IL-2– and CD25-dependent immunoregulatory mechanisms in the homeostasis of T-cell subsets

IL-2 plays a pivotal role in regulating the adaptive immune system by controlling the survival and proliferation of regulatory T (Treg) cells, which are required for the maintenance of immune tolerance. Moreover, IL-2 is implicated in the differentiation and homeostasis of effector T-cell subsets, including T_H1, T_H2, T_H17, and memory CD8⁺ T cells. The IL-2 receptor is composed of 3 distinct subunits, namely the α (CD25), β (CD122), and γ (γc) chains. Of crucial importance for the delivery of IL-2 signals to Treg cells is the expression of CD25, which, along with CD122 and γc, confers high affinity binding to IL-2. Notably, recent findings suggest a novel role for CD25, whereby CD25 molecules on Treg cells and possibly other cells are capable of influencing T-cell homeostasis by means of IL-2 deprivation. This review explores these findings and integrates them into our current understanding of T-cell homeostasis.

Key words: IL-2, CD25, T-cell homeostasis, CD8 T cell, regulatory T cell, T_H1, T_H2, T_H17, cytokine deprivation

Abbreviations used: DC, Dendritic cell, FoxP3, Forkhead box P3, IL-2R, IL-2 receptor, NK, Natural killer, TCR, T-cell receptor, Treg, Regulatory T cell