The Journal of Allergy and Clinical Immunology
Volume 123, Issue 3 , Pages 569-574, March 2009

Advances in mechanisms of asthma, allergy, and immunology in 2008

  • Joshua A. Boyce, MD

      Affiliations

    • Department of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, and the Department of Pediatrics, Harvard Medical School, Boston, Mass
    • ,
  • David Broide, MB, ChB

      Affiliations

    • Department of Medicine, Division of Rheumatology, Allergy and Immunology, University of California San Diego, La Jolla, Calif
    • ,
  • Kenji Matsumoto, MD, PhD

      Affiliations

    • Department of Allergy and Immunology, National Research Institute for Child Health and Development, Tokyo, Japan
    • ,
  • Bruce S. Bochner, MD

      Affiliations

    • Department of Medicine, Division of Allergy and Clinical Immunology, Johns Hopkins University School of Medicine, Baltimore, Md
    • Corresponding Author InformationReprint requests: Bruce S. Bochner, MD, Johns Hopkins Asthma and Center, 5501 Hopkins Bayview Circle, Room 2B71, Baltimore, MD, 21224.

Received 6 January 2009; accepted 7 January 2009.

This review summarizes selected articles appearing in 2008 in the Journal. Articles chosen include those improving our understanding of mechanisms of allergic diseases by focusing on human basophil, mast cell, and eosinophil biology; IgE and its high-affinity receptor on various cells; novel properties of omalizumab; airways remodeling; and genetics. Articles from other journals have been included to supplement the topics presented.

Abbreviations used: ADAM, A disintegrin and metalloprotease, AHR, Airway hyperresponsiveness, FIP1L1-PDGFRA, Fip1-like1–platelet-derived growth factor receptor α-chain, MMCP, Mouse mast cell protease, PI-3K, Phospatidylinostol-3-phosphate kinase, Siglec, Sialic acid–binding immunoglobulin-like lectin, Syk, Spleen-type tyrosine kinase, Treg, Regulatory T, VEGF, Vascular endothelial growth factor

 

 Disclosure of potential conflict of interest: J. A. Boyce is a speaker for Merck and has received research support from the National Institutes of Health. B. S. Bochner has consulted for Sanofi-Aventis, Amgen, and Therakos; has received speaker honoraria from Merck; and has received research support from Enobia and the National Institutes of Health. D. Broide has received research support from the National Institutes of Health. K. Matsumoto has declared that he has no conflicts of interest.

PII: S0091-6749(09)00159-6

doi:10.1016/j.jaci.2009.01.041

The Journal of Allergy and Clinical Immunology
Volume 123, Issue 3 , Pages 569-574, March 2009

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