The Journal of Allergy and Clinical Immunology
Volume 123, Issue 5 , Pages 1163-1169.e4 , May 2009

Association of obesity with IgE levels and allergy symptoms in children and adolescents: Results from the National Health and Nutrition Examination Survey 2005-2006

  • Cynthia M. Visness, PhD

      Affiliations

    • Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC
    • Rho Federal Systems Division, Inc, Chapel Hill, NC
    • Corresponding Author InformationReprint requests: Cynthia M. Visness, PhD, Rho Federal Systems Division, Inc, 6330 Quadrangle Dr, Suite 500, Chapel Hill, NC 27517.
    • ,
  • Stephanie J. London, MD, DrPH

      Affiliations

    • Division of Intramural Research, National Institute of Environmental Health Sciences, Research Triangle Park, NC
    • ,
  • Julie L. Daniels, PhD

      Affiliations

    • Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC
    • ,
  • Jay S. Kaufman, PhD

      Affiliations

    • Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC
    • ,
  • Karin B. Yeatts, PhD

      Affiliations

    • Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC
    • ,
  • Anna-Maria Siega-Riz, PhD

      Affiliations

    • Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC
    • ,
  • Andrew H. Liu, MD

      Affiliations

    • National Jewish Health and University of Colorado Health Science Center, Denver, Colo
    • ,
  • Agustin Calatroni, MA, MS

      Affiliations

    • Rho Federal Systems Division, Inc, Chapel Hill, NC
    • ,
  • Darryl C. Zeldin, MD

      Affiliations

    • Division of Intramural Research, National Institute of Environmental Health Sciences, Research Triangle Park, NC

Received 3 December 2008 ,Accepted 19 December 2008.

References 

  1. Ogden CL, Carroll MD, Curtin LR, McDowell MA, Tabak CJ, Flegal KM. Prevalence of overweight and obesity in the United States, 1999-2004. JAMA. 2006;295:1549–1555
  2. Arbes SJ, Gergen PJ, Elliott L, Zeldin DC. Prevalences of positive skin test responses to 10 common allergens in the US population: results from the third National Health and Nutrition Examination Survey. J Allergy Clin Immunol. 2005;116:377–383
  3. Law M, Morris JK, Wald N, Luczynska C, Burney P. Changes in atopy over a quarter of a century, based on cross sectional data at three time periods. BMJ. 2005;330:1187–1188
  4. Schernhammer ES, Vutuc C, Waldhor T, Haidinger G. Time trends of the prevalence of asthma and allergic disease in Austrian children. Pediatr Allergy Immunol. 2008;19:125–131
  5. von Mutius E. The rising trends in asthma and allergic disease. Clin Exp Allergy. 1998;28(suppl 5):S45–S51
  6. Huang SL, Shiao G, Chou P. Association between body mass index and allergy in teenage girls in Taiwan. Clin Exp Allergy. 1999;29:323–329
  7. Schachter LM, Peat JK, Salome CM. Asthma and atopy in overweight children. Thorax. 2003;58:1031–1035
  8. Xu B, Jarvelin MR, Pekkanen J. Body build and atopy. J Allergy Clin Immunol. 2000;105:393–394
  9. Jarvis D, Chinn S, Potts J, Burney P. Association of body mass index with respiratory symptoms and atopy: results from the European Community Respiratory Health Survey. Clin Exp Allergy. 2002;32:831–837
  10. Tantisira KG, Litonjua AA, Weiss ST, Fuhlbrigge AL. Association of body mass with pulmonary function in the Childhood Asthma Management Program (CAMP). Thorax. 2003;58:1036–1041
  11. Chen Y, Dales R, Jiang Y. The association between obesity and asthma is stronger in nonallergic than allergic adults. Chest. 2006;130:890–895
  12. von Mutius E, Schwartz J, Neas LM, Dockery D, Weiss ST. Relation of body mass index to asthma and atopy in children: the National Health and Nutrition Examination Study III. Thorax. 2001;56:835–838
  13. Butland BK, Strachan DP, Rudnicka AR. C-reactive protein, obesity, atopy and asthma symptoms in middle-aged British adults. Eur Respir J. 2008;32:77–84
  14. National Center for Health Statistics. Let's improve Our health: National Health and Nutrition Examination Survey, 2007-2008, Overview. Hyattsville (MD): Centers for Disease Control and Prevention; 2007;
  15. Centers for Disease Control . Clinical growth charts. Hyattsville (MD): National Center for Health Statistics; 2007;
  16. Krebs NF, Himes JH, Jacobson D, Nicklas TA, Guilday P, Styne D. Assessment of child and adolescent overweight and obesity. Pediatrics. 2007;120(suppl 4):S193–S228
  17. US Census Bureau . How the census bureau measures poverty. Washington (DC): US Census Bureau; 2007;
  18. Braback L, Hjern A, Rasmussen F. Body mass index, asthma and allergic rhinoconjunctivitis in Swedish conscripts-a national cohort study over three decades. Respir Med. 2005;99:1010–1014
  19. R Development Core Team. R: a language and environment for statistical computing. Vienna: Foundation for Statistical Computing; 2008;
  20. Burkhauser RV, Cawley J. Beyond BMI: the value of more accurate measures of fatness and obesity in social science research. J Health Econ. 2008;27:519–529
  21. Mei Z, Grummer-Strawn LM, Pietrobelli A, Goulding A, Goran MI, Dietz WH. Validity of body mass index compared with other body-composition screening indexes for the assessment of body fatness in children and adolescents. Am J Clin Nutr. 2002;75:978–985
  22. Rothman KJ, Greenland S. Modern epidemiology. 2nd ed.. Philadelphia: Lippincott, Williams and Wilkins; 1998;
  23. Kalliomaki M, Collado MC, Salminen S, Isolauri E. Early differences in fecal microbiota composition in children may predict overweight. Am J Clin Nutr. 2008;87:534–538
  24. Ludwig DS, Peterson KE, Gortmaker SL. Relation between consumption of sugar-sweetened drinks and childhood obesity: a prospective, observational analysis. Lancet. 2001;357:505–508
  25. Welsh JA, Cogswell ME, Rogers S, Rockett H, Mei Z, Grummer-Strawn LM. Overweight among low-income preschool children associated with the consumption of sweet drinks: Missouri, 1999-2002. Pediatrics. 2005;115:e223–e229

 Supported in part by the Intramural Research Program of the National Institutes of Health, National Institute of Environmental Health Sciences (Z01 ES025041-10), and by the National Institute of Allergy and Infectious Diseases, National Institutes of Health (NO1-AI-25482).

 Disclosure of potential conflict of interest: J. S. Kaufman receives grant support from the Robert Wood Johnson Foundation and the National Institutes of Health. A.-M. Siega-Riz receives grant support from the National Institute of Diabetes and Digestive and Kidney Diseases, the Centers for Disease Control and Prevention, the National Institutes of Health, and the National Heart, Lung, and Blood Institute; is on the advisory board for the American Diabetes Association; and is a scientific advisor for Nestle-Gerber products and Shoulder to Shoulder. A. H. Liu is on the review board for the National Institutes of Health/National Institute of Environmental Health Sciences. The rest of the authors have declared that they have no conflict of interest.

PII: S0091-6749(09)00115-8

doi: 10.1016/j.jaci.2008.12.1126

The Journal of Allergy and Clinical Immunology
Volume 123, Issue 5 , Pages 1163-1169.e4 , May 2009

Article Tools

* Image Usage & Resolution