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Volume 124, Issue 2 , Pages 222-229, August 2009

A thymic stromal lymphopoietin gene variant is associated with asthma and airway hyperresponsiveness

Jian-Qing He, MD
- James Hogg Imaging, Cell Analysis, and Phenotyping Toward Understanding Responsive, Reparative, Remodelling, and Recombinant Events (iCAPTURE) Centre, University of British Columbia, Vancouver, British Columbia, Canada
Teal S. Hallstrand, MD, MPH
- Department of Medicine, Division of Pulmonary and Critical Care, University of Washington, Seattle, Wash
Darryl Knight, PhD
- James Hogg Imaging, Cell Analysis, and Phenotyping Toward Understanding Responsive, Reparative, Remodelling, and Recombinant Events (iCAPTURE) Centre, University of British Columbia, Vancouver, British Columbia, Canada
- Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, British Columbia, Canada
Moira Chan-Yeung, MD
- Occupational and Environmental Lung Disease Unit, University of British Columbia, Vancouver, British Columbia, Canada
Andrew Sandford, PhD
- James Hogg Imaging, Cell Analysis, and Phenotyping Toward Understanding Responsive, Reparative, Remodelling, and Recombinant Events (iCAPTURE) Centre, University of British Columbia, Vancouver, British Columbia, Canada
- Division of Respiratory Medicine, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada
Ben Tripp, BSs
- James Hogg Imaging, Cell Analysis, and Phenotyping Toward Understanding Responsive, Reparative, Remodelling, and Recombinant Events (iCAPTURE) Centre, University of British Columbia, Vancouver, British Columbia, Canada
David Zamar, MSc
- James Hogg Imaging, Cell Analysis, and Phenotyping Toward Understanding Responsive, Reparative, Remodelling, and Recombinant Events (iCAPTURE) Centre, University of British Columbia, Vancouver, British Columbia, Canada
Yohan Bossé, PhD
- Institut universitaire de cardiologie et de pneumologie de Québec, Quebec, Canada
- Department of Medicine, Laval University Hospital Research Center, Quebec City, Quebec, Canada
Anita L. Kozyrskyj, PhD
- Department of Pediatrics, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada
- Department of Pediatrics and Child Health, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
Alan James, MD
- West Australian Sleep Disorders Research Institute, Sir Charles Gairdner Hospital, Perth, Australia
Catherine Laprise, PhD
- Département des Sciences Fondamentales, Université du Québec à Chicoutimi, Quebec, Canada
- Université de Montréal Community Genomic Medicine Center, Chicoutimi Hospital, Canada
Denise Daley, PhD
- James Hogg Imaging, Cell Analysis, and Phenotyping Toward Understanding Responsive, Reparative, Remodelling, and Recombinant Events (iCAPTURE) Centre, University of British Columbia, Vancouver, British Columbia, Canada
- Division of Respiratory Medicine, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada
- Reprint requests: Denise Daley, PhD, UBC James Hogg iCAPTURE Centre, 1081 Burrard Street, Vancouver, BC, Canada V6Z 1Y6.

Received 10 December 2008; received in revised form 6 April 2009; accepted 8 April 2009. published online 22 June 2009.

Full Text Available

Supported by AllerGen, a National Centre of Excellence Network (Canada); the Canadian Institutes of Health Research; the Institutes of Gender and Health; British Columbia Lung Association; Génome Québec; and the Respiratory Health Network of the Fonds de la Recherche en Santé du Québec. The 1994 Busselton follow-up study was funded by Healthway, Australia. J.-Q.H. is the recipient of a Michael Smith Foundation for Health Research Doctoral Award and an Izaak Walton Killam Memorial Scholarship Award. D.K. is a Canada Research Chair, a recipient of a Michael Smith Foundation Scholarship and the William Thurlbeck Distinguished Research Award. A.J. is a recipient of a National Health and Medical Research Council of Australia Practitioner Fellowship. Y.B. and D.D. were recipients of fellowship awards (Canadian Institutes of Health Research), and A.L.K. is a recipient of a New Investigator Award (Canadian Institutes of Health Research). D.D. is the recipient of a Michael Smith Foundation Career Scholar Award. D.D., C.L., and A.S. hold Canadian Research Chair appointments. This work was also supported by the National Health and Medical Research Council of Australia (303145, 458513), the Child Health Research Foundation of Western Australia, and the Asthma Foundation of Western Australia.

Disclosure of potential conflict of interest: D. Daley receives grant support from AllerGen and the Canadian Institutes of Health Research. T. S. Hallstrand is on the speakers' bureau for Merck and Schering-Plough, is a consultant for Merck, and receives grant support from the National Institutes of Health, the American Lung Foundation, the Firland Foundation, and Novartis. D. Knight receives grant support from Centocor and Sepracor. A. Sandford receives grant support from the British Columbia Lung Association and the Canadian Institutes of Health Research. Y. Bossé receives grant support from the Québec Institute of Cardiology, Fonds de la Recherche en Santé du Québec, the Heart and Stroke Foundation, and the Respiratory Health Network of the Fonds de la Recherche en Santé du Québec. The rest of the authors have declared that they have no conflict of interest.

PII: S0091-6749(09)00643-5

doi:10.1016/j.jaci.2009.04.018

« Previous Next »The Journal of Allergy and Clinical Immunology
Volume 124, Issue 2 , Pages 222-229, August 2009