The Journal of Allergy and Clinical Immunology
Volume 123, Issue 6, Supplement , Pages S365-S383 , June 2009

Work Group report: Oral food challenge testing

  • Anna Nowak-Węgrzyn, MD

      Affiliations

    • Jaffe Food Allergy Institute, Mount Sinai School of Medicine, New York, NY
    • ,
  • Amal H. Assa'ad, MD

      Affiliations

    • Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio
    • Corresponding Author InformationReprint requests: Amal Assa'ad, MD, Professor of Pediatrics, Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, and Past-Chair, Adverse Reactions to Foods Committee, 3333 Burnet Ave, Cincinnati, OH 45229.
    • Authors listed alphabetically.
    • ,
  • Sami L. Bahna, MD, DrPH

      Affiliations

    • Louisiana State University Health Sciences Center, Shreveport, La
    • Authors listed alphabetically.
    • ,
  • S. Allan Bock, MD

      Affiliations

    • National Jewish Health and University of Colorado Health Sciences Center, Denver, Colo
    • Authors listed alphabetically.
    • ,
  • Scott H. Sicherer, MD

      Affiliations

    • Jaffe Food Allergy Institute, Mount Sinai School of Medicine, New York, NY
    • Authors listed alphabetically.
    • ,
  • Suzanne S. Teuber, MD

      Affiliations

    • University of California, Davis, School of Medicine, Davis, Calif
    • Authors listed alphabetically.
    • ,
  • Adverse Reactions to Food Committee of the American Academy of Allergy, Asthma & Immunology

Received 11 August 2008 ,Revised 11 March 2009 ,Accepted 23 March 2009.

  • Image Result

    Decision process regarding selection of open vs blind OFCs. ∗Blinded portions of the OFC must always be followed by an open feeding with an age-appropriate serving of food in its natural form or the l

    Decision process regarding selection of open vs blind OFCs. ∗Blinded portions of the OFC must always be followed by an open feeding with an age-appropriate serving of food in its natural form or the least cooked/baked/processed form of food that will be incorporated into the patient's diet at home.

  • Image Result
    Template developed on the basis of Bock SA, Sampson HA, Atkins FM, et al. Double-blind, placebo-controlled food challenge (DBPCFC) as an office procedure: a manual. J Allergy Clin Immunol 1988;82:986-

    Template developed on the basis of Bock SA, Sampson HA, Atkins FM, et al. Double-blind, placebo-controlled food challenge (DBPCFC) as an office procedure: a manual. J Allergy Clin Immunol 1988;82:986-97;3 and forms for the National Institutes of Health–sponsored Consortium of Food Allergy Research (U19 AI066738). AD, atopic dermatitis; AR, allergic rhinitis; BP, blood pressure; FVC, forced vital capacity; HEENT, head, eyes, ears, nose, and throat; IM, intramuscular injection; IV, intravenous injection; sol, solution; URI, upper respiratory infection. For complete guidelines for treatment of anaphylaxis, see Lieberman et al.123

  • Image Result
    Template developed on the basis of Bock SA, Sampson HA, Atkins FM, et al. Double-blind, placebo-controlled food challenge (DBPCFC) as an office procedure: a manual. J Allergy Clin Immunol 1988;82:986-

    Template developed on the basis of Bock SA, Sampson HA, Atkins FM, et al. Double-blind, placebo-controlled food challenge (DBPCFC) as an office procedure: a manual. J Allergy Clin Immunol 1988;82:986-973; and forms for the National Institutes of Health–sponsored Consortium of Food Allergy Research (U19 AI066738). ED, Emergency department; GI, gastrointestinal; SBPCFC, single-blind, placebo-controlled food challenge.

  • Image Result
    Example of an OFC symptom score sheet. Modified from Bock SA, Sampson HA, Atkins FM, et al. Double-blind, placebo-controlled food challenge (DBPCFC) as an office procedure: a manual. J Allergy Clin Im

    Example of an OFC symptom score sheet. Modified from Bock SA, Sampson HA, Atkins FM, et al. Double-blind, placebo-controlled food challenge (DBPCFC) as an office procedure: a manual. J Allergy Clin Immunol 1988;82:986-973; and forms for the National Institutes of Health–sponsored Consortium of Food Allergy Research (U19 AI066738).

 Supported by the Food Allergy Initiative. The Food Allergy Initiative is a nonprofit corporation dedicated to finding a cure for food allergies by funding food allergy research; it does not conduct scientific research or render medical advice. The opinion in the manuscript reflects that of the authors and not that of the Food Allergy Initiative, and Food Allergy Initiative is not responsible or liable for the information set forth in the manuscript or for any damages that may result from its use.

 Disclosure of potential conflict of interest: A. Assa'ad has received research support from GlaxoSmithKline. A. Nowak-Węgrzyn has received research support from the National Institutes of Health. S. L. Bahna has received research support from Genentech/Novartis and CSL Behring. S. H. Sicherer has received research support from the National Institutes of Health/National Institute of Allergy and Infectious Diseases and is a consultant for the Food Allergy Initiative and a medical advisor for the Food Allergy and Anaphylaxis Network. The rest of the authors have declared that they have no conflict of interest.

PII: S0091-6749(09)00562-4

doi: 10.1016/j.jaci.2009.03.042

The Journal of Allergy and Clinical Immunology
Volume 123, Issue 6, Supplement , Pages S365-S383 , June 2009

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