The Journal of Allergy and Clinical Immunology
Volume 124, Issue 1 , Pages 45-51.e4 , July 2009

Airway remodeling in subjects with severe asthma with or without chronic persistent airflow obstruction

  • Marta Kaminska, MD

      Affiliations

    • Meakins-Christie Laboratories, Montreal, Quebec, Canada
    • ,
  • Susan Foley, MD

      Affiliations

    • Meakins-Christie Laboratories, Montreal, Quebec, Canada
    • ,
  • Karim Maghni, DSc, PhD

      Affiliations

    • Centre de Recherche de l'Hopital du Sacré-Coeur de Montréal, Montreal, Quebec, Canada
    • ,
  • Claudine Storness-Bliss, BSc

      Affiliations

    • Department of Radiology and the James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, Vancouver General Hospital, Vancouver, British Columbia, Canada
    • ,
  • Harvey Coxson, PhD

      Affiliations

    • Department of Radiology and the James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, Vancouver General Hospital, Vancouver, British Columbia, Canada
    • ,
  • Heberto Ghezzo, PhD

      Affiliations

    • Meakins-Christie Laboratories, Montreal, Quebec, Canada
    • ,
  • Catherine Lemière, MD, MSc

      Affiliations

    • Centre de Recherche de l'Hopital du Sacré-Coeur de Montréal, Montreal, Quebec, Canada
    • ,
  • Ronald Olivenstein, MD

      Affiliations

    • Meakins-Christie Laboratories, Montreal, Quebec, Canada
    • ,
  • Pierre Ernst, MD

      Affiliations

    • Meakins-Christie Laboratories, Montreal, Quebec, Canada
    • ,
  • Qutayba Hamid, MD, PhD

      Affiliations

    • Meakins-Christie Laboratories, Montreal, Quebec, Canada
    • ,
  • James Martin, MD, DSc

      Affiliations

    • Meakins-Christie Laboratories, Montreal, Quebec, Canada
    • Corresponding Author InformationReprint requests: James Martin, MD, DSc, Meakins Christie Laboratories, 3626 St Urbain, Montreal, Quebec, Canada, H2X 2P2.

Received 31 July 2008 ,Revised 4 March 2009 ,Accepted 16 March 2009.

  • Image Result

    ASM in endobronchial biopsy specimens. Smooth muscle bundles (shown in brown) are larger in a subject with chronic persistent obstruction (B) than in a subject with intermittent obstruction (A). C, Is

    ASM in endobronchial biopsy specimens. Smooth muscle bundles (shown in brown) are larger in a subject with chronic persistent obstruction (B) than in a subject with intermittent obstruction (A). C, Isotype control (α-smooth muscle actin immunoperoxidase staining).

  • Image Result
    Correlation between SMA (percentage of total biopsy area) and FEV1 (percent predicted) in subjects with severe asthma. Solid triangles, Subjects with chronic persistent obstruction; open triangles, su

    Correlation between SMA (percentage of total biopsy area) and FEV1 (percent predicted) in subjects with severe asthma. Solid triangles, Subjects with chronic persistent obstruction; open triangles, subjects with intermittent obstruction.

  • Image Result
    Correlation between Pi10 (a measure of airway wall thickness on HRCT, see the Methods section for details) and RBM thickness (A) and SMA % (B) for 13 subjects who underwent HRCT and a biopsy and betwe

    Correlation between Pi10 (a measure of airway wall thickness on HRCT, see the Methods section for details) and RBM thickness (A) and SMA % (B) for 13 subjects who underwent HRCT and a biopsy and between Pi10 and FEV1 percent predicted (from the study visit closest to HRCT; n = 21; C).

  • Image Result
    Correlation between SMA% on bronchial biopsy and concentrated sputum supernatant cytokines measured with the Bio-Plex assay.

    Correlation between SMA% on bronchial biopsy and concentrated sputum supernatant cytokines measured with the Bio-Plex assay.

 Supported by the Richard and Edith Strauss Canada Foundation, Canadian Institutes of Health Research.

 Disclosure of potential conflict of interest: H. Coxson has served as a consultant/advisor board member for GlaxoSmithKline and has received research support fro GlaxoSmithKline, Spiration, and Wyeth. C. Lemière has received research support from the National Institute for Occupational Safety and Health and the Institut de Recherche Robert-Sauvé en Santé et Sécurité du Travail and has served as an advisor to GlaxoSmithKline, AstraZeneca, and Novartis. P. Ernst has received speaker's fees from or served on an advisory board for AstraZeneca, Boehringer Ingelheim, GlaxoSmithKline, Merck, Novartis, and Nycomed. Q. Hamid has received research support from the McGill University Health Center Strauss Foundation. The rest of the authors have declared that they have no conflict of interest.

PII: S0091-6749(09)00637-X

doi: 10.1016/j.jaci.2009.03.049

The Journal of Allergy and Clinical Immunology
Volume 124, Issue 1 , Pages 45-51.e4 , July 2009

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