The Journal of Allergy and Clinical Immunology
Volume 124, Issue 2 , Pages 286-291.e6 , August 2009

Safety of a peanut oral immunotherapy protocol in children with peanut allergy

  • Alison M. Hofmann, MD

      Affiliations

    • Division of Allergy and Immunology, Department of Pediatrics, Duke University Medical Center, Durham, NC
    • ,
  • Amy M. Scurlock, MD

      Affiliations

    • Division of Allergy and Immunology, Department of Pediatrics, University of Arkansas, Little Rock, Ark
    • ,
  • Stacie M. Jones, MD

      Affiliations

    • Division of Allergy and Immunology, Department of Pediatrics, University of Arkansas, Little Rock, Ark
    • ,
  • Kricia P. Palmer, MD

      Affiliations

    • Division of Allergy and Immunology, Department of Pediatrics, University of Arkansas, Little Rock, Ark
    • ,
  • Yuliya Lokhnygina, PhD

      Affiliations

    • Department of Biostatistics and Bioinformatics, Duke University, Durham, NC
    • ,
  • Pamela H. Steele, CPNP

      Affiliations

    • Division of Allergy and Immunology, Department of Pediatrics, Duke University Medical Center, Durham, NC
    • ,
  • Janet Kamilaris, RN

      Affiliations

    • Division of Allergy and Immunology, Department of Pediatrics, Duke University Medical Center, Durham, NC
    • ,
  • A. Wesley Burks, MD

      Affiliations

    • Division of Allergy and Immunology, Department of Pediatrics, Duke University Medical Center, Durham, NC
    • Corresponding Author InformationReprint requests: Wesley Burks, MD, Division of Allergy and Immunology, Duke University Medical Center, Box 2644, Durham, NC 27710.

Received 14 October 2008 ,Revised 30 March 2009 ,Accepted 31 March 2009.

References 

  1. Sicherer S, Munoz-Furlong A, Sampson HA. Prevalence of peanut and tree nut allergy in the United States determined by means of a random digit dial telephone survey: a 5-year follow-up study. J Allergy Clin Immunol. 2003;112:1203–1207
  2. Sicherer SH, Burks AW, Sampson HA. Clinical features of acute allergic reactions to peanut and tree nuts in children. Pediatrics. 1998;102:e6
  3. Fleischer DM. The natural history of peanut and tree nut allergy. Curr Allergy Asthma Rep. 2007;7:175–181
  4. Fleischer DM, Conover-Walker MK, Christie L, Burks AW, Wood RA. Peanut allergy: recurrence and its management. J Allergy Clin Immunol. 2004;114:1195–1201
  5. Nelson HS, Lahr J, Rule R, Bock A, Leung D. Treatment of anaphylactic sensitivity to peanuts by immunotherapy with injections of aqueous peanut extract. J Allergy Clin Immunol. 1997;99:744–751
  6. King N, Helm R, Stanley JS, Vieths S, Luttkopf D, Hatahet L, et al. Allergenic characteristics of a modified peanut allergen. Mol Nutr Food Res. 2005;49:963–967
  7. Leung DY, Sampson HA, Yunginger JW, Burks AW, Schneider LC, Wortel CH, et al. Avon Longitudinal Study of Parents and Children Study Team Effect of anti-IgE therapy in patients with peanut allergy. N Engl J Med. 2003;348:986–993
  8. Niggeman B, Staden U, Rolinck-Werninghaus C, Beyer K. Specific oral tolerance induction in food allergy. Allergy. 2006;61:808–811
  9. Meglio P, Bartone E, Plantamura M, Arabito E, Giampietro PG. A protocol for oral desensitization in children with IgE-mediated cow's milk allergy. Allergy. 2004;59:980–987
  10. Patriarca G, Nucera E, Pollastrini E, Roncallo C, De Pasquale T, Lombardo C, et al. Oral specific desensitization in food-allergic children. Dig Dis Sci. 2007;52:1662–1672
  11. Buchanan AD, Green TD, Jones SM, Scurlock AM, Christie L, Althage KA, et al. Egg oral immunotherapy in nonanaphylactic children with egg allergy. J Allergy Clin Immunol. 2007;119:199–205
  12. Longo G, Barbi E, Berti I, Meneghetti R, Pittalis A, Ronfani L, et al. Specific oral tolerance induction in children with very severe cow's milk-induced reactions. J Allergy Clin Immunol. 2008;121:343–347
  13. International Tree Nut Council Nutrition Research & Education Foundation. Nutrients in 1 ounce of tree nuts and peanuts. Available at:http://www.nuthealth.org/nutrition/nutrient1oz.html. Accessed September 2008.
  14. Sicherer SH, Sampson HA. Peanut allergy: emerging concepts and approaches for an apparent epidemic. J Allergy Clin Immunol. 2007;120:491–503
  15. Mansfield L. Successful oral desensitization for systemic peanut allergy. Ann Allergy Asthma Immunol. 2006;97:266–267
  16. Patriarca G, Nucera E, Pollastrini E, De Pasquale T, Lombardo C, Buonomo A, et al. Oral rush desensitization in peanut allergy: a case report. Dig Dis Sci. 2006;51:471–473
  17. Allen CW, Campbell DE, Kemp AS. Egg allergy: are all childhood food allergies the same?. J Pediatr Child Health. 2007;43:214–218
  18. Bock SA, Muñoz-Furlong A, Sampson HA. Further fatalities caused by anaphylactic reactions to food, 2001-2006. J Allergy Clin Immunol. 2007;119:1016–1018
  19. Sampson HA, Mendelson LM, Rosen JP. Fatal and near-fatal anaphylactic reactions to food in children and adolescents. N Engl J Med. 1992;327:380–384
  20. Yunginger JW, Sweeney KG, Sturner WQ. Fatal food-induced anaphylaxis. JAMA. 1988;260:1450–1452
  21. Jones SM, Pons L, Roberts JL, Scurlock AM, Perry TT, Kulis M, et al. Clinical Efficacy and Immune Regulation With Peanut Oral Immunotherapy. J Allergy Clin Immunol. 2009;124:292–300

 Supported by the Food Allergy and Anaphylaxis Network, the Gerber Foundation, the Food Allergy Project, and the Dorothy and Frank Robins Family Foundation. The project described was supported by grant no. 1 UL1 RR024128-01 from the National Center for Research Resources (NCRR), a component of the National Institutes of Health (NIH) and NIH Roadmap for Medical Research, and its contents are solely the responsibility of the authors and do not necessarily represent the official view of NCRR or NIH.

 Disclosure of potential conflict of interest: A. M. Hofmann has received research support from the Pediatric Scientist Development Program. A. M. Scurlock has received research support from Genocea Biosciences and NIH. S. M. Jones has received research support from the National Peanut Board, the National Institutes of Health, the National Institute of Allergy and Infectious Diseases, and Dyax Corp and is on the Medical Advisory Board for the Food Allergy and Anaphylaxis Network. A. W. Burks is a consultant for ActoGeniX NV, Novartis, McNeil Nutritionals, and Mead Johnson; is a minority stockholder with Allertein and MastCell, Inc; is on the Advisory Board of Dannon Co Probiotics; is on the speakers' bureau for EpiPen/Dey, LP; is on the Data Monitoring Committee for Genentech; is on the Expert Panel for Nutricia; has received research support from the National Institutes of Health, the Food Allergy and Anaphylaxis Network, Gerber, and Mead Johnson; has provided legal consultation regarding food allergy; is on the Medical Board of Directors for the Food Allergy and Anaphylaxis Network; is a Dermatological Allergy Committee member of the American College of Allergy, Asthma & Immunology; is a study section member at the National Institutes of Health Hypersensitivity, Autoimmune, Immune-mediated Diseases; and is on the Journal of Allergy and Clinical Immunology reviewer board. The rest of the authors have declared that they have no conflict of interest.

PII: S0091-6749(09)00556-9

doi: 10.1016/j.jaci.2009.03.045

The Journal of Allergy and Clinical Immunology
Volume 124, Issue 2 , Pages 286-291.e6 , August 2009

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