The Journal of Allergy and Clinical Immunology
Volume 124, Issue 2 , Pages 207-212 , August 2009

Does higher body mass index contribute to worse asthma control in an urban population?

  • Emmanuelle M. Clerisme-Beaty, MD, MHS

      Affiliations

    • Department of Medicine, Johns Hopkins University, Baltimore, Md
    • These authors contributed equally to this work.
  • ,
  • Sabine Karam, MD

      Affiliations

    • Department of Medicine, Albert Einstein College of Medicine, New York, NY
    • These authors contributed equally to this work.
  • ,
  • Cynthia Rand, PhD

      Affiliations

    • Department of Medicine, Johns Hopkins University, Baltimore, Md
  • ,
  • Cecilia M. Patino, MD

      Affiliations

    • Department of Preventive Medicine, University of Southern California, Los Angeles, Calif
  • ,
  • Andrew Bilderback, MS

      Affiliations

    • Department of Medicine, Johns Hopkins University, Baltimore, Md
  • ,
  • Kristin A. Riekert, PhD

      Affiliations

    • Department of Medicine, Johns Hopkins University, Baltimore, Md
  • ,
  • Sande O. Okelo, MD

      Affiliations

    • Department of Pediatrics, Johns Hopkins University, Baltimore, Md
  • ,
  • Gregory B. Diette, MD, MHS

      Affiliations

    • Department of Medicine, Johns Hopkins University, Baltimore, Md
    • Corresponding Author InformationReprint requests: Gregory B. Diette, MD, MHS, Division of Pulmonary Critical Care Medicine, 1830 E Monument St, Fifth Floor, Baltimore, MD 21205.

Received 19 December 2008 ,Revised 12 May 2009 ,Accepted 15 May 2009.

References 

  1. Arif AA, Delclos GL, Lee ES, Tortolero SR, Whitehead LW. Prevalence and risk factors of asthma and wheezing among US adults: an analysis of the NHANES III data. Eur Respir J. 2003;21:827–833
  2. Ford ES. The epidemiology of obesity and asthma. J Allergy Clin Immunol. 2005;115:897–909
  3. Ford ES, Mannino DM. Time trends in obesity among adults with asthma in the United States: findings from three national surveys. J Asthma. 2005;42:91–95
  4. Hedley AA, Ogden CL, Johnson CL, Carroll MD, Curtin LR, Flegal KM. Prevalence of overweight and obesity among US children, adolescents, and adults, 1999-2002. JAMA. 2004;291:2847–2850
  5. Ogden CL, Carroll MD, Curtin LR, McDowell MA, Tabak CJ, Flegal KM. Prevalence of overweight and obesity in the United States, 1999-2004. JAMA. 2006;295:1549–1555
  6. Rhodes L, Bailey CM, Moorman JE. Asthma prevalence and control characteristics by race/ethnicity—United States, 2002. Report. National Center for Environmental Health, Center for Disease Control. 2004:145-8.
  7. Moorman JE, Rudd RA, Johnson CA, King M, Minor P, Bailey C, et al. National surveillance for asthma—United States, 1980-2004. MMWR Surveill Summ. 2007;56:1–54
  8. Beuther DA, Sutherland ER. Overweight, obesity, and incident asthma: a meta-analysis of prospective epidemiologic studies. Am J Respir Crit Care Med. 2007;175:661–666
  9. Litonjua AA, Sparrow D, Celedon JC, DeMolles D, Weiss ST. Association of body mass index with the development of methacholine airway hyperresponsiveness in men: the Normative Aging Study. Thorax. 2002;57:581–585
  10. Tantisira KG, Litonjua AA, Weiss ST, Fuhlbrigge AL. Association of body mass with pulmonary function in the Childhood Asthma Management Program (CAMP). Thorax. 2003;58:1036–1041
  11. Sin DD, Jones RL, Man SF. Obesity is a risk factor for dyspnea but not for airflow obstruction. Arch Intern Med. 2002;162:1477–1481
  12. Hakala K, Stenius-Aarniala B, Sovijarvi A. Effects of weight loss on peak flow variability, airways obstruction, and lung volumes in obese patients with asthma. Chest. 2000;118:1315–1321
  13. Jones RL, Nzekwu MM. The effects of body mass index on lung volumes. Chest. 2006;130:827–833
  14. Shore SA. Obesity and asthma: possible mechanisms. J Allergy Clin Immunol. 2008;121:1087–1093
  15. Akerman MJ, Calacanis CM, Madsen MK. Relationship between asthma severity and obesity. J Asthma. 2004;41:521–526
  16. Taylor B, Mannino D, Brown C, Crocker D, Twum-Baah N, Holguin F. Body mass index and asthma severity in the National Asthma Survey. Thorax. 2008;63:14–20
  17. Mosen DM, Schatz M, Magid DJ, Camargo CA. The relationship between obesity and asthma severity and control in adults. J Allergy Clin Immunol. 2008;122:507–511
  18. Juniper EF, O'Byrne PM, Guyatt GH, Ferrie PJ, King DR. Development and validation of a questionnaire to measure asthma control. Eur Respir J. 1999;14:902–907
  19. Vollmer WM, Markson LE, O'Connor E, Sanocki LL, Fitterman L, Berger M, et al. Association of asthma control with health care utilization and quality of life. Am J Respir Crit Care Med. 1999;160:1647–1652
  20. Vollmer WM, Markson LE, O'Connor E, Frazier EA, Berger M, Buist AS. Association of asthma control with health care utilization: a prospective evaluation. Am J Respir Crit Care Med. 2002;165:195–199
  21. National Heart, Lung, and Blood Institute. Expert panel report 3: guidelines for the diagnosis and management of asthma—full report 2007, p 36. Available at: http://www.nhlbi.nih.gov/guidelines/asthma. 2007. Accessed December 3, 2008.
  22. Peters D, Chen C, Markson LE, Allen-Ramey FC, Vollmer WM. Using an asthma control questionnaire and administrative data to predict health-care utilization. Chest. 2006;129:918–924
  23. Patino CM, Okelo SO, Rand CS, Riekert KA, Krishnan JA, Thompson K, et al. The Asthma Control and Communication Instrument: a clinical tool developed for ethnically diverse populations. J Allergy Clin Immunol. 2008;122:936–943
  24. National Heart, Lung, and Blood Institute. Expert Panel Report: guidelines for the diagnosis and management of asthma: update on selected topics 2002. Available at: http://www.nhlbi.nih.gov/guidelines/archives/epr-2_upd. Accessed December 5, 2008.
  25. Schatz M, Mosen DM, Kosinski M, Vollmer WM, Magid DJ, O'Connor E, et al. The relationship between asthma-specific quality of life and asthma control. J Asthma. 2007;44:391–395
  26. Juniper EF, Svensson K, Mork AC, Stahl E. Measurement properties and interpretation of three shortened versions of the asthma control questionnaire. Respir Med. 2005;99:553–558
  27. ARRD. Lung-function testing: selection of reference values and interpretative strategies. Am Rev Respir Dis. 1991;144:1202–1218
  28. Hankinson JL, Odencrantz JR, Fedan KB. Spirometric reference values from a sample of the general U.S. population. Am J Respir Crit Care Med. 1999;159:179–187
  29. NHLBI. Classification and risks of overweight and obesity. Available at: http://www.nhlbi.nih.gov/health/public/heart/obesity/lose_wt/bmi_dis.htm. Accessed December 17, 2008.
  30. Kuczmarski MF, Kuczmarski RJ, Najjar M. Effects of age on validity of self-reported height, weight, and body mass index: findings from the Third National Health and Nutrition Examination Survey, 1988-1994. J Am Diet Assoc. 2001;101:28–34
  31. Lavoie KL, Bacon SL, Labrecque M, Cartier A, Ditto B. Higher BMI is associated with worse asthma control and quality of life but not asthma severity. Respir Med. 2006;100:648–657
  32. Thomson CC, Clark S, Camargo CA. MARC Investigators. Body mass index and asthma severity among adults presenting to the emergency department. Chest. 2003;124:795–802
  33. Pelegrino NR, Faganello MM, Sanchez FF, Padovani CR, Godoy I. Relationship between body mass index and asthma severity in adults. J Bras Pneumol. 2007;33:641–646
  34. Leung TF, Li CY, Lam CW, Au CS, Yung E, Chan IH, et al. The relation between obesity and asthmatic airway inflammation. Pediatr Allergy Immunol. 2004;15:344–350
  35. McLachlan CR, Poulton R, Car G, Cowan J, Filsell S, Greene JM, et al. Adiposity, asthma, and airway inflammation. J Allergy Clin Immunol. 2007;119:634–639
  36. Todd DC, Armstrong S, D'Silva L, Allen CJ, Hargreave FE, Parameswaran K. Effect of obesity on airway inflammation: a cross-sectional analysis of body mass index and sputum cell counts. Clin Exp Allergy. 2007;37:1049–1054
  37. Schatz M, Sorkness CA, Li JT, Marcus P, Murray JJ, Nathan RA, et al. Asthma Control Test: reliability, validity, and responsiveness in patients not previously followed by asthma specialists. J Allergy Clin Immunol. 2006;117:549–556
  38. Mancuso CA, Wenderoth S, Westermann H, Choi TN, Briggs WM, Charlson ME. Patient-reported and physician-reported depressive conditions in relation to asthma severity and control. Chest. 2008;133:1142–1148
  39. Williams LK, Pladevall M, Xi H, Peterson EL, Joseph C, Lafata JE, et al. Relationship between adherence to inhaled corticosteroids and poor outcomes among adults with asthma. J Allergy Clin Immunol. 2004;114:1288–1293
  40. Mannino DM, Homa DM, Akinbami LJ, Moorman JE, Gwynn C, Redd SC. Surveillance for asthma—United States, 1980-1999. MMWR Surveill Summ. 2002;51:1–13
  41. Trochtenberg DS, BeLue R, Piphus S, Washington N. Differing reports of asthma symptoms in African Americans and Caucasians. J Asthma. 2008;45:165–170

 Supported by National Heart, Lung, and Blood Institute grant 5UO1HL072455 and National Institutes of Health grant K12 RR017627.

 Disclosure of potential conflict of interest: C. Rand is a consultant for Schering-Plough and the Merck Foundation. The rest of the authors have declared that they have no conflict of interest.

PII: S0091-6749(09)00858-6

doi: 10.1016/j.jaci.2009.05.034

The Journal of Allergy and Clinical Immunology
Volume 124, Issue 2 , Pages 207-212 , August 2009