The Journal of Allergy and Clinical Immunology
Volume 124, Issue 2 , Pages 222-229 , August 2009

A thymic stromal lymphopoietin gene variant is associated with asthma and airway hyperresponsiveness

  • Jian-Qing He, MD

      Affiliations

    • James Hogg Imaging, Cell Analysis, and Phenotyping Toward Understanding Responsive, Reparative, Remodelling, and Recombinant Events (iCAPTURE) Centre, University of British Columbia, Vancouver, British Columbia, Canada
    • ,
  • Teal S. Hallstrand, MD, MPH

      Affiliations

    • Department of Medicine, Division of Pulmonary and Critical Care, University of Washington, Seattle, Wash
    • ,
  • Darryl Knight, PhD

      Affiliations

    • James Hogg Imaging, Cell Analysis, and Phenotyping Toward Understanding Responsive, Reparative, Remodelling, and Recombinant Events (iCAPTURE) Centre, University of British Columbia, Vancouver, British Columbia, Canada
    • Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, British Columbia, Canada
    • ,
  • Moira Chan-Yeung, MD

      Affiliations

    • Occupational and Environmental Lung Disease Unit, University of British Columbia, Vancouver, British Columbia, Canada
    • ,
  • Andrew Sandford, PhD

      Affiliations

    • James Hogg Imaging, Cell Analysis, and Phenotyping Toward Understanding Responsive, Reparative, Remodelling, and Recombinant Events (iCAPTURE) Centre, University of British Columbia, Vancouver, British Columbia, Canada
    • Division of Respiratory Medicine, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada
    • ,
  • Ben Tripp, BSs

      Affiliations

    • James Hogg Imaging, Cell Analysis, and Phenotyping Toward Understanding Responsive, Reparative, Remodelling, and Recombinant Events (iCAPTURE) Centre, University of British Columbia, Vancouver, British Columbia, Canada
    • ,
  • David Zamar, MSc

      Affiliations

    • James Hogg Imaging, Cell Analysis, and Phenotyping Toward Understanding Responsive, Reparative, Remodelling, and Recombinant Events (iCAPTURE) Centre, University of British Columbia, Vancouver, British Columbia, Canada
    • ,
  • Yohan Bossé, PhD

      Affiliations

    • Institut universitaire de cardiologie et de pneumologie de Québec, Quebec, Canada
    • Department of Medicine, Laval University Hospital Research Center, Quebec City, Quebec, Canada
    • ,
  • Anita L. Kozyrskyj, PhD

      Affiliations

    • Department of Pediatrics, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada
    • Department of Pediatrics and Child Health, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
    • ,
  • Alan James, MD

      Affiliations

    • West Australian Sleep Disorders Research Institute, Sir Charles Gairdner Hospital, Perth, Australia
    • ,
  • Catherine Laprise, PhD

      Affiliations

    • Département des Sciences Fondamentales, Université du Québec à Chicoutimi, Quebec, Canada
    • Université de Montréal Community Genomic Medicine Center, Chicoutimi Hospital, Canada
    • ,
  • Denise Daley, PhD

      Affiliations

    • James Hogg Imaging, Cell Analysis, and Phenotyping Toward Understanding Responsive, Reparative, Remodelling, and Recombinant Events (iCAPTURE) Centre, University of British Columbia, Vancouver, British Columbia, Canada
    • Division of Respiratory Medicine, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada
    • Corresponding Author InformationReprint requests: Denise Daley, PhD, UBC James Hogg iCAPTURE Centre, 1081 Burrard Street, Vancouver, BC, Canada V6Z 1Y6.

Received 10 December 2008 ,Revised 6 April 2009 ,Accepted 8 April 2009.

  • Image Result

    Pairwise linkage disequilibria of TSLP SNPs evaluated by the r2 value. The r2 values are calculated pairwise, and the r2 value appears in the corresponding box. Upper left, CAPPS; lower left, SAGE; up

    Pairwise linkage disequilibria of TSLP SNPs evaluated by the r2 value. The r2 values are calculated pairwise, and the r2 value appears in the corresponding box. Upper left, CAPPS; lower left, SAGE; upper right, SLSJ; lower right, Busselton study. Only 1 common haplotype was identified in each population, and a triangle identifies the block boundary.

  • Image Result
    The combined results of the associations of SNPs in the TSLP gene with 4 asthma-related phenotypes. Genes are ordered on the x-axis by chromosome and position. The legend for the phenotypes is in the

    The combined results of the associations of SNPs in the TSLP gene with 4 asthma-related phenotypes. Genes are ordered on the x-axis by chromosome and position. The legend for the phenotypes is in the top right corner. Corrected P values are on the y-axis. SNPs with corrected P values <.05 are labeled with gene name; ∗the SNP has been previously reported in the literature; [ ] indicates coding nonsynonymous SNP. EDN1: Endothelin 1; IL13: Interleukin 13; IL18: Interleukin 18; IFNGR2: Interferon gamma receptor 2; NOD2: Nucleotide-binding oligomerization domain containing 2; NPSR1: Neuropeptide S receptor 1; TLR9: Toll-like receptor 9; TLR10: Toll-like receptor 10; VDR: Vitamin D (1,25- dihydroxyvitamin D3) receptor; STAT6: Signal transducer and activator of transcription 6, interleukin-4 induced; TBXA2R: Thromboxane A2 receptor.

 Supported by AllerGen, a National Centre of Excellence Network (Canada); the Canadian Institutes of Health Research; the Institutes of Gender and Health; British Columbia Lung Association; Génome Québec; and the Respiratory Health Network of the Fonds de la Recherche en Santé du Québec. The 1994 Busselton follow-up study was funded by Healthway, Australia. J.-Q.H. is the recipient of a Michael Smith Foundation for Health Research Doctoral Award and an Izaak Walton Killam Memorial Scholarship Award. D.K. is a Canada Research Chair, a recipient of a Michael Smith Foundation Scholarship and the William Thurlbeck Distinguished Research Award. A.J. is a recipient of a National Health and Medical Research Council of Australia Practitioner Fellowship. Y.B. and D.D. were recipients of fellowship awards (Canadian Institutes of Health Research), and A.L.K. is a recipient of a New Investigator Award (Canadian Institutes of Health Research). D.D. is the recipient of a Michael Smith Foundation Career Scholar Award. D.D., C.L., and A.S. hold Canadian Research Chair appointments. This work was also supported by the National Health and Medical Research Council of Australia (303145, 458513), the Child Health Research Foundation of Western Australia, and the Asthma Foundation of Western Australia.

 Disclosure of potential conflict of interest: D. Daley receives grant support from AllerGen and the Canadian Institutes of Health Research. T. S. Hallstrand is on the speakers' bureau for Merck and Schering-Plough, is a consultant for Merck, and receives grant support from the National Institutes of Health, the American Lung Foundation, the Firland Foundation, and Novartis. D. Knight receives grant support from Centocor and Sepracor. A. Sandford receives grant support from the British Columbia Lung Association and the Canadian Institutes of Health Research. Y. Bossé receives grant support from the Québec Institute of Cardiology, Fonds de la Recherche en Santé du Québec, the Heart and Stroke Foundation, and the Respiratory Health Network of the Fonds de la Recherche en Santé du Québec. The rest of the authors have declared that they have no conflict of interest.

PII: S0091-6749(09)00643-5

doi: 10.1016/j.jaci.2009.04.018

The Journal of Allergy and Clinical Immunology
Volume 124, Issue 2 , Pages 222-229 , August 2009

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