergy in a child treated with FK506. J Pediatr Gastroenterol Nutr. 1997;25:228–229
- . Experience of FK506 immune suppression in pediatric heart transplantation: a study of long-term adverse effects. J Heart Lung Transplant. 1996;15:415–422
- . Tacrolimus immunosuppression—an association with asymptomatic eosinophilia and elevated total and specific IgE levels. Pediatr Transplant. 2006;10:690–693
- Gastrointestinal toxicity associated with FK 506 in liver transplant recipients. Transplant Proc. 1994;26:3106–3107
- The effect of tacrolimus (FK506) on intestinal barrier function and cellular energy production in humans. Gastroenterology. 1998;115:67–74
- . The development of food allergy after liver transplantation. Liver Transpl. 2005;11:326–330
- Transfer of symptomatic peanut allergy to the recipient of a combined liver-and-kidney transplant. N Engl J Med. 1997;337:822–824
- . De novo food allergy after intestinal transplantation: a report of three cases. J Pediatr Gastroenterol Nutr. 2004;38:545–547
- . Development of multiple food allergies in children taking tacrolimus after heart and liver transplantation. Pediatr Transplant. 2006;10:380–383
- . FK506 increases permeability in rat intestine by inhibiting mitochondrial function. Gastroenterology. 1995;109:107–114
- . The movement of solutes and cells across tight junctions. Ann N Y Acad Sci. 1992;664:47–60
- . Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes. Cell. 1991;66:807–815
- . Abnormal permeability precedes the development of a gluten sensitive enteropathy in Irish setter dogs. Gut. 1991;32:749–753
- . A murine model of IgE-mediated cow's milk hypersensitivity. J Allergy Clin Immunol. 1999;103:206–214
- Mast cells are required for experimental oral allergen-induced diarrhea. J Clin Invest. 2003;112:1666–1677
- . The influence of mast cells on pathways of transepithelial antigen transport in rat intestine. J Immunol. 1998;161:2561–2566
- . A porous defense: the leaky epithelial barrier in intestinal disease. Lab Invest. 2004;84:282–291
- Intestinal permeability in Crohn's disease patients and their first degree relatives. Dig Liver Dis. 2001;33:680–685
- Different intestinal permeability patterns in relatives and spouses of patients with Crohn's disease: an inherited defect in mucosal defence?. Gut. 1999;44:96–100
- Clustering of increased small intestinal permeability in families with Crohn's disease. Gastroenterology. 1997;113:802–807
- . Intestinal permeability changes in response to acetylsalicylic acid in relatives of patients with Crohn's disease. Gastroenterology. 1996;110:1395–1403
- . Increased intestinal permeability precedes the onset of Crohn's disease in a subject with familial risk. Gastroenterology. 2000;119:1740–1744
- The primary defect in experimental ileitis originates from a nonhematopoietic source. J Exp Med. 2006;203:541–552
- . Epithelial dysfunction associated with the development of colitis in conventionally housed mdr1a-/- mice. Am J Physiol Gastrointest Liver Physiol. 2005;289:G153–G162
- Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease. Nature. 2001;411:599–603
- A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease. Nature. 2001;411:603–606
- . Leaks in the epithelial barrier caused by spontaneous and TNF-alpha-induced single-cell apoptosis. FASEB J. 2000;14:1749–1753
- . Neutrophil transmigration in inflammatory bowel disease is associated with differential expression of epithelial intercellular junction proteins. Am J Pathol. 2001;159:2001–2009
- Changes in expression and distribution of claudin 2, 5 and 8 lead to discontinuous tight junctions and barrier dysfunction in active Crohn's disease. Gut. 2007;56:61–72
- . Interferon-gamma directly affects barrier function of cultured intestinal epithelial monolayers. J Clin Invest. 1989;83:724–727
- . Modulation of tumor necrosis factor-induced increase in renal (LLC-PK1) transepithelial permeability. Am J Physiol. 1992;263:F915–F924
- . Structural abnormalities of jejunal epithelial cell membranes in celiac sprue. Lab Invest. 1980;43:254–261
- Gastrointestinal permeability in celiac disease. Gastroenterology. 1997;112:1129–1136
- . Intestinal permeability in patients with coeliac disease and relatives of patients with coeliac disease. Gut. 1993;34:354–357
- . Morphological and biochemical studies of a naturally occurring enteropathy in the Irish setter dog: a comparison with coeliac disease in man. Res Vet Sci. 1984;37:339–346
- Gliadin induces an increase in intestinal permeability and zonulin release by binding to the chemokine receptor CXCR3. Gastroenterology. 2008;135:194–204e3
- Early effects of gliadin on enterocyte intracellular signalling involved in intestinal barrier function. Gut. 2003;52:218–223
- . Immunohistochemical analysis of ZO-1 in the duodenal mucosa of patients with untreated and treated celiac disease. Digestion. 2002;65:227–233
- Transcriptional downregulation of tight junction protein ZO-1 in active coeliac disease is reversed after a gluten-free diet. Dig Liver Dis. 2004;36:337–341
- . Genetic background of celiac disease and its clinical implications. Am J Gastroenterol. 2008;103:190–195
- . Abnormal intestinal permeability to sugars in diabetes mellitus. Diabetologia. 1986;29:221–224
- Altered intestinal permeability to mannitol in diabetes mellitus type I. J Pediatr Gastroenterol Nutr. 1999;28:264–269
- Intestinal permeability assessment before and after ileal pouch-anal anastomosis. Minerva Gastroenterol Dietol. 2004;50:155–163
- Ultrastructural mucosal alterations and increased intestinal permeability in non-celiac, type I diabetic patients. Dig Liver Dis. 2004;36:35–45
- Changes in intestinal morphology and permeability in the biobreeding rat before the onset of type 1 diabetes. J Pediatr Gastroenterol Nutr. 2005;40:589–595
- . Acute stressors stimulate ion secretion and increase epithelial permeability in rat intestine. Am J Physiol Gastrointest Liver Physiol. 1994;267:G794–G799
- Stress stimulates transepithelial macromolecular uptake in rat jejunum. Am J Physiol Gastrointest Liver Physiol. 1998;275:G1037–G1044
- Stress and exacerbation in ulcerative colitis: a prospective study of patients enrolled in remission. Am J Gastroenterol. 2000;95:1213–1220
- . Stress and the gastrointestinal tract IV. Modulation of intestinal inflammation by stress: basic mechanisms and clinical relevance. Am J Physiol Gastrointest Liver Physiol. 2001;280:G315–G318
- . Psychosocial aspects of Crohn's disease. Surg Clin North Am. 2001;81:231–252x
- . Susceptibility of Lewis and Fischer rats to stress-induced worsening of TNB-colitis: protective role of brain CRF. Am J Physiol Gastrintest Liver Physiol. 1999;276:G1027–G1036
- . The role of CD4+ lymphocytes in the susceptibility of mice to stress-induced reactivation of experimental colitis. Nat Med. 1999;5:1178–1182
- . Level of chronic life stress predicts clinical outcome in irritable bowel syndrome. Gut. 1998;43:256–261
Series editors: Donald Y. M. Leung, MD, PhD, and Dennis K. Ledford, MD
Supported in part by a Crohn's Colitis Foundation of America Career Development Award, an American Heart Association Grant-in-Aid, and National Institutes of Health grants R01 (AI 073553), F30 (DK082113), and T32 (GM063483).
PII: S0091-6749(09)00864-1
doi: 10.1016/j.jaci.2009.05.038
© 2009 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.
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The Journal of Allergy and Clinical Immunology
Volume 124, Issue 1
, Pages 3-20
, July 2009
